{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:27:36Z","timestamp":1786739256546,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Heparin, a commonly used anticoagulant, has been associated with several cutaneous adverse effects, including skin necrosis, bruising\/ecchymosis, urticaria, angioedema, red plaques, nodular lesions, and allergic contact dermatitis. Bullous hemorrhagic dermatosis (BHD) caused by heparin is a rare skin-related side effect. A 34-year-old woman diagnosed with anti-phospholipid syndrome was recently observed to develop hemorrhagic bullous dermatosis distant from the site of intravenous unfractionated heparin. Heparin therapy was continued for 5 days, followed by daily oral warfarin 2 mg, along with aspirin 75 mg, with monitoring of lesions. Two weeks later, skin lesions resolved spontaneously. BHD is nonthreatening and typically resolves on its own without the need for extensive treatment. Clinicians should be aware of the presentations of this self-limiting illness to avoid unnecessary workups.<\/jats:p>","DOI":"10.4103\/ijp.ijp_821_23","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T11:00:15Z","timestamp":1753095615000},"page":"276-278","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Bullous hemorrhagic dermatosis following unfractionated heparin therapy"],"prefix":"10.4103","volume":"57","author":[{"given":"Jitendra","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"},{"name":"Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Dinkar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"},{"name":"Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1365-2230.2012.04395.x","article-title":"Cutaneous adverse events associated with heparin","volume":"37","author":"Maldonado Cid","year":"2012","journal-title":"Clin Exp Dermatol"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.jaad.2005.01.098","article-title":"Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: Three cases","volume":"54","author":"Perrinaud","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40164-018-0108-7","article-title":"Bullous hemorrhagic dermatosis is an under-recognized side effect of full dose low-molecular weight heparin: A case report and review of the literature","volume":"7","author":"Russo","year":"2018","journal-title":"Exp Hematol Oncol"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1590\/abd1806-4841.20165418","article-title":"Heparin induced bullous hemorrhagic dermatosis at a site distant from the injection. 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