{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:45:24Z","timestamp":1790473524879,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"\n INTRODUCTION:<\/jats:title>\n \n Phyllanthus niruri<\/jats:italic>\n , a traditional herbal medicine, was found to be hepatoprotective as evidenced by several preclinical and clinical studies. However, to the best of our knowledge, there are no clinical trials available to date to evaluate its efficacy in alcoholic hepatitis.\n <\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n The present study is a block randomized, double-blind, parallel-arm placebo-controlled trial that was designed to assess the efficacy of\n P. niruri<\/jats:italic>\n on the liver and renal function parameters, total oxidant and antioxidant levels in alcoholic hepatitis patients in comparison to placebo over a 4-week period. Patients were screened by CAGE questionnaire, and those with a confirmed diagnosis of mild\u2013moderate alcoholic hepatitis based on laboratory findings and Maddrey's discriminant function score were randomly allocated to treatment and placebo arms. Clinical assessments were done at baseline, 2 weeks, and 4 weeks. A total of 454 patients were screened and 100 eligible patients were recruited for the study, and 71 were analyzed using the modified intention-to-treat approach.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Serum levels of liver and renal function parameters failed to demonstrate significant improvement with\n P. niruri<\/jats:italic>\n . However, there was a statistically significant increase in the level of total antioxidants with\n P. niruri<\/jats:italic>\n (\n P<\/jats:italic>\n = 0.034) with an additional appetite stimulant activity (\n P<\/jats:italic>\n = 0.03) in 4 weeks.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n A 4-week administration of\n P. niruri<\/jats:italic>\n in mild\u2013moderate alcoholic hepatitis patients showed an improvement in the total antioxidant levels with an appetite stimulant activity compared to a placebo.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijp.ijp_540_20","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T23:51:20Z","timestamp":1640821880000},"page":"448-456","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis"],"prefix":"10.4103","volume":"53","author":[{"given":"Karri","family":"Sowjanya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrashekaran","family":"Girish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanaveerappa","family":"Bammigatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakka Chandrasekhar Prasanna","family":"Lakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20240903","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"R3-3-20240903","doi-asserted-by":"crossref","first-page":"85","DOI":"10.33590\/emj\/10312346","article-title":"Alcoholic liver disease: A comprehensive review","volume":"1","author":"Pal","year":"2016","journal-title":"EMJ"},{"key":"R7-3-20240903","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s10620-005-2942-9","article-title":"Herbal medicines for liver diseases","volume":"50","author":"Dhiman","year":"2005","journal-title":"Dig Dis Sci"},{"key":"R8-3-20240903","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/jphp.12565","article-title":"The pharmacological potential of Phyllanthus niruri","volume":"68","author":"Lee","year":"2016","journal-title":"J Pharm Pharmacol"},{"key":"R9-3-20240903","doi-asserted-by":"crossref","first-page":"E902","DOI":"10.3390\/molecules22060902","article-title":"Characterization of metabolite profile in Phyllanthus niruri and correlation with bioactivity elucidated by nuclear magnetic resonance based 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Highly used plant species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae families","volume":"8","author":"Tewari","year":"2017","journal-title":"Front Pharmacol"},{"key":"R24-3-20240903","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1046\/j.1464-410X.2002.02794.x","article-title":"The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation","volume":"89","author":"Freitas","year":"2002","journal-title":"BJU Int"},{"key":"R25-3-20240903","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00240-004-0432-8","article-title":"Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients","volume":"32","author":"Nishiura","year":"2004","journal-title":"Urol Res"},{"key":"R26-3-20240903","first-page":"507","article-title":"Efficacy of Phyllanthus niruri Linn. Extract in the management of type-2 diabetes mellitus associated hypercholesterolemia in mice diabetic model","volume":"4","author":"Rani","year":"2015","journal-title":"Int J Curr Microbiol Appl Sci"},{"key":"R27-3-20240903","first-page":"248","article-title":"Evaluation of antidiabetic potentials of Phyllanthus niruri in alloxan diabetic rats","volume":"9","author":"Okoli","year":"2010","journal-title":"Afr J Biotechnol"},{"key":"R28-3-20240903","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1615\/JEnvironPatholToxicolOncol.v30.i1.50","article-title":"Modulatory influence of Phyllanthus niruri on oxidative stress, antioxidant defence and chemically induced skin tumors","volume":"30","author":"Sharma","year":"2011","journal-title":"J Environ Pathol Toxicol Oncol"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.IJP_540_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:50:32Z","timestamp":1787755832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.IJP_540_20"}},"subtitle":["A double-blind randomized controlled trial"],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_540_20","relation":{},"ISSN":["0253-7613"],"issn-type":[{"value":"0253-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]}}}