{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:49:15Z","timestamp":1787071755618,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Objective:<\/jats:title>\n The aim is to differentiate light-chain-restricted hematogones (LCR-HGs) from B-cell lymphoma.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n We identified eight patients who underwent bone marrow (BM) flow cytometry (FLC) diagnosis or evaluation for lymphoma\/multiple myeloma.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Among the eight cases, there are two chronic lymphocytic leukemia, one marginal zone lymphoma, one mantle cell lymphoma, one multiple myeloma, one hepar diffuse large B-cell lymphoma, and one monomorphic epitheliotropic intestinal T-cell lymphoma, in whom FLC immunophenotypes of BM-aspirated specimens showed LCR-HGs.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Failure to recognize LCR-HGs and diagnostic test interference associated with antibody-based therapies leads to erroneous diagnosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_188_25","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T07:00:10Z","timestamp":1763449210000},"page":"766-768","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Light-chain-restricted hematogones are a potential diagnostic pitfall for B-cell lymphoma"],"prefix":"10.4103","volume":"68","author":[{"given":"Xiaofeng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, The Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China"},{"name":"Hebei Key Laboratory of Panvascular Diseases, Chengde, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China"},{"name":"Hebei Key Laboratory of Panvascular Diseases, Chengde, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"key":"R1-20251208","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1023\/A:1006659401385","article-title":"The effect of age on the B-cell repertoire","volume":"20","author":"Weksler","year":"2000","journal-title":"J Clin Immunol"},{"key":"R2-20251208","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF02890420","article-title":"Lymphadenitis and lymphoproliferative lesions associated with the human herpes virus-6 (HHV-6)","volume":"61","author":"Borisch","year":"1991","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"R3-20251208","first-page":"265","article-title":"The new lymphotropic herpesviruses (HHV-6, HHV-7, HHV-8) and hepatitis C virus (HCV) in human lymphoproliferative diseases:An overview","volume":"81","author":"Luppi","year":"1996","journal-title":"Haematologica"},{"key":"R4-20251208","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/labmed\/lmw009","article-title":"Hematogones with lambda light chain restriction in a 4-year-old boy with burkitt lymphoma:A potential diagnostic pitfall","volume":"47","author":"Guillory","year":"2016","journal-title":"Lab Med"},{"key":"R5-20251208","doi-asserted-by":"crossref","first-page":"106704","DOI":"10.1016\/j.leukres.2021.106704","article-title":"Hematogones with light chain restriction:A potential diagnostic pitfall when using flow cytometry analysis to assess bone marrow specimens","volume":"111","author":"El","year":"2021","journal-title":"Leuk Res"},{"key":"R6-20251208","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4049\/jimmunol.1501351","article-title":"The therapeutic CD38 monoclonal antibody daratumumab induces programmed cell death via Fc? receptor-mediated cross-linking","volume":"197","author":"Overdijk","year":"2016","journal-title":"J Immunol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_188_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:53:36Z","timestamp":1787068416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_188_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_188_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-02-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}