{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:55Z","timestamp":1786649815415,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Dried Embelia ribes berries can be used to extract Embelin (2,5-Dihydroxy-3-undecylcyclohexa-2,5-diene -1,4-dione), a herbal p-benzoquinone derived from general quinones. This plant shows potential for scientific study that could provide cutting-edge therapeutic compounds. Prior studies have shown that the molecule's transformation into a complex may have increased its bioactivity. Furthermore, it has been shown that inorganic complexes are more versatile than pure organic molecules, which may improve the ability to target sites that are commonly present in the aquatic ecological environment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>One of the substances with known activity found in the fruits of Embelia ribes, embelin (2, 5-dihydroxy-3- undecyl-p-benzoquinone), was extracted using chloroform solvent and then separated using column chromatography techniques. An Embelin-Sn complex was created using the purified Embelin. The Embelin-Sn complex was synthesized under simple, appropriate conditions that employed room temperature. Using elemental analysis, infrared spectroscopy, mass spectrum analysis, and Proton Nuclear Magnetic Resonance (1H NMR) spectroscopy, the structure of the Embelin-Sn complex has been ascertained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The phytochemical embelin isolated from Embelia ribes was used to synthesize Embelin-Sn complex, its characterization studied, and its anticancer potential evaluated using the MTT assay and apoptotic assay on the T-47D breast cancer cell line and antibacterial study by disc diffusion method. Sn complex concentration on breast cancer cells (T-47D cell line) were exposed to varied concentrations for 24 hours, including 40, 60, 80, 100, and 120 mg\/ml. This result implies that embelin inhibits the proliferation of breast cancer cells. The antibacterial property was determined by measuring the disc's inhibitory zone size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>For the first time, an Embelin-Sn complex was synthesized, and it exhibited zone of inhibition against E. coli and dose-dependent administration of Embelin-Sn complex represents a potential novel strategy which can successfully treat the breast cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_678_23","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:00:36Z","timestamp":1752073236000},"page":"166-172","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic potential of novel tin metal complex of embelin isolated from Embelia ribes fruits"],"prefix":"10.4103","volume":"57","author":[{"given":"Ruchi","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Chemistry, IIS (Deemed to be University), Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durga K.","family":"Mewara","sequence":"additional","affiliation":[{"name":"Department of Chemistry, MDS University, Ghooghra, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1039\/B514173G","article-title":"Equilibrium and NMR studies on GdIII, YIII, CuII and ZnII complexes of various DTPA-N, N\u201d-bis(amide) ligands. Kinetic stabilities of the gadolinium(III) complexes","volume":"8","author":"J\u00e1szber\u00e9nyi","year":"2006","journal-title":"Dalton Trans"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"10368","DOI":"10.1021\/ja00075a066","article-title":"Gadolinium(III) texaphyrin: A novel MRI contrast agent","volume":"115","author":"Sessler","year":"1993","journal-title":"J Am Chem Soc"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1021\/ja9609314","article-title":"Novel preorganized hemispherands to encapsulate rare earth ions: A shielding and ligand deuteration for prolonged lifetimes of excited Eu3+Ions","volume":"119","author":"Oude Wolbers","year":"1997","journal-title":"J Am Chem Soc"},{"key":"R4-20260421","first-page":"220","article-title":"Studies on the solution equilibria involved in some Co(II) and Zn(II) Schiff base complexes systems","volume":"77","author":"Nair","year":"2000","journal-title":"Ind J Chem Soc"},{"key":"R6-20260421","first-page":"213","article-title":"Toxicity studies with potassium embelate. a new analgesic compound","volume":"28","author":"Johri","year":"1980","journal-title":"Indian J Exp Biol"},{"key":"R7-20260421","first-page":"1","article-title":"Antifertility activity of\u2019 Embelia ribes","volume":"6","author":"Arora","year":"1971","journal-title":"Indian J Med Res"},{"key":"R8-20260421","first-page":"23","article-title":"Ethnopharmacological uses of Embelia ribes Burm. F. \u2013 A review","volume":"9","author":"Souravi","year":"2014","journal-title":"J Pharm Biol Sci"},{"key":"R9-20260421","first-page":"1252","article-title":"Determination of nutritive value and analysis of mineral elements for some medicinally valued plants from Uttaranchal","volume":"89","author":"Indryan","year":"2005","journal-title":"Curr Sci"},{"key":"R10-20260421","first-page":"2320","article-title":"Importance of Embelia ribes: An update","volume":"4","author":"Lal","year":"2013","journal-title":"Int J Pharm Sci"},{"key":"R11-20260421","first-page":"108","article-title":"Ethnopharmacological uses of Embelia ribes burm. F. \u2013 A review","volume":"7","author":"Somesh","year":"2021","journal-title":"World J Pharm Med Res"},{"key":"R12-20260421","first-page":"668","article-title":"A review on pharmacological properties of Embelia ribes (Vayavidnag)","volume":"6","author":"Bashir","year":"2019","journal-title":"J Emerg Technol Innov Res"},{"key":"R13-20260421","first-page":"1229","article-title":"Embelia ribes: A valuable medicinal plant","volume":"8","author":"Bist","year":"2016","journal-title":"J Chem Pharm Res"},{"key":"R14-20260421","first-page":"34","article-title":"Review on pharmacological and phytochemistry of Embelia ribes plant","volume":"2","author":"Wankhade","year":"2021","journal-title":"Int J Pharmacogn Phytochem Res"},{"key":"R15-20260421","first-page":"190","article-title":"Pharmacognostical and phytochemical profile of vidanga (Embelia ribes) seeds \u2013 A review","volume":"7","author":"Debbarma","year":"2018","journal-title":"World J Pharm Pharm Sci"},{"key":"R16-20260421","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1080\/14786419.2021.1955361","article-title":"A comprehensive insight on the biological potential of embelin and its derivatives","volume":"36","author":"Basha","year":"2022","journal-title":"Nat Prod Res"},{"key":"R17-20260421","first-page":"661","article-title":"Plant secondary metabolites: A review","volume":"3","author":"Tiwari","year":"2015","journal-title":"Int J Eng Res Generic Sci"},{"key":"R18-20260421","doi-asserted-by":"crossref","first-page":"960674","DOI":"10.3389\/fnut.2022.960674","article-title":"Biofabrication of silver nanoparticles (AgNPs) using embelin for effective therapeutic management of lung cancer","volume":"9","author":"Jagtap","year":"2022","journal-title":"Front Nutr"},{"key":"R19-20260421","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.5958\/0974-360X.2019.00702.9","article-title":"In-vitro antioxidant and cytotoxic activities of silver nanoparticles of embelin isolated from Embelia ribes","volume":"12","author":"Othman","year":"2019","journal-title":"Res J Pharm Tech"},{"key":"R20-20260421","first-page":"3534","article-title":"In vitro cytotoxic potential of selenium nanoparticles biosynthesized using Embelia ribes fruits","volume":"10","author":"Rutika","year":"2021","journal-title":"J Med Pharm Allied Sci"},{"key":"R21-20260421","first-page":"55","article-title":"Pharmacological review of Adhatoda zeylanica and Embelia ribes","volume":"4","author":"Biradar","year":"2010","journal-title":"Front Nutr"},{"key":"R22-20260421","first-page":"187","article-title":"Nature and composition of La(III), Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Dy(III) and Ho(III) complexes of embelin. Inorganica Chim","volume":"117","author":"Dhar","year":"1986","journal-title":"Acta"},{"key":"R23-20260421","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.matpr.2020.10.168","article-title":"Synthesis of embelin-Fe complex from Embelia ribes fruits and characterization","volume":"40","author":"Arthanareeswari","year":"2020","journal-title":"Mater Today Proc"},{"key":"R24-20260421","first-page":"916","article-title":"Chemical speciation of binary complexes of embelin with some biologically important metal ions","volume":"57","author":"Rani","year":"2010","journal-title":"Acta Chim Slov"},{"key":"R25-20260421","first-page":"23","article-title":"2, 5-dihydroxy-3-undecyl, 1,4-benzoquinone (embelin)-a second solid gold of India- a review","volume":"6","author":"Radhakrishnan","year":"2014","journal-title":"Int J Pharm Pharm Sci"},{"key":"R26-20260421","first-page":"259","article-title":"Vilangin A new constituent of Embelia ribes and E. robusta","volume":"30","author":"Venkateswarlu","year":"1961","journal-title":"Curr Sci"},{"key":"R27-20260421","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11095-011-0510-x","article-title":"Opsonization, biodistribution, cellular uptake and apoptosis study of PEGylated PBCA nanoparticle as potential drug delivery carrier","volume":"29","author":"Chaudhari","year":"2012","journal-title":"Pharm Res"},{"key":"R28-20260421","first-page":"295","article-title":"Synthesis and characterization of zinc(ii) and copper(ii) complexes of embelin","volume":"19","author":"Cherutoi","year":"2005","journal-title":"Chem Soc Ethiop"},{"key":"R29-20260421","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0006-2952(01)00785-7","article-title":"Gene expression microarray analysis in cancer biology, pharmacology, and drug development: Progress and potential","volume":"62","author":"Clarke","year":"2001","journal-title":"Biochem Pharmacol"},{"key":"R30-20260421","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.1007\/s11164-014-1806-3","article-title":"Synthesis, characterization, in vitro antimicrobial and anticancer evaluation of random copolyesters bearing biscoumarin units in the main chains","volume":"41","author":"Kandaswamy","year":"2015","journal-title":"Res Chem Intermediates"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_678_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:43Z","timestamp":1786647523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_678_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_678_23","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2023-10-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}