{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:33:47Z","timestamp":1787772827848,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Erythrophagocytosis (EP) is extremely rare in de novo acute lymphoblastic leukemia (ALL). We document a rare case, which in addition, showed extensive blast vacuolization. A detailed literature review has also been incorporated with the aim of unraveling the prognostic import of our morphological observations if any. A five-year-old male presented with fever and progressive pallor for 1 month. He had hepatosplenomegaly and bicytopenia. Peripheral smear examination showed 43% blasts. Nuclear and cytoplasmic vacuolations were seen in 75% blasts and EP in 4% blasts. The blasts showed block positivity on periodic acid-Schiff (PAS) stain. Marrow aspirate smears showed 58% blasts displaying a similar morphology. Flow cytometry showed features of a common acute lymphoblastic leukemia antigen (CALLA) positive B-cell ALL with aberrant, dim CD 33 expression in 53.4% of the gated blasts. Fluorescence\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      hybridization showed translocation (12; 21) (p13;q22). The patient responded well to standard induction therapy. To conclude, EP is rarely seen in de novo ALL and is associated with a favorable translocation, t(12;21).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_1154_20","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T14:46:00Z","timestamp":1724942760000},"page":"191-194","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Erythrophagocytosis in a patient with B-cell acute lymphoblastic leukemia with t(12;21) (p13.2; q22.1); ETV6-RUNX1"],"prefix":"10.4103","volume":"65","author":[{"given":"Sunita","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijan","family":"Srivastav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piali","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-39-20240829","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/0022-3859.201413","article-title":"Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t (8;16)","volume":"63","author":"Gupta","year":"2017","journal-title":"J Postgrad Med"},{"key":"R2-39-20240829","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ccr3.120","article-title":"De novo acute myeloid leukemia with monocytoid blasts and erythrophagocytosis","volume":"2","author":"Blieden","year":"2014","journal-title":"Clin Case Rep"},{"key":"R3-39-20240829","first-page":"186","article-title":"Hemophagocytosis by leukemic blasts in B lymphoblastic leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1): A case report","volume":"43","author":"Park","year":"2013","journal-title":"Ann Clin Lab Sci"},{"key":"R4-39-20240829","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1182\/blood-2018-01-830513","article-title":"Frequent erythrophagocytosis by leukemic blasts in B-cell acute lymphoblastic leukemia","volume":"131","author":"Olaiya","year":"2018","journal-title":"Blood"},{"key":"R5-39-20240829","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/ajcp\/92.5.696","article-title":"Acute myeloblastic leukemia with extensive erythrophagocytosis mimicking malignant histiocytosis","volume":"92","author":"Hassinger","year":"1989","journal-title":"Am J Clin Pathol"},{"key":"R6-39-20240829","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1136\/jclinpath-2016-203915","article-title":"Erythrophagocytosis in T-cell type acute lymphoblastic leukaemia with near-tetraploidy","volume":"69","author":"Watanabe","year":"2016","journal-title":"J Clin Pathol"},{"key":"R7-39-20240829","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0025-6196(12)62056-4","article-title":"Erythrophagocytic acute lymphocytic leukemia with B-cell markers and with a 20q- chromosome abnormality","volume":"59","author":"Colon-Otero","year":"1984","journal-title":"Mayo Clin Proc"},{"key":"R8-39-20240829","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2141.1988.tb02461.x","article-title":"Blast cell vacuoles in childhood lymphoblastic leukaemia","volume":"70","author":"Lilleyman","year":"1988","journal-title":"Br J Haematol"},{"key":"R9-39-20240829","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/mpo.2950140104","article-title":"Phagocytic activity and expression of myeloid-associated cell surface antigens by blast cells in acute lymphoblastic leukemia","volume":"14","author":"Pui","year":"1986","journal-title":"Med Pediatr Oncol"},{"key":"R10-39-20240829","first-page":"57","article-title":"A case of erythrophagocytosis in a T-cell lymphoblastic lymphoma","volume":"31","author":"Kim","year":"1990","journal-title":"Seoul J Med"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_1154_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:13:57Z","timestamp":1787771637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_1154_20"}},"subtitle":["Case report and review of the literature"],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_1154_20","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}