{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:38Z","timestamp":1786653698906,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Because of its rarity, the diagnosis of optic nerve medulloepithelioma poses a real diagnostic challenge. Medulloepithelioma is a congenital tumor that derives from the primitive medullary epithelium present in the neural tube and the optic vesicle. Its classical location is the ciliary body. Cases of retinal or optic nerve locations have been rarely reported in the literature. Only 11 cases have been published in the English literature. Herein, we report the case of a 2-year-old boy who underwent enucleation of the right eye for a presumed diagnosis of right-eye retinoblastoma, based on the presence of leukocoria on ophthalmological examination. Pathological examination showed an optic nerve medulloepithelioma. A review of the literature is also discussed in our work.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_116_22","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T06:22:12Z","timestamp":1677219732000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Pigmented medulloepithelioma of the optic nerve: A challenging diagnostic entity"],"prefix":"10.4103","author":[{"given":"Tiabi","family":"El Mehdi","sequence":"first","affiliation":[{"name":"Department of Pathology, Mohammed VI University Hospital, Oujda, Morocco"},{"name":"Faculty of Medicine and Pharmacy of Oujda, Mohammed First University of Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chariba","family":"Siham","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, Mohammed VI University Hospital, Oujda, Morocco"},{"name":"Faculty of Medicine and Pharmacy of Oujda, Mohammed First University of Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaoui","family":"Imane","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mohammed VI University Hospital, Oujda, Morocco"},{"name":"Faculty of Medicine and Pharmacy of Oujda, Mohammed First University of Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benajiba","family":"Noufissa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mohammed VI University Hospital, Oujda, Morocco"},{"name":"Faculty of Medicine and Pharmacy of Oujda, Mohammed First University of Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennani","family":"Amal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mohammed VI University Hospital, Oujda, Morocco"},{"name":"Faculty of Medicine and Pharmacy of Oujda, Mohammed First University of Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"R1-20240213","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/sj.eye.6701592","article-title":"Primary tumours of the optic nerve and its sheath","volume":"18","author":"Miller","year":"2004","journal-title":"Eye"},{"key":"R2-20240213","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1440-1789.2008.00886.x","article-title":"Malignant non-teratoid medulloepithelioma of ciliary body with retinoblastic differentiation:A case report and review of literature","volume":"28","author":"Al-Salam","year":"2008","journal-title":"Neuropathology"},{"key":"R3-20240213","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1148\/rg.274075014","article-title":"From the archives of the AFIP:Pediatric orbit tumors and tumorlike lesions:Neuroepithelial lesions of the ocular globe and optic nerve","volume":"27","author":"Chung","year":"2007","journal-title":"Radiographics"},{"key":"R4-20240213","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.humpath.2011.02.020","article-title":"Medulloepithelioma of the optic disc","volume":"42","author":"Corr\u00eaa","year":"2011","journal-title":"Hum Pathol"},{"key":"R5-20240213","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0002-9394(57)91946-3","article-title":"Medullo-epithelioma (dictyoma) of the optic nerve","volume":"44","author":"Reese","year":"1957","journal-title":"Am J Ophthalmol"},{"key":"R6-20240213","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1442-9071.2006.01321.x","article-title":"Ciliary body medulloepithelioma:Clinical, ultrasound biomicroscopic and histopathologic correlation","volume":"34","author":"Ayres","year":"2006","journal-title":"Clin Experiment Ophthalmol"},{"key":"R7-20240213","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.survophthal.2008.08.022","article-title":"Primary optic nerve sheath meningioma in children","volume":"53","author":"Harold Lee","year":"2008","journal-title":"Surv Ophthalmol"},{"key":"R8-20240213","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.nic.2005.02.008","article-title":"Medulloepithelioma of the ciliary body and optic nerve:Clinicopathologic, CT, and MR imaging features","volume":"15","author":"Vajaranant","year":"2005","journal-title":"Neuroimaging Clin N Am"},{"key":"R9-20240213","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3928\/0191-3913-20040101-11","article-title":"Medulloepithelioma of the optic nerve","volume":"41","author":"Chavez","year":"2004","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"R10-20240213","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0002-9394(74)90461-9","article-title":"Primary malignant medulloepithelioma of the retinal stalk","volume":"77","author":"Mullaney","year":"1974","journal-title":"Am J Ophthalmol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_116_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:08Z","timestamp":1786650068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_116_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,24]]},"references-count":10,"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_116_22","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,24]]},"assertion":[{"value":"2022-01-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}