{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:56Z","timestamp":1786649816922,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"JOURNAL\/ijpha\/04.03\/01363791-202505000-00004\/figure1\/v\/2026-04-21T054052Z\/r\/image-tiff<\/jats:p>\n \n INTRODUCTION:<\/jats:title>\n \n Alopecia, a common condition causing hair loss, leads to decreased self-esteem worldwide. Natural extracts such as rosemary (\n Rosmarinus officinalis<\/jats:italic>\n L.) and capsicum (\n Capsicum annuum<\/jats:italic>\n L.), traditionally used for various medicinal purposes in Egypt, are widely utilized in treatments for androgenetic alopecia and hair care products. However, these extracts lack market standardization and clear specifications, leading to inconsistent and unpredictable effects.\n <\/jats:p>\n <\/jats:sec>\n \n OBJECTIVES:<\/jats:title>\n This study aims to investigate the effects of standardized rosemary and capsicum extracts on testosterone-induced androgenetic alopecia in rats to ensure consistent quality and safety in marketed hair care products.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n The study involved preparing standardized rosemary and capsicum extracts and developing simple, accurate, sensitive, rapid, and reproducible methods for both. The extracts were tested on adult male Wistar rats with testosterone-induced alopecia, using a 2% finasteride solution as a reference standard. Visual and microscopic evaluations were conducted to measure three hair follicle parameters: diameter, length, and density.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n This study demonstrated the potent effects of standardized rosemary and capsicum extracts on hair growth parameters over 21 days; the application of 0.075% of standardized capsicum extract significantly improved hair growth parameters, including follicle density, length, and diameter. Furthermore, standardized rosemary extracts at 3% and 5% concentrations showed significant improvements across all measured parameters, particularly in hair follicle density.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n This study highlights the potential of standardized rosemary and capsicum extracts in promoting hair growth parameters, including hair follicle density, length, and diameter. It will pave the way for more effective natural-based androgenetic alopecia treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijp.ijp_636_24","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:00:53Z","timestamp":1752073253000},"page":"134-144","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Topical application of standardized capsicum and rosemary extracts promotes hair growth in testosterone induced alopecia in Wistar rats: Histological and morphometric evaluation"],"prefix":"10.4103","volume":"57","author":[{"given":"Alaa Youssef","family":"Eid","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia A.","family":"Al-Mahdy","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab H.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt"},{"name":"Department of Clinical Pharmacy, School of Pharmacy, Nwegiza University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouchira A.","family":"Choucry","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"El-Askary","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.3390\/ijms21155342","article-title":"Hormonal effects on hair follicles","volume":"21","author":"Grymowicz","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"e18743722280092","DOI":"10.2174\/0118743722280092240126053902","article-title":"Insights into alopecia areata: A systematic review of prevalence, pathogenesis, and psychological consequences","volume":"18","author":"Bahashwan","year":"2024","journal-title":"The Open Dermatology Journal"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1111\/jocd.14537","article-title":"Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics","volume":"20","author":"Nestor","year":"2021","journal-title":"J Cosmet Dermatol"},{"key":"R4-20260421","first-page":"15","article-title":"Rosemary oil versus minoxidil 2% for the treatment of androgenetic alopecia: A randomized comparative trial","volume":"13","author":"Panahi","year":"2015","journal-title":"Skinmed"},{"key":"R5-20260421","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/ijms21020523","article-title":"Protective role of nutritional plants containing flavonoids in hair follicle disruption: A review","volume":"21","author":"Bassino","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R6-20260421","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/ptr.4712","article-title":"Promotion of hair growth by Rosmarinus officinalis leaf extract","volume":"27","author":"Murata","year":"2013","journal-title":"Phytother Res"},{"key":"R7-20260421","doi-asserted-by":"crossref","first-page":"2680409","DOI":"10.1155\/2016\/2680409","article-title":"The therapeutic potential of rosemary (Rosmarinus officinalis) diterpenes for Alzheimer\u2019s disease","volume":"2016","author":"Habtemariam","year":"2016","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"R8-20260421","doi-asserted-by":"crossref","first-page":"1700029","DOI":"10.1002\/bies.201700029","article-title":"Oxidative stress management in the hair follicle: Could targeting NRF2 counter age related hair disorders and beyond?","volume":"39","author":"Jadkauskaite","year":"2017","journal-title":"BioEssays"},{"key":"R9-20260421","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/BF02850093","article-title":"Essential oils and low-intensity electromagnetic pulses in the treatment of androgen-dependent alopecia","volume":"20","author":"Bureau","year":"2003","journal-title":"Adv Ther"},{"key":"R10-20260421","first-page":"451","article-title":"The effect of coapplication of capsaicin and minoxidil on murine hair growth","volume":"41","author":"Lee","year":"2003","journal-title":"Korean Journal of Dermatology"},{"key":"R11-20260421","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/ptr.7660","article-title":"Capsicum annuum L. and its bioactive constituents: A critical review of a traditional culinary spice in terms of its modern pharmacological potentials with toxicological issues","volume":"37","author":"Mandal","year":"2023","journal-title":"Phytother Res"},{"key":"R12-20260421","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ghir.2007.04.009","article-title":"Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia","volume":"17","author":"Harada","year":"2007","journal-title":"Growth Horm IGF Res"},{"key":"R13-20260421","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1089\/jmf.2021.0156","article-title":"A comprehensive review of natural alternatives for treatment of alopecia with an overview of market products","volume":"25","author":"Youssef","year":"2022","journal-title":"J Med Food"},{"key":"R14-20260421","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1021\/jf8040287","article-title":"Determination of capsinoids by HPLC-DAD in capsicum species","volume":"57","author":"Singh","year":"2009","journal-title":"J Agric Food Chem"},{"key":"R15-20260421","doi-asserted-by":"crossref","first-page":"8919","DOI":"10.3390\/molecules16108919","article-title":"Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography","volume":"16","author":"Al Othman","year":"2011","journal-title":"Molecules"},{"key":"R16-20260421","doi-asserted-by":"crossref","first-page":"111241","DOI":"10.1016\/j.biopha.2021.111241","article-title":"Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase","volume":"136","author":"Wang","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"R17-20260421","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/cdr.cdr_29_21","article-title":"Pathogenesis of androgenetic alopecia","volume":"6","author":"Kidangazhiathmana","year":"2022","journal-title":"Clin Derm Rev"},{"key":"R18-20260421","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/jmf.2023.0117","article-title":"Evaluation of hair growth promoting activity of standardized soybean extract on testosterone-induced alopecia","volume":"28","author":"Youssef","year":"2025","journal-title":"Journal of Medicinal Food"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_636_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:43Z","timestamp":1786647523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_636_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_636_24","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-07-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}