{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:19:25Z","timestamp":1787775565302,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Superior imaging techniques have increased the recognition of adrenal pathology. Distinguishing benign from malignant adrenocortical tumors is not always easy. Several criteria and immunohistochemical markers have been discovered which help to differentiate between adrenocortical adenoma (ACA) and adrenocortical carcinoma (ACC). Our aim here was to evaluate the diagnostic and prognostic role of steroidogenic factor-1 (SF-1) in adult adrenocortical tumors (ACT) diagnosed using the Weiss criteria. In this cohort, we have also analyzed Ki67 and p53 expression and the extent of agreement between SF-1 and Ki-67.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>This was a retrospective, observational study comprising 24 cases of adult ACT over 10 years. Immunohistochemical staining for SF-1, Ki67, and p53 was done in all the cases, and the results correlated with the morphological diagnosis made using Weiss criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>SF-1 was 100% sensitive and 80% specific as a marker of malignancy. Increased SF-1 expression correlated with worse survival. There was a moderate degree of agreement between Ki-67 labeling-index and SF-1 as a marker of malignancy with the kappa coefficient being 0.75. The sensitivity of p53 was lower than Ki67 in diagnosing ACC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In adult ACTs, SF-1 has diagnostic significance and prognostic implication. SF-1 is a crucial, dosage-dependent survival factor in ACC. There is a moderate extent of agreement between Ki-67 and SF-1 as a marker of malignancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_153_21","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T15:35:03Z","timestamp":1724945703000},"page":"814-820","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic and prognostic utility of SF-1 in adrenal cortical tumours"],"prefix":"10.4103","volume":"65","author":[{"given":"Priyanka","family":"Maity","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhituparna","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moumita","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyas","family":"Gargari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Kar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debansu","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satinath","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttara","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20240829","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1210\/er.2002-0031","article-title":"The clinically inapparent adrenal mass: Update in diagnosis and management","volume":"25","author":"Mansmann","year":"2004","journal-title":"Endocr Rev"},{"key":"R2-13-20240829","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/BF03347444","article-title":"Adrenal incidentaloma: Clinical characteristics and comparison between patients with and without extraadrenal malignancy","volume":"30","author":"Tsvetov","year":"2007","journal-title":"J Endocrinol Investig"},{"key":"R3-13-20240829","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000478-198403000-00001","article-title":"Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors","volume":"8","author":"Weiss","year":"1984","journal-title":"Am J Surg Pathol"},{"key":"R4-13-20240829","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.humpath.2009.03.010","article-title":"The Weiss system for evaluating adrenocortical neoplasms: 25 years later","volume":"40","author":"Lau","year":"2009","journal-title":"Hum Pathol"},{"key":"R5-13-20240829","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/his.13255","article-title":"Challenges in surgical pathology of adrenocortical tumours","volume":"72","author":"Erickson","year":"2018","journal-title":"Histopathology"},{"key":"R6-13-20240829","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1002\/1097-0142(19931201)72:11<3296::AID-CNCR2820721127>3.0.CO;2-4","article-title":"Immunohistochemical study of adrenocortical carcinoma. Predictive value of the D11 monoclonal antibody","volume":"72","author":"Tartour","year":"1993","journal-title":"Cancer"},{"key":"R7-13-20240829","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00000478-199801000-00007","article-title":"Immunoreactivity for A103, an antibody to melan-A (Mart-1), in adrenocortical and other steroid tumors","volume":"22","author":"Busam","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"R8-13-20240829","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/jcp.51.2.114","article-title":"Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin","volume":"51","author":"McCluggage","year":"1998","journal-title":"J Clin Pathol"},{"key":"R9-13-20240829","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1677\/joe.0.1610341","article-title":"The expression of inhibin\/activin subunits in the human adrenal cortex and its tumours","volume":"161","author":"Munro","year":"1999","journal-title":"J Endocrinol"},{"key":"R10-13-20240829","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12022-018-9525-8","article-title":"Immunohistochemical biomarkers of adrenal cortical neoplasms","volume":"29","author":"Mete","year":"2018","journal-title":"Endocr Pathol"},{"key":"R11-13-20240829","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/jc.2004-0942","article-title":"Amplification of the steroidogenic factor 1 gene in childhood adrenocortical tumors","volume":"90","author":"Figueiredo","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R12-13-20240829","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12022-013-9291-6","article-title":"Pathology of the adrenal cortex: A reappraisal of the past 25 years focusing on adrenal cortical tumors","volume":"25","author":"Papotti","year":"2014","journal-title":"Endocr Pathol"},{"key":"R13-13-20240829","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/01.MP.0000081730.72305.81","article-title":"Adrenocortical adenoma and carcinoma: Histopathological and molecular comparative analysis","volume":"16","author":"Stojadinovic","year":"2003","journal-title":"Mod Pathol"},{"key":"R14-13-20240829","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/PAI.0b013e3181ddf7b9","article-title":"Distinguishing clear cell renal cell carcinoma, retroperitoneal paraganglioma, and adrenal cortical lesions on limited biopsy material: Utility of immunohistochemical markers","volume":"18","author":"Lapinski","year":"2010","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"R15-13-20240829","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.humpath.2012.07.025","article-title":"Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: A validation study focusing on clinical and pathologic correlates","volume":"44","author":"Duregon","year":"2013","journal-title":"Hum Pathol"},{"key":"R16-13-20240829","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00383-015-3708-x","article-title":"Usefulness of Wieneke criteria in assessing morphologic characteristics of adrenocortical tumors in children","volume":"31","author":"Chatterjee","year":"2015","journal-title":"Pediatr Surg Int"},{"key":"R17-13-20240829","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.jpedsurg.2016.07.014","article-title":"Weineke criteria, Ki-67 index and p53 status to study pediatric adrenocortical tumors: Is there a correlation?","volume":"51","author":"Das","year":"2016","journal-title":"J Pediatr Surg"},{"key":"R18-13-20240829","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.jpedsurg.2018.12.002","article-title":"Diagnostic and prognostic utility of SF-1, IGF2 and p57 immunoexpression in pediatric adrenal cortical tumors","volume":"54","author":"Guntiboina","year":"2019","journal-title":"J Pediatr Surg"},{"key":"R19-13-20240829","first-page":"1040","article-title":"Myxoid adrenal cortical adenoma in an infant: An unusual morphology","volume":"11","author":"Chatterjee","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"R20-13-20240829","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1200\/JCO.2002.20.4.941","article-title":"Adrenocortical carcinoma: Clinical, morphologic, and molecular characterization","volume":"20","author":"Stojadinovic","year":"2002","journal-title":"J Clin Oncol"},{"key":"R21-13-20240829","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12957-015-0527-4","article-title":"Diagnostic and prognostic features in adrenocortical carcinoma: A single institution case series and review of the literature","volume":"13","author":"Wanis","year":"2015","journal-title":"World J Surg Oncol"},{"key":"R22-13-20240829","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1210\/jc.2005-2730","article-title":"Clinical and biological features in the prognosis of adrenocortical cancer: Poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients","volume":"91","author":"Abiven","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R23-13-20240829","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1210\/jc.2013-3020","article-title":"Update in adrenocortical carcinoma","volume":"98","author":"Fassnacht","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"R24-13-20240829","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00000478-198903000-00004","article-title":"Pathologic features of prognostic significance in adrenocortical carcinoma","volume":"13","author":"Weiss","year":"1989","journal-title":"Am J Surg Pathol"},{"key":"R25-13-20240829","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/PAS.0b013e31820bcf21","article-title":"The argument for mitotic rate-based grading for the prognostication of adrenocortical carcinoma","volume":"35","author":"Giordano","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"R26-13-20240829","first-page":"94","article-title":"SF-1 in the development of the adrenal gland and gonads","volume":"59","author":"Ozisik","year":"2003","journal-title":"Horm Res"},{"key":"R27-13-20240829","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1210\/me.2007-0120","article-title":"Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer","volume":"21","author":"Doghman","year":"2007","journal-title":"Mol Endocrinol"},{"key":"R28-13-20240829","doi-asserted-by":"crossref","first-page":"E161","DOI":"10.1210\/jc.2010-0653","article-title":"High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors","volume":"95","author":"Sbiera","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R29-13-20240829","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/sj.bjc.6990691","article-title":"Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization","volume":"81","author":"James","year":"1999","journal-title":"Br J Cancer"},{"key":"R30-13-20240829","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1098-2264(200006)28:2<145::AID-GCC3>3.0.CO;2-7","article-title":"Adrenocortical carcinoma is characterized by a high frequency of chromosomal gains and high-level amplifications","volume":"28","author":"Dohna","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"R31-13-20240829","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1210\/jc.2008-2163","article-title":"Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists","volume":"94","author":"Doghman","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"R32-13-20240829","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1442-2042.2005.00999.x","article-title":"Proliferative activity and genetic changes in adrenal cortical tumors examined by flow cytometry, fluorescence in situ hybridization and immunohistochemistry","volume":"12","author":"Takehara","year":"2005","journal-title":"Int J Urol"},{"key":"R33-13-20240829","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mce.2011.09.010","article-title":"Towards an understanding of the role of p53 in adrenocortical carcinogenesis","volume":"351","author":"Wasserman","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"R34-13-20240829","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1158\/1078-0432.CCR-06-2085","article-title":"Somatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity","volume":"13","author":"Lib\u00e8","year":"2007","journal-title":"Clin Cancer Res"},{"key":"R35-13-20240829","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/0377-4929.155308","article-title":"Histopathological study of adrenocortical masses with special references to Weiss score, Ki-67 index and p53 status","volume":"58","author":"Mukherjee","year":"2015","journal-title":"Indian J Pathol Microbiol"},{"key":"R36-13-20240829","doi-asserted-by":"crossref","first-page":"665","DOI":"10.5858\/2009-0637-RSR.1","article-title":"Epithelioid angiomyolipoma: A morphologically distinct variant that mimics a variety of intra-abdominal neoplasms","volume":"135","author":"Mete","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"R37-13-20240829","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1385\/EP:12:4:429","article-title":"Pathologic features and expression of insulin-like growth factor-2 in adrenocortical neoplasms","volume":"12","author":"Erickson","year":"2001","journal-title":"Endocr Pathol"},{"key":"R38-13-20240829","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-2559.2006.02505.x","article-title":"IGFII and MIB1 immunohistochemistry is helpful for the differentiation of benign from malignant adrenocortical tumours","volume":"49","author":"Schmitt","year":"2006","journal-title":"Histopathology"},{"key":"R39-13-20240829","doi-asserted-by":"crossref","first-page":"E1284","DOI":"10.1210\/jc.2012-1184","article-title":"SNP array profiling of childhood adrenocortical tumors reveals distinct pathways of tumorigenesis and highlights candidate driver genes","volume":"97","author":"Letouze","year":"2012","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_153_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:32:01Z","timestamp":1787772721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_153_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_153_21","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}