{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:53:04Z","timestamp":1791924784879,"version":"4.3.4"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND:<\/jats:title>\n \n Sansevieria trifasciata<\/jats:italic>\n , common name, mother-in-law\u2019s tongue, is a member of the Agavaceae family. We undertook this study to evaluate the cytotoxicity of\n S. trifasciata<\/jats:italic>\n leaf extract against two cancer cell lines as well as its antibacterial activities against six bacterial strains.\n <\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n The investigated cell lines include primary colon epithelial (PCE) cells and human colorectal cancer cells; the studied bacterial strains are\n Staphylococcus aureus, Proteus vulgaris, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa<\/jats:italic>\n , and\n Escherichia coli<\/jats:italic>\n . Using the agar well-diffusion method, various doses (5, 10, and 20 mg\/mL) of plant extracts (ethanol and petroleum ether) were evaluated against each kind of bacterial strain. The minimal inhibitory doses were found using the two-fold serial dilution approach, with a range of 0.156\u20135 mg\/mL.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Comparing extracts of\n S. trifasciata<\/jats:italic>\n leaves to tetracycline (0.05 mg\/mL), a common antibiotic, revealed a wide range of antibacterial activity.\n P<\/jats:italic>\n .\n vulgaris<\/jats:italic>\n and\n S<\/jats:italic>\n .\n aureus<\/jats:italic>\n were the most sensitive bacterial strains to ethanol and petroleum ether extracts, respectively. The MTT test was employed to ascertain the viable cell count of PCE cells and HCT-116. When various ethanol extract concentrations (7.8, 15.63, 31.25, 62.5, 125, 250, 500, and 1000 \u03bcg\/mL) were tested against the cell lines, HCT-116\u2019s IC\n 50<\/jats:sub>\n , values were lower as compared to PCE. The IC\n 50<\/jats:sub>\n values for HCT-116 and PCE cells ranged from 10.0 to 14.07 \u03bcg\/mL and 92.9\u2013216.9 \u03bcg\/mL, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n Ethanolic extract of\n S. trifasciata<\/jats:italic>\n showed promising antibacterial and anticancer properties.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijp.ijp_564_24","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:01:27Z","timestamp":1734411687000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae)"],"prefix":"10.4103","volume":"56","author":[{"given":"Sheryar","family":"Afzal","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, College of Veterinary Medicine, King Faisal University, Hofuf, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Seng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Education, School of Medical and Life Sciences, Sunway University, Selangor, Malaysia"},{"name":"Sunway Microbiome Centre, School of Medical and Life Sciences, Sunway University, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimi Syamaima Abdul","family":"Manap","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, College of Veterinary Medicine, King Faisal University, Hofuf, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Attiq","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Albokhadaim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, College of Veterinary Medicine, King Faisal University, Hofuf, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velaga","family":"Appalaraju","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, MAHSA University, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Magzoub","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Veterinary Medicine, King Faisal University, Hofuf, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olorunfemi","family":"Eseyin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Medicinal Chemistry, University of Uyo, 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