{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:17:35Z","timestamp":1787840255432,"version":"build-2784847793"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>Olanzapine is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and depression. Despite proven efficacy in these disorders, it can cause various side effects, including occurrences of paraesthesia\u2013a sensory disorder characterized by spontaneous itching or tingling without external triggers. The mechanism behind olanzapine-induced paraesthesia is not well understood but may involve dopamine D2 and serotonin 5-HT2A and 5-HT2C receptor antagonism. Here, we report two cases of severe paraesthesia that occurred as a side effect of olanzapine therapy, which improved after discontinuing the medication in the first case and by reducing the dose in the second case.<\/jats:p>","DOI":"10.4103\/ijp.ijp_637_24","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T03:00:06Z","timestamp":1749783606000},"page":"102-103","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Olanzapine-induced paraesthesia: A less reported side effect"],"prefix":"10.4103","volume":"57","author":[{"given":"Sanyam","family":"Tyagi","sequence":"first","affiliation":[{"name":"Department of Psychiatry, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay Kumar","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmanpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"R2-20250613","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0920-9964(98)00146-7","article-title":"Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro","volume":"37","author":"Bymaster","year":"1999","journal-title":"Schizophr Res"},{"key":"R3-20250613","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/00004714-199612000-00007","article-title":"Risperidone-associated burning paraesthesia","volume":"16","author":"Heimberg","year":"1996","journal-title":"J Clin Psychopharmacol"},{"key":"R4-20250613","doi-asserted-by":"crossref","first-page":"9532","DOI":"10.3390\/ijms21249532","article-title":"Mechanism of action of atypical antipsychotic drugs in mood disorders","volume":"21","author":"Grinchii","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R5-20250613","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4103\/0253-7613.135965","article-title":"Olanzapine-induced restless leg syndrome:A case report and review of literature","volume":"46","author":"Basu","year":"2014","journal-title":"Indian J Pharmacol"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_637_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:34Z","timestamp":1787836714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_637_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_637_24","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-07-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}