{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:28:14Z","timestamp":1786728494380,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mucinous carcinomas arising within an ovarian dermoid tumor are rare. Most of the cases reported in the literature show morphological features resembling an appendiceal mucinous neoplasm. They exhibit CK7-\/CK20+ immunophenotype similar to carcinomas of the lower gastrointestinal tract. In this report, we have described a case of a well-differentiated mucinous carcinoma arising within a mature cystic teratoma. The mucinous carcinoma showed a spectrum of morphological patterns, including cystadenoma-like areas, proliferative\/borderline areas, villous adenoma-like areas, and areas of invasive carcinoma. In addition, our case showed some unusual findings, namely, diffuse CK7 positivity, associated pseudomyxoma peritonei, and metastasis to lungs. These features were not demonstrated in any of the previously reported cases. Our case shows that the teratomatous mucinous neoplasm of the ovary may show CK7+\/CK20+\/CDX2 + immunoprofile making it immunohistochemically indistinguishable from a primary ovarian mucinous neoplasm or a metastatic mucinous carcinoma of the lower gastrointestinal tract.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_1255_21","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T03:00:14Z","timestamp":1708052414000},"page":"183-189","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["CK7+\/CK20+\/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei"],"prefix":"10.4103","volume":"68","author":[{"given":"Amit K.","family":"Adhya","sequence":"first","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhitesh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillip K.","family":"Muduly","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Radiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"R1-20250411","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/00000478-200305000-00008","article-title":"Mucinous tumors arising in ovarian mature cystic teratomas:Relationship to the clinical syndrome of pseudomyxoma peritonei","volume":"27","author":"Ronnett","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"R2-20250411","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/030089160409000517","article-title":"An ovarian mucinous adenocarcinoma arising from mature cystic teratoma associated with respiratory type tissue:A case report","volume":"90","author":"Cobellis","year":"2004","journal-title":"Tumori"},{"key":"R3-20250411","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/gyno.1998.5123","article-title":"Adenocarcinoma arising from the gastrointestinal epithelium in benign cystic teratoma of the ovary","volume":"70","author":"Fishman","year":"1998","journal-title":"Gynecol Oncol"},{"key":"R4-20250411","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1080\/00313020601024078","article-title":"Ovarian mucinous tumour arising in mature cystic teratoma and associated with pseudomyxoma peritonei:Report of two cases and comparison with ovarian involvement by low-grade appendiceal mucinous tumour","volume":"38","author":"Stewart","year":"2006","journal-title":"Pathology"},{"key":"R5-20250411","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.2147\/CMAR.S264474","article-title":"Clinicopathological characteristics of pseudomyxoma peritonei originated from ovaries","volume":"12","author":"Yan","year":"2020","journal-title":"Cancer Manag Res"},{"key":"R6-20250411","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1159\/000447258","article-title":"Advanced mucinous adenocarcinoma arising from a mature cystic teratoma:A case report and literature review","volume":"9","author":"Miyasaka","year":"2016","journal-title":"Case Rep Oncol"},{"key":"R7-20250411","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3802\/jgo.2008.19.4.275","article-title":"An ovarian mucinous cystadenocarcinoma arising from mature cystic teratoma with para-aortic lymph node metastasis:A case report","volume":"19","author":"Park","year":"2008","journal-title":"J Gynecol Oncol"},{"key":"R8-20250411","first-page":"7894581","article-title":"Intestinal adenocarcinoma arising from a mature cystic teratoma","volume":"2019","author":"Wan","year":"2019","journal-title":"Case Rep Pathol"},{"key":"R9-20250411","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/PAS.0b013e31815b486d","article-title":"Ovarian mature teratomas with mucinous epithelial neoplasms:Morphologic heterogeneity and association with pseudomyxoma peritonei","volume":"32","author":"McKenney","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"R10-20250411","first-page":"e69","article-title":"[Mucinous tumour in a mature ovarian teratoma:An unusual presentation of pseudomyxoma peritonei","volume":"93","author":"Motos","year":"2015","journal-title":"Cir Esp"},{"key":"R11-20250411","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1757-2215-5-41","article-title":"Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary:A rare case report and review of the literature","volume":"5","author":"Takai","year":"2012","journal-title":"J Ovarian Res"},{"key":"R12-20250411","first-page":"465","article-title":"Mature cystic teratoma of the ovary associated with complete colonic wall and mucinous cystadenoma","volume":"33","author":"Tang","year":"2003","journal-title":"Ann Clin Lab Sci"},{"key":"R13-20250411","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/PGP.0000000000000110","article-title":"Mature cystic teratoma of ovary with mucinous epithelial neoplasm and malignant mural nodule:A case report and review of the literature","volume":"34","author":"Vernea","year":"2015","journal-title":"Int J Gynecol Pathol"},{"key":"R14-20250411","first-page":"649521","article-title":"Mucinous cystadenoma arising in a mature cystic teratoma in a 25-year-old patient","volume":"2014","author":"Pintea","year":"2014","journal-title":"Case Rep Obstet Gynecol"},{"key":"R15-20250411","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/PAS.0b013e31802efb45","article-title":"Ovarian mucinous tumors associated with mature cystic teratomas:Morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary","volume":"31","author":"Vang","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"R16-20250411","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13000-021-01079-2","article-title":"Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree:A review of current problematics","volume":"16","author":"Dundr","year":"2021","journal-title":"Diagn Pathol"},{"key":"R17-20250411","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2559.2006.02512.x","article-title":"CDX-2 expression in pseudomyxoma peritonei:A clinicopathological study of 42 cases","volume":"49","author":"Nonaka","year":"2006","journal-title":"Histopathology"},{"key":"R18-20250411","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/01.pgp.0000101141.31270.a0","article-title":"The value of Cdx2 immunostaining in differentiating primary ovarian carcinomas from colonic carcinomas metastatic to the ovaries","volume":"23","author":"Groisman","year":"2004","journal-title":"Int J Gynecol Pathol"},{"key":"R19-20250411","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00129039-200406000-00005","article-title":"Utility of CDX-2 in distinguishing between primary and secondary (intestinal) mucinous ovarian carcinoma:An immunohistochemical comparison of 43 cases","volume":"12","author":"Raspollini","year":"2004","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"R20-20250411","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/PAS.0000000000000535","article-title":"A consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia:The results of the peritoneal surface oncology group international (PSOGI) modified Delphi process","volume":"40","author":"Carr","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"R21-20250411","first-page":"113","article-title":"Low Grade Appendiceal Muci-nous Neoplasm with Pseudomyxoma Peritonei:An Enigma for Pathologist","volume":"2014","author":"Qadri","journal-title":"Euroasian J Hepato-Gastroenterol"},{"key":"R22-20250411","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1097\/00000478-200011000-00001","article-title":"Mucinous tumors of the ovary:A clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'","volume":"24","author":"Lee","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"R23-20250411","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1136\/jcp.2004.025148","article-title":"Pseudomyxoma peritonei:Unusual origin from an ovarian mature cystic teratoma","volume":"58","author":"Pranesh","year":"2005","journal-title":"J Clin Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_1255_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:47Z","timestamp":1786724867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_1255_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,14]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_1255_21","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,14]]},"assertion":[{"value":"2021-12-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}