{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:25:18Z","timestamp":1787757918625,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Co-expressions of receptor tyrosine kinases such as c-MET and HER2 were reported in many studies. The concomitant expression is associated with more aggressive clinical course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>In this study, it was intended to investigate the correlation of the positivity of c-MET and HER2 with histopathologic findings and their impacts on prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>\n                      After the decision of the ethics committee, a total of 64 cases, whose HER 2 status was studied by dual silver\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      hybridization\/immunohistochemistry method, were included in the study. Immunohistochemical staining for c-MET was performed to all cases and the evaluation was performed similarly to the criteria for HER2 evaluation, but cytoplasmic staining was also considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>The data were analyzed using SPSS 20 for Windows.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      c-MET positivity which is considered by the score of 2+ and 3+ was found only in 34.4% of HER2 positive cases while it was 59.3% in HER2 negative cases (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.045). The sole histopathological feature associated with c-MET positivity was distal gastric localization (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Even though higher rates of c-MET positivity in HER2 positive cases were stated in the literature, contrary results were obtained in this study. Comparing the HER2+\/c-MET + co-expression group with the other groups, no difference was found about age, sex, macroscopic and microscopic characteristics. The presence of c-MET positivity in cases with HER2 expression suggests that c-MET expression might be associated with the resistance to Trastuzumab.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_23_21","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T06:15:36Z","timestamp":1654150536000},"page":"786-790","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression"],"prefix":"10.4103","volume":"65","author":[{"given":"Ferhat","family":"Coskun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semin","family":"Ayhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayca","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydin","family":"Isisag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240829","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/bjc.2012.237","article-title":"MET in gastric carcinomas: Comparison between protein expression and gene copy number and impact on clinical outcome","volume":"107","author":"Lee","year":"2012","journal-title":"Br J Cancer"},{"key":"R2-8-20240829","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4251\/wjgo.v7.i11.317","article-title":"Clinical significance of MET in gastric cancer","volume":"7","author":"Inokuchi","year":"2015","journal-title":"World J Gastrointest Oncol"},{"key":"R3-8-20240829","first-page":"1477","article-title":"The overexpression of c-met as a prognostic indicator for gastric carcinoma compared to p53 and p21 nuclear accumulation","volume":"19","author":"Drebber","year":"2008","journal-title":"Oncol Rep"},{"key":"R4-8-20240829","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9<1894::AID-CNCR3>3.0.CO;2-J","article-title":"The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas","volume":"85","author":"Nakajima","year":"1999","journal-title":"Cancer"},{"key":"R5-8-20240829","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.5301\/jbm.5000171","article-title":"Concordance rate between HER2 immunohistochemistry and in situ hybridization in gastric carcinoma: Systematic review and meta-analysis","volume":"31","author":"Pyo","year":"2016","journal-title":"Int J Biol Markers"},{"key":"R6-8-20240829","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1746-1596-7-57","article-title":"The clinicopathologic association of c-MET overexpression in Iranian gastric carcinomas; 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