{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:38:50Z","timestamp":1786736330254,"version":"build-2736575974"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Pharmacol"],"published-print":{"date-parts":[[2019]]},"DOI":"10.4103\/ijp.ijp_679_19","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T04:13:27Z","timestamp":1574655207000},"page":"359","source":"Crossref","is-referenced-by-count":1,"title":["Novel targets for drug discovery in celiac disease"],"prefix":"10.4103","volume":"51","author":[{"given":"Bikash","family":"Medhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RahulSoloman","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitika","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0253-7613.271642-1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: Systematic review and meta-analysis","author":"Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key-10.4103\/0253-7613.271642-2","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1440-1746.2010.06606.x","article-title":"Prevalence of celiac disease in the northern part of India: A community based study","author":"Makharia","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"key-10.4103\/0253-7613.271642-3","first-page":"582","article-title":"Emerging therapeutic options for celiac disease: Potential alternatives to a gluten-free diet","author":"Bakshi","year":"2012","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"key-10.4103\/0253-7613.271642-4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/physrev.00003.2008","article-title":"Zonulin and its regulation of intestinal barrier function: The biological door to inflammation, autoimmunity, and cancer","author":"Fasano","year":"2011","journal-title":"Physiol Rev"},{"key":"key-10.4103\/0253-7613.271642-5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2036.2007.03413.x","article-title":"The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: A proof of concept study","author":"Paterson","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"key-10.4103\/0253-7613.271642-6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1172\/JCI119271","article-title":"Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model","author":"Fasano","year":"1997","journal-title":"J Clin Invest"},{"key":"key-10.4103\/0253-7613.271642-7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1749-6632.2012.06538.x","article-title":"Zonulin, regulation of tight junctions, and autoimmune diseases","author":"Fasano","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"key-10.4103\/0253-7613.271642-8","doi-asserted-by":"crossref","first-page":"e15949","DOI":"10.1097\/MD.0000000000015949","article-title":"The role of CXCR3 and its ligands CXCL10 and CXCL11 in the pathogenesis of celiac disease","author":"Haghbin","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"key-10.4103\/0253-7613.271642-9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1084\/jem.20071204","article-title":"Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease","author":"Matysiak-Budnik","year":"2008","journal-title":"J Exp Med"},{"key":"key-10.4103\/0253-7613.271642-10","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/j.gastro.2014.02.031","article-title":"Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease","author":"L\u00e4hdeaho","year":"2014","journal-title":"Gastroenterology"},{"key":"key-10.4103\/0253-7613.271642-11","first-page":"187","article-title":"Vaccine immunotherapy for celiac disease","author":"Di","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"key-10.4103\/0253-7613.271642-12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.smim.2015.11.001","article-title":"Celiac disease: Autoimmunity in response to food antigen","author":"Stamnaes","year":"2015","journal-title":"Semin Immunol"},{"key":"key-10.4103\/0253-7613.271642-13","first-page":"1585","article-title":"Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity","author":"van","year":"1998","journal-title":"J Immunol"},{"key":"key-10.4103\/0253-7613.271642-14","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.4049\/jimmunol.163.8.4277","article-title":"A soluble factor produced by lamina propria mononuclear cells is required for TNF-alpha enhancement of IFN-gamma production by T cells","author":"Prehn","year":"1999","journal-title":"J Immunol"},{"key":"key-10.4103\/0253-7613.271642-15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fmed.2017.00137","article-title":"New insights into the pathogenesis of celiac disease","author":"De","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"key-10.4103\/0253-7613.271642-16","first-page":"1480","article-title":"Coeliac disease","author":"Di","year":"2009","journal-title":"Lancet"},{"key":"key-10.4103\/0253-7613.271642-17","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nri2670","article-title":"Tissue-mediated control of immunopathology in coeliac disease","author":"Jabri","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"key-10.4103\/0253-7613.271642-18","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-2036.2012.05013.x","article-title":"Review article: Coeliac disease, new approaches to therapy","author":"Rashtak","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"key-10.4103\/0253-7613.271642-19","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1016\/j.bmc.2007.07.001","article-title":"Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease","author":"Xia","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"key-10.4103\/0253-7613.271642-20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1074-7613(00)80021-7","article-title":"Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in Cathepsin S null mice","author":"Nakagawa","year":"1999","journal-title":"Immunity"},{"key":"key-10.4103\/0253-7613.271642-21","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3389\/fimmu.2017.00806","article-title":"Pharmacodynamic monitoring of ro5459072, a small molecule inhibitor of Cathepsin S","author":"Theron","year":"2017","journal-title":"Front Immunol"},{"key":"key-10.4103\/0253-7613.271642-22","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s10875-012-9745-5","article-title":"Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease.A proof-of-concept study?","author":"Rauhavirta","year":"2013","journal-title":"J Clin Immunol"},{"key":"key-10.4103\/0253-7613.271642-23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/emmm.201000084","article-title":"Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease","author":"McConoughey","year":"2010","journal-title":"EMBO Mol Med"},{"key":"key-10.4103\/0253-7613.271642-24","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/gut.36.6.874","article-title":"Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon gamma antibody","author":"Przemioslo","year":"1995","journal-title":"Gut"},{"key":"key-10.4103\/0253-7613.271642-25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bpg.2015.05.001","article-title":"Innate immunity: Actuating the gears of celiac disease pathogenesis","author":"Kim","year":"2015","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"key-10.4103\/0253-7613.271642-26","doi-asserted-by":"crossref","first-page":"20518","DOI":"10.3390\/ijms151120518","article-title":"Gliadin peptides as triggers of the proliferative and stress\/innate immune response of the celiac small intestinal mucosa","author":"Barone","year":"2014","journal-title":"Int J Mol Sci"},{"key":"key-10.4103\/0253-7613.271642-27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.febslet.2004.06.057","article-title":"Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB","author":"Jel\u00ednkov\u00e1","year":"2004","journal-title":"FEBS Lett"},{"key":"key-10.4103\/0253-7613.271642-28","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1053\/gast.2002.31874","article-title":"Successful infliximab treatment for steroid-refractory celiac disease: A case report","author":"Gillett","year":"2002","journal-title":"Gastroenterology"},{"key":"key-10.4103\/0253-7613.271642-29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.dld.2006.10.017","article-title":"Treatment of life-threatening type I refractory coeliac disease with long-term infliximab","author":"Costantino","year":"2008","journal-title":"Dig Liver Dis"},{"key":"key-10.4103\/0253-7613.271642-30","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.gcb.2009.07.007","article-title":"Celiac disease in 2009: A future without gluten-free diet.?","author":"Malamut","year":"2009","journal-title":"Gastroenterol Clin Biol"},{"key":"key-10.4103\/0253-7613.271642-31","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S2468-1253(19)30264-X","article-title":"Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: A phase 2a, randomised, double-blind, placebo-controlled study","author":"L\u00e4hdeaho","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"key-10.4103\/0253-7613.271642-32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/jmf.2017.0018","article-title":"Amylase-trypsin inhibitors in wheat and other cereals as potential activators of the effects of nonceliac gluten sensitivity","author":"Reig-Otero","year":"2018","journal-title":"J Med Food"},{"key":"key-10.4103\/0253-7613.271642-33","first-page":"CD006097","article-title":"Natalizumab for induction of remission in Crohn's disease","author":"Nelson","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"key-10.4103\/0253-7613.271642-34","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s10620-015-4020-2","article-title":"Gut microbiota and celiac disease","author":"Marasco","year":"2016","journal-title":"Dig Dis Sci"},{"key":"key-10.4103\/0253-7613.271642-35","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/MPG.0b013e318241cfa8","article-title":"Expression of microbiota, toll-like receptors, and their regulators in the small intestinal mucosa in celiac disease","author":"Kalliom\u00e4ki","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"key-10.4103\/0253-7613.271642-36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","author":"Kamada","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"key-10.4103\/0253-7613.271642-37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","author":"Kumar","year":"2011","journal-title":"Int Rev Immunol"},{"key":"key-10.4103\/0253-7613.271642-38","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2982.2012.01921.x","article-title":"Intestinal barrier function in health and gastrointestinal disease","author":"Camilleri","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"key-10.4103\/0253-7613.271642-39","doi-asserted-by":"crossref","first-page":"735","DOI":"10.5858\/arpa.2011-0572-RA","article-title":"An update on celiac disease histopathology and the road ahead","author":"Bao","year":"2012","journal-title":"Arch Pathol Lab Med"},{"key":"key-10.4103\/0253-7613.271642-40","first-page":"7587095","article-title":"Diverse profiles of toll-like receptors 2, 4, 7, and 9 mRNA in peripheral blood and biopsy specimens of patients with celiac disease","author":"Ghasiyari","year":"2018","journal-title":"J Immunol Res"},{"key":"key-10.4103\/0253-7613.271642-41","doi-asserted-by":"crossref","unstructured":"Wu F, Zikusoka M, Trindade A, Dassopoulos T, Harris ML, Bayless TM, et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology 2008;135:1624-.635E+27.","DOI":"10.1053\/j.gastro.2008.07.068"},{"key":"key-10.4103\/0253-7613.271642-42","doi-asserted-by":"crossref","first-page":"e29094","DOI":"10.1371\/journal.pone.0029094","article-title":"MicroRNA-449a overexpression, reduced NOTCH1 signals and scarce goblet cells characterize the small intestine of celiac patients","author":"Capuano","year":"2011","journal-title":"PLoS One"},{"key":"key-10.4103\/0253-7613.271642-43","doi-asserted-by":"crossref","first-page":"e73683","DOI":"10.1371\/journal.pone.0073683","article-title":"Candidate microRNA biomarkers in human gastric cancer: A systematic review and validation study","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"key-10.4103\/0253-7613.271642-44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/CS20130248","article-title":"microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts","author":"Vaira","year":"2014","journal-title":"Clin Sci (Lond)"},{"key":"key-10.4103\/0253-7613.271642-45","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/jcp.2008.061366","article-title":"Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease","author":"Collado","year":"2009","journal-title":"J Clin Pathol"},{"key":"key-10.4103\/0253-7613.271642-46","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1099\/jmm.0.47410-0","article-title":"Imbalance in the composition of the duodenal microbiota of children with coeliac disease","author":"Nadal","year":"2007","journal-title":"J Med Microbiol"},{"key":"key-10.4103\/0253-7613.271642-47","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/jcp.2010.076950","article-title":"Intestinal Bacteroides species associated with coeliac disease","author":"S\u00e1nchez","year":"2010","journal-title":"J Clin Pathol"},{"key":"key-10.4103\/0253-7613.271642-48","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1128\/AEM.00869-13","article-title":"Duodenal-mucosal bacteria associated with celiac disease in children","author":"S\u00e1nchez","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"key-10.4103\/0253-7613.271642-49","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1399-0039.2011.01791.x","article-title":"Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk","author":"Einarsdottir","year":"2011","journal-title":"Tissue Antigens"},{"key":"key-10.4103\/0253-7613.271642-50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ng.543","article-title":"Multiple common variants for celiac disease influencing immune gene expression","author":"Dubois","year":"2010","journal-title":"Nat Genet"},{"key":"key-10.4103\/0253-7613.271642-51","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/ni.1768","article-title":"Themis, a T cell-specific protein important for late thymocyte development","author":"Lesourne","year":"2009","journal-title":"Nat Immunol"},{"key":"key-10.4103\/0253-7613.271642-52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nature12718","article-title":"Themis sets the signal threshold for positive and negative selection in T-cell development","author":"Fu","year":"2013","journal-title":"Nature"},{"key":"key-10.4103\/0253-7613.271642-53","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1128\/MCB.25.11.4703-4715.2005","article-title":"Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} function","author":"Wang","year":"2005","journal-title":"Mol Cell Biol"},{"key":"key-10.4103\/0253-7613.271642-54","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00335-007-9062-0","article-title":"A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat","author":"Asano","year":"2007","journal-title":"Mamm Genome"},{"key":"key-10.4103\/0253-7613.271642-55","first-page":"1","article-title":"Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding","author":"Sap","year":"1994","journal-title":"Mol Cell Biol"},{"key":"key-10.4103\/0253-7613.271642-56","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1074\/jbc.270.9.4640","article-title":"Sequence and expression of a candidate for the human secretor blood group alpha (1,2) fucosyltransferase gene (FUT2).Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype","author":"Kelly","year":"1995","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0253-7613.271642-57","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bpg.2015.04.005","article-title":"Therapeutic approaches for celiac disease","author":"Plugis","year":"2015","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"key-10.4103\/0253-7613.271642-58","first-page":"214","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","author":"International","year":"2011","journal-title":"Nature"},{"key":"key-10.4103\/0253-7613.271642-59","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0140-6736(11)60874-X","article-title":"Identification of IL6R and chromosome 11q13.5 as risk loci for asthma","author":"Ferreira","year":"2011","journal-title":"Lancet"},{"key":"key-10.4103\/0253-7613.271642-60","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci","author":"Franke","year":"2010","journal-title":"Nat Genet"},{"key":"key-10.4103\/0253-7613.271642-61","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature12199","article-title":"BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis","author":"Roychoudhuri","year":"2013","journal-title":"Nature"},{"key":"key-10.4103\/0253-7613.271642-62","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1056\/NEJMoa0807917","article-title":"Shared and distinct genetic variants in type 1 diabetes and celiac disease","author":"Smyth","year":"2008","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0253-7613.271642-63","first-page":"621","article-title":"Evidence for polygenic susceptibility to multiple sclerosis-the shape of things to come","author":"International","year":"2010","journal-title":"Am J Hum Genet"},{"key":"key-10.4103\/0253-7613.271642-64","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ng.102","article-title":"Newly identified genetic risk variants for celiac disease related to the immune response","author":"Hunt","year":"2008","journal-title":"Nat Genet"},{"key":"key-10.4103\/0253-7613.271642-65","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.4049\/jimmunol.164.4.1829","article-title":"Regulator of G protein signaling 1 (RGS1) markedly impairs Gi alpha signaling responses of B lymphocytes","author":"Moratz","year":"2000","journal-title":"J Immunol"},{"key":"key-10.4103\/0253-7613.271642-66","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1128\/MCB.24.13.5767-5775.2004","article-title":"Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-\/- mice","author":"Moratz","year":"2004","journal-title":"Mol Cell Biol"},{"key":"key-10.4103\/0253-7613.271642-67","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.4049\/jimmunol.1100833","article-title":"Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential","author":"Gibbons","year":"2011","journal-title":"J Immunol"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:40:27Z","timestamp":1786732827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.IJP_679_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019]]}},"alternative-id":["271642"],"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_679_19","relation":{},"ISSN":["0253-7613"],"issn-type":[{"value":"0253-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}