{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:39Z","timestamp":1787772459388,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n \n The current study aimed to estimate phytochemical screening,\n in vitro<\/jats:italic>\n antioxidant activity, and gastroprotective activity of\n Sesamum indicum<\/jats:italic>\n Linn ethanolic extract.\n <\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n The current study was held out by ulceration induced by pylorus ligation and indomethacin-induced ulcer screening models in Wister albino rats. The screening of antiulcer activity of ethanolic extract of\n S. indicum<\/jats:italic>\n leaves (EESIL) at the different amounts (100, 200, and 400 mg\/kg; per orally for 7 days) was compared with omeprazole as a usual antiulcer drug. Additional parameters such as gastric content, pH, total acidity, pepsin activity ulcer score, free acidity, ulcer index (UI), % inhibition of ulcers, mean mucin, pepsin content, and total protein content were observed.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n In the pylorus ligation model, the pepsin activity free acidity, pepsin content, UI, total acidity, ulcer score, total protein content, and percentage ulcer inhibition were considerably decreased (\n P<\/jats:italic>\n < 0.05 and\n P<\/jats:italic>\n < 0.01), and mean mucin and gastric content pH extensively elevated (\n P<\/jats:italic>\n < 0.05 and\n P<\/jats:italic>\n < 0.01) in EESIL tested groups in the comparison of the control group. Doses (100, 200, and 400 mg\/kg p.o.) of EESIL showed dose-reliant gastro protective outcomes, a considerable (\n P<\/jats:italic>\n < 0.05 and\n P<\/jats:italic>\n < 0.01) decrease in gastric parameters as UI and ulcer score and induction in gastric pH and percentage inhibition of ulcer compared with the control group.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Antioxidant, anti-Ulcer, EESIL, and EESIL show antioxidant activity at different concentration. The fallout of the study indicated that the EESIL had improved antiulcer potential due to the decrease in offensive factors and increase in defensive factors.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijp.ijp_98_22","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:47:00Z","timestamp":1716479220000},"page":"423-430","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of mechanism(s) of action underlying the antioxidant and antiulcer activity of Sesamum indicum leaves extract in experimental rats"],"prefix":"10.4103","volume":"54","author":[{"family":"Shivam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phool","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Sachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240903","doi-asserted-by":"crossref","first-page":"662","DOI":"10.2174\/1389557520666191227151939","article-title":"Medicinal plants in the treatment of peptic ulcer disease: A review","volume":"20","author":"Ardalani","year":"2020","journal-title":"Mini Rev Med Chem"},{"key":"R2-5-20240903","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1055\/a-1107-9370","article-title":"Harnessing the phytotherapeutic treasure troves of the ancient medicinal plant Azadirachta indica (Neem) and associated endophytic microorganisms","volume":"86","author":"Kharwar","year":"2020","journal-title":"Planta Med"},{"key":"R3-5-20240903","first-page":"1225","article-title":"The genus Cuscuta (Convolvolaceac): An updated review on indigenous uses, phytochemistry, and pharmacology","volume":"22","author":"Noureen","year":"2019","journal-title":"Iran J Basic Med Sci"},{"key":"R4-5-20240903","first-page":"65","article-title":"Curcuma longa and curcumin: A review article","volume":"55","author":"Akram","year":"2010","journal-title":"Rom J Biol Plant Biol"},{"key":"R5-5-20240903","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3389\/fpls.2017.01154","article-title":"The emerging oilseed crop Sesamum indicum enters the \u201cOmics\u201d era","volume":"8","author":"Dossa","year":"2017","journal-title":"Front Plant Sci"},{"key":"R6-5-20240903","first-page":"47","article-title":"Alhagi pseudalhagi: A review of its phyto-chemistry, pharmacology, folklore claims and Ayurvedic studies","volume":"2","author":"Srivastava","year":"2014","journal-title":"Int J Herb Med"},{"key":"R7-5-20240903","doi-asserted-by":"crossref","first-page":"S359","DOI":"10.12980\/APJTB.4.2014C1030","article-title":"Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. for in vitro antioxidant activities","volume":"4","author":"Senguttuvan","year":"2014","journal-title":"Asian Pac J Trop Biomed"},{"key":"R8-5-20240903","first-page":"268","article-title":"In vitro antimicrobial activity nutritional profile of medicinal plant of Garhwal, Himalaya","volume":"3","author":"Saklani","year":"2012","journal-title":"Int J Pharm Sci Res"},{"key":"R9-5-20240903","doi-asserted-by":"crossref","first-page":"112393","DOI":"10.1016\/j.phytochem.2020.112393","article-title":"Antioxidant activity and mechanism of dihydrochalcone C-glycosides: Effects of C-glycosylation and hydroxyl groups","volume":"179","author":"Xue","year":"2020","journal-title":"Phytochemistry"},{"key":"R10-5-20240903","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.lwt.2011.11.009","article-title":"Total phenolic and total flavonoid content, antioxidant activity and sensory evaluation of pseudocereal breads","volume":"46","author":"Chlopicka","year":"2012","journal-title":"LWT Food Sci Technol"},{"key":"R11-5-20240903","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2174\/1570163815666180629164332","article-title":"Oral acute and repeated-doses toxicity study of valepotriates from Valeriana glechomifolia (Meyer) in Mice","volume":"16","author":"de Almeida","year":"2019","journal-title":"Curr Drug Discov Technol"},{"key":"R12-5-20240903","first-page":"113","article-title":"Gastroprotective efficacy of folic acid and omeprazole in indomethacin-induced gastropathy in rats","volume":"5","author":"Murjan","year":"2013","journal-title":"Int J Pharm Phytochem Res"},{"key":"R13-5-20240903","doi-asserted-by":"crossref","first-page":"2809270","DOI":"10.1155\/2020\/2809270","article-title":"Evaluation of antiulcer activity of 80% methanol extract and solvent fractions of the root of Croton macrostachyus Hocsht: Ex Del. 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