{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:40:31Z","timestamp":1793173231200,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Wound-related infections and complications are rare after day care laparoscopic cholecystectomy (LC). They can have a significant adverse impact on the postoperative course after an uneventful elective LC. The use of topical antibiotics over the port site may prevent such complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>\n                      This trial was conducted from January 2018 to June 2019. Two hundred and fifty patients who met the inclusion and exclusion criteria were included in the study. They were randomized into the topical antibiotic group (Group A,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 125) and control group (Group B,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 125). All patients underwent four-port LC. Mupirocin 2% topical antibiotic ointment was applied to all four-port sites in Group A, whereas no topical antibiotic was used in Group B. One dose of prophylactic systemic antibiotics was given to all patients in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The mean age was 43.22 \u00b1 12.7 years in Group A and 43.44 \u00b1 12.5 years in Group B. The comorbidities and the other variables were comparable between the two groups. The port-site infection (PSI) was observed in one patient in Group A and three patients in Group B, which was statistically nonsignificant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.622). The mean time of detection of infection was 4.75 \u00b1 1.7 days. All the infections were superficial surgical site infections. Microbiological swabs culture of the infected wounds yielded no growth of bacteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The PSI after LC is very less. The use of topical antibiotics to prevent PSIs after LC could not be established.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_882_20","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T02:01:33Z","timestamp":1709863293000},"page":"16-19","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Topical antibiotics in the prevention of port-site infection after elective day care laparoscopic cholecystectomy"],"prefix":"10.4103","volume":"56","author":[{"given":"Nipun","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of General Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lileswar","family":"Kaman","sequence":"additional","affiliation":[{"name":"Department of General Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhant","family":"Khare","sequence":"additional","affiliation":[{"name":"Department of General Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Department of General Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of General Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttam Kumar","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of General Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"R1-20260504","doi-asserted-by":"crossref","first-page":"864","DOI":"10.12998\/wjcc.v3.i10.864","article-title":"Port site infection in laparoscopic surgery: A review of its management","volume":"3","author":"Sasmal","year":"2015","journal-title":"World J Clin Cases"},{"key":"R2-20260504","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.SLA.0000055221.50062.7A","article-title":"Does using a laparoscopic approach to cholecystectomy decrease the risk of surgical site infection?","volume":"237","author":"Richards","year":"2003","journal-title":"Ann Surg"},{"key":"R3-20260504","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/0972-9941.110964","article-title":"Analysis of laparoscopic port site complications: A descriptive study","volume":"9","author":"Karthik","year":"2013","journal-title":"J Minim Access Surg"},{"key":"R4-20260504","first-page":"197","article-title":"Frequency and prevention of laparoscopic port site infection","volume":"24","author":"Taj","year":"2012","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"R5-20260504","first-page":"397","article-title":"Surgical infections after laparoscopic cholecystectomy: Ceftriaxone versus ceftazidime antibiotic prophylaxis. 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