{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:21:34Z","timestamp":1793366494900,"version":"4.5.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"\n Background:<\/jats:title>\n Tumor budding (TB) is a morphological finding believed to play an important role in determining the prognosis in many cancers.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n Our aim is to evaluate the prognostic importance of TB in endometrial carcinomas.<\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n Two-hundred-eleven endometrial cancers were obtained from 2008 to 2015 that were comprised of those having undergone surgical staging with a hysterectomy and at least 5 years followed up.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n All hematoxylin and eosin stained slides were reevaluated for the status of TB.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n Nonparametric tests, the Kaplan\u2013Meier method, the Log-rank test, and Cox proportional hazard regression were used.<\/jats:p>\n <\/jats:sec>\n \n Results and Conclusion:<\/jats:title>\n \n TB was found to correlated with larger diameter (\n P<\/jats:italic>\n = 0.000), nonendometrioid (\n P<\/jats:italic>\n = 0.038), mixed cell types (\n P<\/jats:italic>\n = 0.005), higher grade (\n P<\/jats:italic>\n = 0.000), deeper invasion of the myometrium (\n P<\/jats:italic>\n = 0.000), cervical stromal invasion (\n P<\/jats:italic>\n = 0.000), advanced pT (\n P<\/jats:italic>\n = 0.011), lymph node involvement (\n P<\/jats:italic>\n = 0.000), lymphovascular invasion (\n P<\/jats:italic>\n = 0.000), and advanced stage (\n P<\/jats:italic>\n = 0.000). The presence of TB worsens the 5-year overall survival (OS) (\n P<\/jats:italic>\n = 0.0001). In cases such as grade 1, pT1, or stage 1 endometrial carcinomas, the presence of TB decreases the OS rate (\n P<\/jats:italic>\n = 0.00017,\n P<\/jats:italic>\n = 0.0016,\n P<\/jats:italic>\n < 0.0001). Our result suggested that the presence of TB adversely affects the prognosis. It was concluded that TB could be a valuable prognostic parameter.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_109_21","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T15:35:46Z","timestamp":1724945746000},"page":"851-855","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Tumor budding is a valuable prognostic parameter in endometrial carcinomas"],"prefix":"10.4103","volume":"65","author":[{"given":"Irfan","family":"Ocal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Guzelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20240829","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"R2-19-20240829","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0090-8258(83)90111-7","article-title":"Two pathogenetic types of endometrial carcinoma","volume":"15","author":"Bokhman","year":"1983","journal-title":"Gynecol Oncol"},{"key":"R3-19-20240829","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s12253-018-0554-x","article-title":"Tumor budding is a valuable diagnostic parameter in prediction of disease progression of endometrial endometrioid carcinoma","volume":"25","author":"Park","year":"2019","journal-title":"Pathol Oncol Res"},{"key":"R5-19-20240829","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ygyno.2011.12.433","article-title":"Tumor budding and E-Cadherin expression in endometrial carcinoma: Are they prognostic factors in endometrial cancer?","volume":"125","author":"Koyuncuoglu","year":"2012","journal-title":"Gynecol Oncol"},{"key":"R6-19-20240829","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/1097-0142(19890201)63:3<539::AID-CNCR2820630323>3.0.CO;2-S","article-title":"An index for estimating the probability of lymph node metastasis in rectal cancers. 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