{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:18:47Z","timestamp":1790983127709,"version":"4.1.0"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare, potentially fatal adverse drug reaction (ADR) most associated with anticonvulsants. Paediatric cases are uncommon and may present with atypical or early onset, posing diagnostic challenges. We report the case of a 10-year-old boy who developed high-grade fever, generalized maculopapular rash, lymphadenopathy, eosinophilia, and hepatic involvement shortly after initiation of phenytoin for epilepsy. Infectious causes were excluded. The patient fulfilled RegiSCAR criteria for definite DRESS (score = 7). Prompt withdrawal of phenytoin and initiation of systemic corticosteroids resulted in complete recovery. This case highlights the importance of early recognition of DRESS syndrome as a serious ADR, even when onset occurs earlier than the classical latency period.<\/jats:p>","DOI":"10.4103\/ijp.ijp_65_26","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:00:23Z","timestamp":1782410423000},"page":"478-480","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Phenytoin-induced drug rash with eosinophilia and systemic symptoms syndrome in a child: A rare but serious adverse drug reaction"],"prefix":"10.4103","volume":"58","author":[{"given":"H. S.","family":"Rajani","sequence":"first","affiliation":[{"name":"Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Narayanappa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Prashanth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chandrashekhar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"R1-20260626","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S1085-5629(96)80038-1","article-title":"Drug-induced pseudolymphoma and drug hypersensitivity syndrome (DRESS)","volume":"15","author":"Bocquet","year":"1996","journal-title":"Semin Cutan Med Surg"},{"key":"R2-20260626","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.amjmed.2011.01.017","article-title":"The DRESS syndrome: A literature review","volume":"124","author":"Cacoub","year":"2011","journal-title":"Am J Med"},{"key":"R3-20260626","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2133.2006.07704.x","article-title":"Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?","volume":"156","author":"Kardaun","year":"2007","journal-title":"Br J Dermatol"},{"key":"R4-20260626","first-page":"75","article-title":"Phenytoin-induced DRESS syndrome","volume":"44","author":"Lindsay","year":"2013","journal-title":"J Emerg Med"},{"key":"R5-20260626","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2332\/allergolint.55.1","article-title":"Drug-induced hypersensitivity syndrome","volume":"55","author":"Shiohara","year":"2006","journal-title":"Allergol Int"},{"key":"R6-20260626","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1365-2133.2007.08167.x","article-title":"HHV-6 reactivation in DRESS","volume":"157","author":"Tohyama","year":"2007","journal-title":"Br J Dermatol"},{"key":"R7-20260626","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"R8-20260626","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2165\/00002018-199717060-00004","article-title":"Causal or casual? The role of causality assessment in pharmacovigilance","volume":"17","author":"Meyboom","year":"1997","journal-title":"Drug Saf"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_65_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:26:55Z","timestamp":1787747215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_65_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_65_26","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}