{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:01Z","timestamp":1787840521402,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sarcomas arising in a parotid gland is an uncommon occurrence and a sarcomatous transformation in a recurring pleomorphic adenoma is even rare. Diagnosis of salivary gland tumors has proven to be challenging. Pleomorphic adenomas (PA) are the most commonly diagnosed tumors of the salivary gland and a malignant transformation in preexisting or recurring ones is even thinner on the ground. Malignant transformations in a pleomorphic adenoma can occur in carcinomas, carcinosarcomas, or sarcomas. We are sharing an interesting case of a 68-year-old male with a parotid region swelling with a history of recurring pleomorphic adenomas. There was seen a sarcomatous transformation in pleomorphic adenoma which was proven on IHC. A correlation among cytopathology, histopathology, and previous clinical history is been tendered in our case report.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_1008_23","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T05:00:10Z","timestamp":1749445210000},"page":"836-838","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Sarcoma, ex pleomorphic adenoma of parotid gland: A rare entity"],"prefix":"10.4103","volume":"68","author":[{"given":"Mehar","family":"Ghuman","sequence":"first","affiliation":[{"name":"Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"R1-20251208","first-page":"12","article-title":"Pleomorphic adenoma","volume":"153","author":"Wasylik","year":"2001","journal-title":"J La State Med Soc"},{"key":"R2-20251208","first-page":"9795785","article-title":"Leiomyosarcoma ex pleomorphic adenoma of the parotid gland: A case report and literature review","author":"Coulter","year":"2016","journal-title":"Case Rep Otolaryngol 2016"},{"key":"R3-20251208","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1001\/archotol.1991.01870150070009","article-title":"Primary sarcomas of the major salivary glands","volume":"117","author":"Luna","year":"1991","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"R4-20251208","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/1097-0142(19860915)58:6<1305::AID-CNCR2820580621>3.0.CO;2-K","article-title":"Sarcomas and sarcomatoid neoplasms of the major salivary gland regions. A clinicopathologic and immunohistochemical study of 67 cases and review of the literature","volume":"58","author":"Auclair","year":"1986","journal-title":"Cancer"},{"key":"R5-20251208","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1016\/j.tripleo.2006.12.073","article-title":"Sarcoma ex-pleomorphic adenoma: A case report of a unique entity","volume":"103","author":"Said-Al-Naief","year":"2007","journal-title":"Oral Me, Oral Pathol, Oral Radiol, Endod"},{"key":"R6-20251208","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/1097-0142(197811)42:5<2407::AID-CNCR2820420542>3.0.CO;2-Y","article-title":"Metastasizing pleomorphic adenoma of the salivary gland","volume":"42","author":"Chen","year":"1978","journal-title":"Cancer"},{"key":"R7-20251208","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0344-0338(11)80273-6","article-title":"Metastasizing pleomorphic adenoma with myoepithelial cell predominance","volume":"186","author":"Cresson","year":"1990","journal-title":"Pathol Res Pract"},{"key":"R8-20251208","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/1097-0142(19810701)48:1<113::AID-CNCR2820480122>3.0.CO;2-F","article-title":"Histopathologic studies on carcinoma in pleomorphic adenoma of the parotid gland","volume":"48","author":"Nagao","year":"1981","journal-title":"Cancer"},{"key":"R9-20251208","first-page":"279","article-title":"Malignant mixed tumors of the salivary glands: A review","volume":"28","author":"Gnepp","year":"1993","journal-title":"Pathol Annu"},{"key":"R10-20251208","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.4314\/ahs.v19i4.50","article-title":"Carcinoma ex pleomorphic adenoma: A case report and review of literature","volume":"19","author":"Khanna","year":"2019","journal-title":"Afr Health Sci"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_1008_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:26Z","timestamp":1787837066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_1008_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_1008_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"2023-12-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}