{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:26:21Z","timestamp":1787757981022,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vulvar cancer has an incidence of 2\u20133 per 100,000 women and accounts for 5% of all female genital tract (FGT) malignancies. About 90% of them are squamous cell carcinoma (SCC). Primary malignant glandular tumors of the vulva (PMGTV) are rare, diverse tumors with different prognoses and differentials. We present three cases of PMGTV diagnosed at our institution over 11 years (2013\u20132023) in the present study. Hospital intranet and medical records provided required clinical, histopathology, and immunohistochemistry (IHC) data. There were only three reported cases of PMGTV. The most common presentation was a painful mass growing rapidly. Most of the tumors were high-grade, and IHC was required for a definite diagnosis. A spectrum of variable entities was diagnosed, namely, adenoid cystic carcinoma (ADC), adenocarcinoma intestinal type, and adenocarcinoma of mammary gland type (AMGT). PMGTVs are rare entities and resemble morphologically and immunophenotypically tumors of other systemic sites, making exclusion of any primary malignancy mandatory. A large panel of immunohistochemistry is needed to typify them. Due to the rarity of the disease, no definite treatment guidelines are present.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_176_25","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:00:10Z","timestamp":1780560010000},"page":"338-342","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Primary malignant glandular tumor of the vulva: A three-case series and review of literature"],"prefix":"10.4103","volume":"69","author":[{"given":"Varnika","family":"Rai","sequence":"first","affiliation":[{"name":"Onco-Pathology Department, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Saha","sequence":"additional","affiliation":[{"name":"Onco-Pathology Department, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailee","family":"Mehta","sequence":"additional","affiliation":[{"name":"Onco-Pathology Department, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Toshniwal","sequence":"additional","affiliation":[{"name":"Onco-Pathology Department, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Onco-Pathology Department, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"R1-20260707","first-page":"11","article-title":"Cancer statistics","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"R2-20260707","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/his.14609","article-title":"Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition","volume":"80","author":"McCluggage","year":"2022","journal-title":"Histopathology"},{"key":"R3-20260707","doi-asserted-by":"crossref","first-page":"e31744","DOI":"10.1097\/MD.0000000000031744","article-title":"Adenoid cystic carcinoma of the Bartholin's gland is easily misdiagnosed: A case report and literature review","volume":"101","author":"Wang","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"R4-20260707","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/PGP.0000000000000324","article-title":"Frequent NFIB-associated gene rearrangement in adenoid cystic carcinoma of the vulva","volume":"36","author":"Xing","year":"2017","journal-title":"Int J Gynecol Pathol"},{"key":"R5-20260707","first-page":"589","article-title":"Adenoid cystic carcinoma of the salivary gland","volume":"51","author":"Budd","year":"1983","journal-title":"Sustained complete response to chemotherapy. Cancer"},{"key":"R6-20260707","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.3390\/cancers14205171","article-title":"\u201cIntestinal-type\u201dvulvar adenocarcinoma: A review of the MITO rare tumors group","volume":"14","author":"Dellino","year":"2022","journal-title":"Cancers"},{"key":"R7-20260707","doi-asserted-by":"crossref","first-page":"19084","DOI":"10.7812\/TPP\/19.084","article-title":"Primary breast carcinoma other vulva metastatic to lymph nodes and bones: A case report and literature review","volume":"24","author":"Ananthula","year":"2020","journal-title":"Perm J"},{"key":"R8-20260707","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00004347-200210000-00006","article-title":"Neuroendocrine marker expression in cervical carcinomas of non-small cell type","volume":"21","author":"Chavez-Blanco","year":"2002","journal-title":"Int J Gynecol Pathol"},{"key":"R9-20260707","doi-asserted-by":"crossref","first-page":"e1318","DOI":"10.1634\/theoncologist.2020-0081","article-title":"The clinical significance of neuroendocrine features in invasive breast carcinomas","volume":"25","author":"Lai","year":"2020","journal-title":"Oncologist"},{"key":"R10-20260707","first-page":"47","article-title":"Metastatic and secondary tumors of the vulva","volume":"42","author":"Dehner","year":"1973","journal-title":"Obstet Gynecol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_176_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:58:52Z","timestamp":1787756332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_176_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_176_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-02-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}