{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:19:27Z","timestamp":1787775567019,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ocular surface squamous neoplasia (OSSN) comprises neoplasm arising from the ocular surface, which includes conjunctiva, cornea, and limbus and ranges from mild dysplasia to invasive squamous cell carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The aim of this work was to study the spectrum of OSSN based on histopathological analysis. Materials and<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective cross-sectional study comprising 776 histopathologically diagnosed cases of OSSN from January 2004 to December 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of presentation of OSSN was 45 years (median, 45 years; 2 to 87 years) with male preponderance (74%). The most common age group of presentation was 41\u201360 years (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 299; 39%). The most common type of OSSN was invasive squamous cell carcinoma seen in 50% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 383) eyes followed by severe dysplasia\/carcinoma\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      in 31% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 250) eyes. Tumor infiltration at base was seen in 16% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 124), positive margins in 32% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 248), scleral infiltration in 14% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 109), intraocular extension in 3% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 23), and orbital extension in 4% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 26) eyes. OSSN was associated with actinic keratosis in 21% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 165) cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Based on histopathology, invasive squamous cell carcinoma is the most common form of OSSN in the Asian Indian population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_1313_20","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T15:50:21Z","timestamp":1724946621000},"page":"3-7","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Histopathological spectrum of ocular surface squamous neoplasia"],"prefix":"10.4103","volume":"65","author":[{"given":"Dilip Kumar","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Taneja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uppala","family":"Veena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Kaliki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20240829","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0039-6257(05)80054-2","article-title":"Ocular surface squamous neoplasia","volume":"39","author":"Lee","year":"1995","journal-title":"Surv Ophthalmol"},{"key":"R2-2-20240829","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1001\/archopht.1992.01080160103042","article-title":"Incidence of ocular surface epithelial dysplasia in metropolitan Brisbane. 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