{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:18:53Z","timestamp":1787750333208,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract:<\/jats:title>\n \n OBJECTIVES:<\/jats:title>\n \n To evaluate whether prophylactic oral\n Lactobacillus<\/jats:italic>\n supplementation reduces chemotherapy- and radiotherapy-associated diarrhea and helps preserve quality of life (QoL) in adults starting anticancer treatment.\n <\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n This prospective two-group observational study included adults (18\u201375 years) receiving their first cycle of chemotherapy and\/or radiotherapy at a tertiary cancer center. The Nonprobiotic Group received standard care without probiotics, and the Probiotic Group received standard care plus oral\n Lactobacillus<\/jats:italic>\n 60 million colony-forming units twice daily for 6 weeks. Diarrhea was graded using the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. Use of rescue loperamide, pain on a 10-cm Visual Analog Scale (VAS), and scores on the European Organisation for Research and Treatment of Cancer QoL Questionnaire Core 30 (EORTC QLQ-C30) were recorded at baseline and at 6 weeks.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n One hundred patients completed follow-up (50 per group). At 6 weeks, Grade \u2265 2 diarrhea occurred in 28% of the Nonprobiotic and 4% of the Probiotic Group. Mean diarrhea score was higher without probiotics (1.26 \u00b1 0.49 vs. 0.78 \u00b1 0.51,\n P<\/jats:italic>\n < 0.001), and loperamide use was more frequent (44% vs. 24%,\n P<\/jats:italic>\n = 0.034). VAS pain scores decreased significantly over time in both groups. Physical functioning at 6 weeks was slightly better in the probiotic group, while other EORTC QLQ-C30 domains were broadly comparable.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n Prophylactic\n Lactobacillus<\/jats:italic>\n supplementation was associated with milder treatment-related diarrhoea, reduced rescue loperamide use, and small early gains in physical functioning during chemoradiotherapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijp.ijp_465_25","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:00:19Z","timestamp":1782410419000},"page":"369-374","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Impact of probiotic supplementation on chemotherapy and radiotherapy-associated diarrhea and quality of life"],"prefix":"10.4103","volume":"58","author":[{"given":"Nikhil","family":"Menia","sequence":"first","affiliation":[{"name":"Department of Pharmacology, AIIMS, Vijaypur, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Khajuria","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SMVDIME, Kakryal, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, GMC, Jammu, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucheta","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, GMC, Kathua, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, GMC, Jammu, Jammu and Kashmir, 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systematic reviews and meta-analyses","volume":"130","author":"Amiri Khosroshahi","year":"2023","journal-title":"Br J Nutr"},{"key":"R13-20260626","doi-asserted-by":"crossref","first-page":"101089","DOI":"10.1016\/j.adro.2022.101089","article-title":"Decreasing the adverse effects in pelvic radiation therapy: A randomized controlled trial evaluating the use of probiotics","volume":"8","author":"Ahr\u00e9n","year":"2023","journal-title":"Adv Radiat Oncol"},{"key":"R14-20260626","doi-asserted-by":"crossref","first-page":"04236","DOI":"10.7189\/jogh.14.04236","article-title":"Efficacy of probiotics for treatment of acute or persistent diarrhoea in children from birth till 10 years: Systematic review and meta-analysis","volume":"14","author":"Minaz","year":"2024","journal-title":"J Glob Health"},{"key":"R15-20260626","doi-asserted-by":"crossref","first-page":"929346","DOI":"10.3389\/fmicb.2022.929346","article-title":"How do intestinal probiotics restore the intestinal 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