{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:18:56Z","timestamp":1788437936207,"version":"build-2803163510"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>Paraquat is a highly toxic bipyridyl herbicide that continues to be used in several countries despite restrictions elsewhere. While ingestion is the most common route of poisoning, intravenous administration is rare and associated with extremely high mortality. We report the case of a 26-year-old male who attempted suicide by self-injecting 10 mL of 24% paraquat dichloride intravenously into the dorsal metacarpal region. Within hours, he developed hematemesis, diaphoresis, giddiness, chills, agitation, and diffuse burning sensations. On admission, he was alert but drowsy with bradycardia, pedal edema, and local swelling at the injection site. Laboratory findings revealed leukocytosis, elevated serum creatinine, hypokalemia, and metabolic acidosis. Despite early hemodialysis, continuous renal replacement therapy, and administration of antioxidants and supportive treatment, the patient developed progressive respiratory distress, refractory hypotension, and recurrent cardiac arrests. He died 28 h after admission. Intravenous paraquat poisoning is rare but uniformly fatal. This case emphasizes the importance of early recognition, aggressive supportive care, and the continued need for preventive strategies and regulatory measures to limit paraquat availability.<\/jats:p>","DOI":"10.4103\/ijp.ijp_81_26","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:01:00Z","timestamp":1788354060000},"page":"597-601","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A rare intravenous paraquat exposure presenting with novel and atypical severe clinical manifestations"],"prefix":"10.4103","volume":"58","author":[{"given":"Vrushali M.","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirish Shantaram","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil Sunil","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipak Pralhad","family":"Mali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Quality Assurance, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"R1-20260903","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1365-2125.2011.04026.x","article-title":"Medical management of paraquat ingestion","volume":"72","author":"Gawarammana","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"R2-20260903","first-page":"S263","article-title":"Paraquat: The poison potion","volume":"23","author":"Sukumar","year":"2019","journal-title":"Indian J Crit Care Med"},{"key":"R3-20260903","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10408440701669959","article-title":"Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment","volume":"38","author":"Dinis-Oliveira","year":"2008","journal-title":"Crit Rev Toxicol"},{"key":"R4-20260903","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.freeradbiomed.2010.12.035","article-title":"Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase","volume":"50","author":"Fussell","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"R5-20260903","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0300-483X(02)00382-7","article-title":"Role of antioxidants in paraquat toxicity","volume":"180","author":"Suntres","year":"2002","journal-title":"Toxicology"},{"key":"R6-20260903","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/jcp.28.Suppl_9.81","article-title":"The pathology of the lung in paraquat poisoning","volume":"9","author":"Smith","year":"1975","journal-title":"J Clin Pathol Suppl (R Coll Pathol)"},{"key":"R7-20260903","doi-asserted-by":"crossref","first-page":"203","DOI":"10.15171\/jrip.2016.43","article-title":"Acute kidney injury in patients with paraquat intoxication; 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