{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:08:20Z","timestamp":1793329700134,"version":"4.5.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Several defining molecular alterations have recently been identified underlying high-grade endometrial stromal sarcomas, such as\n YWHAE: NUTM2A\/B<\/jats:italic>\n fusions,\n ZC3H7B: BCOR<\/jats:italic>\n fusions, and\n BCOR<\/jats:italic>\n internal tandem duplication (ITD). BCOR is a useful immunohistochemical marker for identifying these tumors. A 37-year-old lady was presented with a 10-cm-sized tumor in the pouch of Douglas, involving the vaginal vault, bilateral adnexa, and peritoneum. A 53-year-old lady with a prior hysterectomy was presented with a 12-cm-sized tumor in the vault with abdominal deposits. Histopathological examination of both tumors revealed atypical cells comprising oval to spindle-shaped nuclei, a variable amount of myxoid stroma, and mitotic figures exceeding 10\/10 high power fields. Immunohistochemically, the former tumor was diffusely positive for CD10, and the second tumor displayed patchy staining. Both tumors were positive for BCOR. Estrogen receptor (ER) showed variable staining in both tumors. By fluorescence\n in-situ<\/jats:italic>\n hybridization (FISH), both tumors lacked\n YWHAE<\/jats:italic>\n gene rearrangement. Both tumors had an aggressive clinical course, including extensive involvement This constitutes the first report of BCOR-positive high-grade sarcomas involving the female genital tract from our subcontinent. BCOR is a useful immunostain for identifying these relatively aggressive tumors. The differential diagnoses and the prognosis of these ultra-rare tumors are discussed herewith.\n <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_1021_22","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T02:44:52Z","timestamp":1690253092000},"page":"829-833","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["High-grade endometrial stromal sarcoma displaying immunohistochemical expression of BCOR\u2014A report of two cases of a novel tumor entity"],"prefix":"10.4103","volume":"66","author":[{"given":"Varsha","family":"Wagh","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology, Tata Memorial Hospital, Mumbai, Homi Bhabha National Institute (HBNI) University, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Tata Memorial Hospital, Mumbai, Homi Bhabha National Institute (HBNI) University, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Homi Bhabha National Institute (HBNI) University, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology (Gynecology Disease Management Group), Tata Memorial Hospital, Mumbai, Homi Bhabha National Institute (HBNI) University, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedar K.","family":"Deodhar","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Tata Memorial Hospital, Mumbai, Homi Bhabha National Institute (HBNI) University, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Rekhi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Tata Memorial Hospital, Mumbai, Homi Bhabha National Institute (HBNI) University, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"issue":"Suppl 2","key":"R2-20240829","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ijgo.12613","article-title":"Uterine sarcomas","volume":"143","author":"Mbatani","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/modpathol.2017.162","article-title":"ZC3H7B-BCOR high-grade endometrial stromal sarcomas: A report of 17 cases of a newly defined entity","volume":"31","author":"Lewis","year":"2018","journal-title":"Mod 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morphology","volume":"30","author":"Chiang","year":"2017","journal-title":"Mod Pathol"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000493322","article-title":"A pan-cancer landscape analysis reveals a subset of endometrial stromal and pediatric tumors defined by internal tandem duplications of BCOR","volume":"96","author":"Juckett","year":"2019","journal-title":"Oncology"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1097\/PAS.0000000000000697","article-title":"BCOR Overexpression is a highly sensitive marker in round cell sarcomas with BCOR genetic abnormalities","volume":"40","author":"Kao","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ygyno.2010.12.363","article-title":"Incidence of lymph node and adnexal metastasis in endometrial stromal sarcoma","volume":"121","author":"dos Santos","year":"2011","journal-title":"Gynecol Oncol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_1021_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:10:40Z","timestamp":1787771440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_1021_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,26]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_1021_22","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,26]]},"assertion":[{"value":"2022-12-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}