{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:30:06Z","timestamp":1787841006018,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background:<\/jats:title>\n HTLV-1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) and adult T-cell leukemia\/lymphoma (ATLL) are both severe diseases caused by Human T-lymphotropic virus type 1 (HTLV-1) infection, while about 95% of infected cases remain asymptomatic. Genes that play a role in ATLL development are assumed to be dissimilar from the ones that are crucial factors for HAM\/TSP occurrence.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n \n The expression of six genes including\n BRCA1<\/jats:italic>\n ,\n CHUCK<\/jats:italic>\n ,\n ESR1<\/jats:italic>\n ,\n NFKBIA<\/jats:italic>\n ,\n PIK3R1<\/jats:italic>\n , and\n PPARG<\/jats:italic>\n were assessed in two groups of HAM\/TSP and ATLL patients. Materials and Methods: cDNA was synthesized from purified RNA, and RT-qPCR was conducted to assess the expression of the genes in two groups. Any possible correlation among the genes\u2019 expression was also calculated. Results:\n BRCA1<\/jats:italic>\n and\n CHUCK<\/jats:italic>\n expressions were higher in HAM\/TSP patients in comparison with ATLL patients. However,\n ESR1<\/jats:italic>\n ,\n NFKBIA<\/jats:italic>\n ,\n PIK3R1<\/jats:italic>\n , and PPARG are more expressed in ATLL cases than HAM\/TSP. A significant positive correlation was observed between\n BRCA1<\/jats:italic>\n and\n NFKBIA<\/jats:italic>\n in HAM\/TSP group. In addition, a significant negative correlation between\n PIK3R1<\/jats:italic>\n and\n PPARG<\/jats:italic>\n in HAM\/TSP and between\n ESR1<\/jats:italic>\n and\n NFKBIA<\/jats:italic>\n in the ATLL group was obtained.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n HAM\/TSP or ATLL stem from a disturbance in the expression of diverse genes and these dissimilarities should be discovered to reach a better understanding of disease treatment as well as screening and assessing the asymptomatic carriers\u2019 condition for developing severe disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_1007_22","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T06:00:42Z","timestamp":1717740042000},"page":"824-828","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Higher expression of BRCA1, and CHUK and lower expression of NFKBIA, ESR1, PIK3R1, and PPARG in HAM\/TSP compared to ATLL, a diverse pathological consequence"],"prefix":"10.4103","volume":"67","author":[{"given":"Sahar","family":"Yaslianifard","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monireh","family":"Movahedi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Yaslianifard","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran"},{"name":"Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, 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