{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:54Z","timestamp":1787169834589,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"\n OBJECTIVES:<\/jats:title>\n The objective of the study is to investigate the risk factors of vancomycin-induced renal toxicity in older adults, especially in those with chronic kidney disease (CKD) Stages 3\u20135.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n In this retrospective observational study, serum vancomycin trough concentrations (VTCs) in patients aged g65 years treated with vancomycin were analyzed, and independent risk factors of vancomycin-induced nephrotoxicity (VIN) were determined by logistic regression analysis.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n In total, 321 patients were included in this study. Serum VTC was an independent risk factor for vancomycin-induced renal toxicity in total cohort (odds ratio [OR], 1.07;\n P<\/jats:italic>\n = 0.004) as well as in the cohort with CKD Stages 3\u20135 (OR, 1.09;\n P<\/jats:italic>\n = 0.010). A daily dose of vancomycin and Charlson comorbidity index was an independent risk factor for vancomycin-induced renal toxicity in total cohort (OR, 3.63;\n P<\/jats:italic>\n = 0.006) and in the cohort with CKD Stage 3\u20135 (OR, 1.83;\n P<\/jats:italic>\n = 0.002), respectively. In older adults with CKD Stages 3a and 3b-5, the VTCs associated with higher risk for vancomycin-induced renal toxicity were 21.5 mg\/L and 16.5 mg\/L, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n In older adults, serum VTC is an independent risk factor for VIN. VTCs over 21.5 mg\/L and 16.5 mg\/L are associated with increased risk of VIN in this population with CKD Stage 3a and 3b-5, respectively.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijp.ijp_634_22","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:54:31Z","timestamp":1691369671000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between vancomycin-induced nephrotoxicity and vancomycin trough concentration in older adults"],"prefix":"10.4103","volume":"55","author":[{"given":"Ning","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20240903","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2147\/CIA.S50238","article-title":"Pharmacodynamics of vanc'omycin in elderly patients aged 75 years or older with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia","volume":"8","author":"Mizokami","year":"2013","journal-title":"Clin Interv Aging"},{"key":"R2-3-20240903","first-page":"21","article-title":"Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American society of health-system pharmacists, 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