{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:26:07Z","timestamp":1787765167778,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cryptococcosis usually occurs in immunocompromised patients and presents as meningitis and lung disease. Adrenal gland involvement may be observed, yet primary adrenal insufficiency by cryptococcal infection is infrequent. We present a case of a middle-aged immunocompetent man with primary adrenal insufficiency and bilateral adrenal lesions, splenomegaly, and miliary mottling in the lungs on imaging. No evidence of meningitis was witnessed. The clinico-radiological findings led toward the differential diagnosis of disseminated tuberculosis or fungal infection. Detection of cryptococcus organism was done on fine-needle aspiration cytology and biopsy on periodic acid-Schiff stain and Gomori`s methenamine silver stain. Thus, it is recommended to keep the possibility of cryptococcosis in mind while dealing with instances that have a tuberculosis-like clinico-radiological presentation. The detection of the causal organism on Fine needle aspiration (FNA)\/biopsy examination may be useful in confirming the diagnosis and determining the appropriate medical treatment.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_185_22","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T23:00:35Z","timestamp":1705014035000},"page":"438-440","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Bilateral adrenal cryptococcosis causing adrenal insufficiency in an immunocompetent patient"],"prefix":"10.4103","volume":"67","author":[{"given":"Ramneek","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Pathology, Dayanand Medical College & Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dayanand Medical College & Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College & Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College & Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"R1-20240829","first-page":"1061","article-title":"Clinical endocrinology in India","volume":"79","author":"Kochupillai","year":"2000","journal-title":"Curr Sci"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/dc.23467","article-title":"Fine-needle aspiration cytology of non-neoplastic adrenal pathology","volume":"44","author":"Kumar","year":"2016","journal-title":"Diagn Cytopathol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4103\/0377-4929.107781","article-title":"Spectrum of adrenal lesions on \ufb01ne needle aspiration cytology","volume":"55","author":"Rana","year":"2012","journal-title":"Indian J Pathol Microbiol"},{"key":"R4-20240829","first-page":"20499361211014769","article-title":"Cryptococcosis complicating diabetes mellitus:A scoping review","volume":"8","author":"Nsenga","year":"2021","journal-title":"Ther Adv Infect Dis"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/1471-2334-11-340","article-title":"Successful management of cryptococcosis of the bilateral adrenal glands and liver by unilateral adrenalectomy with antifungal agents:A case report","volume":"11","author":"Matsuda","year":"2011","journal-title":"BMC Infect Dis"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2169\/internalmedicine.56.7356","article-title":"Disseminated Cryptococcosis with Adrenal Insufficiency and Meningitis in an Immunocompetent Individual","volume":"56","author":"Ito","year":"2017","journal-title":"Intern Med"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijid.2005.08.001","article-title":"Adrenal infections","volume":"10","author":"Paolo","year":"2006","journal-title":"Int J Infect Dis"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_185_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:02:29Z","timestamp":1787763749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_185_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,6]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_185_22","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,6]]},"assertion":[{"value":"2022-02-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}