{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:25:52Z","timestamp":1783416352238,"version":"3.54.6"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Renal cell carcinoma (RCC) is a notorious tumor, known for its unpredictable metastatic behavior; however, metastasis to the testis remains exceptionally rare. We report an unusual case of incidentally detected testicular metastasis from renal cell carcinoma in a patient who was undergoing treatment for coexistent prostatic adenocarcinoma. A 70-year-old man presented with lower urinary tract symptoms and hematuria and was diagnosed with high-grade prostatic adenocarcinoma, for which transurethral resection of the prostate and bilateral orchidectomy were performed. Histopathological examination of the orchidectomy specimen unexpectedly revealed metastatic RCC. On reviewing prior medical records, a history of left radical nephrectomy for clear cell RCC 7 years earlier was noted, confirming a late and isolated ipsilateral testicular metastasis. Subsequent imaging did not demonstrate disease at any other site. This case highlights the remarkable latency and unpredictable metastatic potential of RCC and emphasizes the importance of careful histopathological evaluation of specimens removed for unrelated primary malignancies.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_153_26","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:55:24Z","timestamp":1782852924000},"page":"374-376","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Metachronous renal cell carcinoma with delayed testicular metastasis coexisting with synchronous prostatic adenocarcinoma"],"prefix":"10.4103","volume":"69","author":[{"given":"Sunila","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Pathology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Chadha","sequence":"additional","affiliation":[{"name":"Department of Urology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Ali","family":"Osama","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"R1-20260707","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1038\/nrdp.2017.9","article-title":"Renal cell carcinoma","volume":"3","author":"Hsieh","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"R2-20260707","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/IJCA_2005424_173","article-title":"Pattern of metastases in renal cell carcinoma: A single institution study","volume":"42","author":"Sivaramakrishna","year":"2005","journal-title":"Indian J Cancer"},{"key":"R3-20260707","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.3390\/jcm12175636","article-title":"Testicular metastasis from renal cell carcinoma: A systematic review","volume":"12","author":"Pliszka","year":"2023","journal-title":"J Clin Med"},{"key":"R4-20260707","doi-asserted-by":"crossref","first-page":"22","DOI":"10.15586\/jkcvhl.v9i2.212","article-title":"Renal cell carcinoma with testicular metastases: A case report and review of the literature","volume":"9","author":"Yoshitake","year":"2022","journal-title":"J Kidney Cancer VHL"},{"key":"R5-20260707","first-page":"102299","article-title":"Rare presentation of a clear cell renal cell carcinoma metastasis to the contralateral testicle: A case report","volume":"46","author":"Thomson","year":"2022","journal-title":"Urol Case Rep"},{"key":"R6-20260707","first-page":"9394680","article-title":"Metastatic renal cell carcinoma to the testis: A clinicopathologic analysis of five cases","volume":"2020","author":"Wang","year":"2020","journal-title":"Case Rep Pathol"},{"key":"R7-20260707","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.humpath.2023.06.002","article-title":"Metastatic solid tumors to the testis: A clinicopathologic evaluation of 157 cases from an international collaboration","volume":"139","author":"Nova-Camacho","year":"2023","journal-title":"Hum Pathol"},{"key":"R8-20260707","first-page":"2008","article-title":"Management of metastatic renal cell carcinoma in the era of targeted therapies","volume":"33","author":"Ball","year":"2015","journal-title":"J Clin Oncol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijpm.ijpm_153_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:02:13Z","timestamp":1783414933000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/ijpm.ijpm_153_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_153_26","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-02-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}