{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:54Z","timestamp":1787840334226,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    B-ALL, a genetically heterogeneous disease, is predominantly characterized by translocations leading to the formation of chimeric fusion proteins, which are known leukemia drivers. These driver fusions along with some driver mutations form an important basis for 11 distinct and mutually exclusive genetic subgroups by WHO. This classification besides providing important insights into distinct disease biology also provides important prognostic and therapeutic guidance. Coexistence of leukemia fusion drivers in B-ALL is a rare event and literature evidence with respect to clinical outcome of such patients remains elusive. We report a rare case of pediatric B-ALL with coexistence of\n                    <jats:italic toggle=\"yes\">TCF3<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">IGH<\/jats:italic>\n                    gene rearrangement. The patient responded well to induction chemotherapy with good response to steroids. Minimal residual disease was negative postinduction. The patient is presently under follow-up and remains in remission ~28 months post diagnosis. This case adds to our understanding of such rare phenomenon and enlighten us the response to chemotherapy in such circumstances.\n                  <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_126_24","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T17:00:10Z","timestamp":1755536410000},"page":"874-876","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Novel case of coexisting TCF3 and IGH gene rearrangement in pediatric B-cell acute lymphoblastic leukemia: Favorable response to steroids and standard chemotherapy"],"prefix":"10.4103","volume":"68","author":[{"given":"Anurag","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana, India"},{"name":"Department of Cytogenetics and Molecular Pathology, AMPATH, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Verma","sequence":"additional","affiliation":[{"name":"King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"R1-20251208","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"R2-20251208","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/ijlh.14072","article-title":"TCF3 gene rearrangements in pediatric B-cell acute lymphoblastic leukemia-A single center experience","volume":"45","author":"Zerkalenkova","year":"2023","journal-title":"Int J Lab Hematol"},{"key":"R3-20251208","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41408-019-0239-z","article-title":"Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia\/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3\/TEF gene fusion","volume":"9","author":"Rowsey","year":"2019","journal-title":"Blood Cancer J"},{"key":"R6-20251208","doi-asserted-by":"crossref","first-page":"11711","DOI":"10.1073\/pnas.1814397115","article-title":"Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1223 cases","volume":"115","author":"Li","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"R7-20251208","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cancergen.2013.04.004","article-title":"Chromosomal translocations involving the IGH@locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature","volume":"206","author":"Chapiro","year":"2013","journal-title":"Cancer Genet"},{"key":"R9-20251208","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1182\/bloodadvances.2016000463","article-title":"BCR-ABL1 gene rearrangement as a subclonal change in ETV6-RUNX1-positive B-cell acute lymphoblastic leukemia","volume":"1","author":"Dun","year":"2016","journal-title":"Blood Adv"},{"key":"R10-20251208","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3324\/haematol.2014.103820","article-title":"IGH@translocations co-exist with other primary rearrangements in B-cell precursor acute lymphoblastic leukemia","volume":"99","author":"Jeffries","year":"2014","journal-title":"Haematologica"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_126_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:20:35Z","timestamp":1787836835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_126_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_126_24","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"assertion":[{"value":"2024-02-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}