{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:44:08Z","timestamp":1790390648173,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This study evaluated the efficacy of intraperitoneal magnesium sulfate (MgSO\n                      <jats:sub>4<\/jats:sub>\n                      ) in preventing postoperative pain after elective laparoscopic cholecystectomy (LC). It is a prospective, double-blinded, placebo-controlled, randomized trial which included 64 patients who underwent LC. Patients were equally randomized into Groups A and B. MgSO\n                      <jats:sub>4<\/jats:sub>\n                      and normal saline were instilled in subdiaphragmatic space in Groups A and B, respectively, after creating pneumoperitoneum and before starting dissection. The Visual analogue Scale (VAS) was used to determine postoperative pain. Patients who received intraperitoneal MgSO\n                      <jats:sub>4<\/jats:sub>\n                      had lower average VAS scores for the first 6 h postoperatively, and also, the time for the requirement of first analgesic was longer (3.6 \u00b1 0.4 vs. 2.3 \u00b1 1.0 h). The incidence of vomiting and the requirement for rescue antiemetic was also lower in Group A. Intraperitoneal instillation of MgSO\n                      <jats:sub>4<\/jats:sub>\n                      reduces postoperative pain and vomiting following elective LC without incurring additional side effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_827_22","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:54:31Z","timestamp":1691369671000},"page":"174-178","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Effect of intraperitoneal magnesium sulfate in the prevention of postoperative pain in daycare laparoscopic cholecystectomy \u2013 A prospective randomized controlled trial"],"prefix":"10.4103","volume":"55","author":[{"given":"Gorle Chaitanya","family":"Sravanthi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Abuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Lal","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish Subbiah","family":"Nagaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anudeep","family":"Jafra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherring","family":"Tandup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash Chand","family":"Kurdia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Dahiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240903","first-page":"139","article-title":"Comparative study of pain level and analgesic requirement after laparoscopic and open cholecystectomy","volume":"4","author":"Kum","year":"1994","journal-title":"Surg Laparosc Endosc"},{"key":"R2-6-20240903","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/110241501750070510","article-title":"Pain and convalescence after laparoscopic cholecystectomy","volume":"167","author":"Bisgaard","year":"2001","journal-title":"Eur J Surg"},{"key":"R3-6-20240903","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1471-0528.1987.tb02365.x","article-title":"Pain after laparoscopy related to posture and ring versus clip sterilization","volume":"94","author":"Dobbs","year":"1987","journal-title":"Br J Obstet Gynaecol"},{"key":"R4-6-20240903","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-6576.1997.tb04664.x","article-title":"Intraperitoneal bupivacaine for analgesia after laparoscopic cholecystectomy","volume":"41","author":"Mraovi\u0107","year":"1997","journal-title":"Acta Anaesthesiol Scand"},{"key":"R5-6-20240903","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bja.2018.06.023","article-title":"Evidence-based management of pain after laparoscopic cholecystectomy: A PROSPECT review update","volume":"121","author":"Barazanchi","year":"2018","journal-title":"Br J Anaesth"},{"key":"R6-6-20240903","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/bja\/aem407","article-title":"Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia","volume":"100","author":"Ryu","year":"2008","journal-title":"Br J Anaesth"},{"key":"R7-6-20240903","first-page":"695","article-title":"Use of magnesium sulfate in anesthesiology","volume":"38","author":"Sirvinskas","year":"2002","journal-title":"Medicina (Kaunas"},{"key":"R8-6-20240903","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/bja\/aep242","article-title":"Magnesium: An emerging drug in anaesthesia","volume":"103","author":"James","year":"2009","journal-title":"Br J Anaesth"},{"key":"R9-6-20240903","first-page":"11","article-title":"Analgesic efficacy of continuous intravenous magnesium infusion as an adjuvant to morphine for postoperative analgesia: A systematic review and meta-analysis","volume":"22","author":"Murphy","year":"2013","journal-title":"Middle East J Anaesthesiol"},{"key":"R10-6-20240903","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.21608\/ejhm.2018.11553","article-title":"Comparative study between intravenous and intraperitoneal magnesium sulphate as adjuvant to general anesthesia for pain management in laparoscopic cholecystectomy","volume":"72","author":"Elfiky","year":"2018","journal-title":"Egypt J Hosp Med"},{"key":"R11-6-20240903","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/1687-7934.156661","article-title":"Effect of intraperitoneal magnesium sulfate on hemodynamic changes and its analgesic and antiemetic effect in laparoscopic cholecystectomy","volume":"8","author":"Ali","year":"2015","journal-title":"Ain Shams J Anaesthesiol"},{"key":"R12-6-20240903","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00000542-199602000-00011","article-title":"Role of magnesium sulfate in postoperative analgesia","volume":"84","author":"Tramer","year":"1996","journal-title":"Anesthesiology"},{"key":"R13-6-20240903","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5055\/jom.2008.0015","article-title":"Effect of magnesium sulfate infusion on sevoflurane consumption, hemodynamics, and perioperative opioid consumption in lumbar disc surgery","volume":"4","author":"Oguzhan","year":"2008","journal-title":"J Opioid Manag"},{"key":"R14-6-20240903","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/EJA.0000000000001348","article-title":"Intravenously injected lidocaine or magnesium improves the quality of early recovery after laparoscopic cholecystectomy: A randomised controlled trial","volume":"38","author":"Lu","year":"2021","journal-title":"Eur J Anaesthesiol"},{"key":"R15-6-20240903","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1399-6576.2009.02165.x","article-title":"Lidocaine versus magnesium: Effect on analgesia after a laparoscopic cholecystectomy","volume":"54","author":"Saadawy","year":"2010","journal-title":"Acta Anaesthesiol Scand"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_827_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:13:58Z","timestamp":1787166838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_827_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_827_22","relation":{},"ISSN":["0253-7613"],"issn-type":[{"value":"0253-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}