{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:13Z","timestamp":1787070913391,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic toggle=\"yes\">BCR::ABL1<\/jats:italic>\n                    translocation and\n                    <jats:italic toggle=\"yes\">JAK2V617F<\/jats:italic>\n                    mutations are canonical variants of myeloproliferative neoplasms (MPNs). Traditionally considered mutually exclusive, they may rarely coexist. We report the clinicopathological profile and treatment outcomes of four MPN patients with coexistence of these disease-defining genetic variants. Both mutations were detected simultaneously in three patients who did not harbor tell-tale signs of CML and were evaluated for both\n                    <jats:italic toggle=\"yes\">BCR::ABL1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">JAK2V617F<\/jats:italic>\n                    based on clues from hemogram, peripheral-blood and bone-marrow examination. All were treated with imatinib and hydroxyurea and attained major molecular response after 2\u20137 months. In another patient,\n                    <jats:italic toggle=\"yes\">JAK2V617F<\/jats:italic>\n                    was detected 15 years after the diagnosis of CML at the time of evaluation of loss of hematological and molecular response. She was treated with dasatinib but no hematologic or molecular response was attained after 6 months despite good compliance. In conclusion,\n                    <jats:italic toggle=\"yes\">BCR::ABL1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">JAK2V617F<\/jats:italic>\n                    may rarely coexist in MPN with variable temporal evolution, clinicopathological profile, and treatment response.\n                  <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_240_24","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T09:01:18Z","timestamp":1720429278000},"page":"592-595","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of BCR::ABL1 translocation and JAK2V617F mutations in indian patients with myeloproliferative neoplasms: A case series"],"prefix":"10.4103","volume":"68","author":[{"given":"Durgadevi","family":"Sundaresan","sequence":"first","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debadrita","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charanpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithye","family":"Parvathy","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpesh","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riju Rani","family":"Deka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jogeshwar","family":"Binota","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shano","family":"Naseem","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"R1-20251031","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/modpathol.2017.182","article-title":"Myeloproliferative neoplasms with concurrent BCR-ABL1 translocation and JAK2 V617F mutation:A multi-institutional study from the bone marrow pathology group","volume":"31","author":"Soderquist","year":"2018","journal-title":"Mod Pathol"},{"key":"R2-20251031","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/bjh.13932","article-title":"BCR-ABL1-positive and JAK2 V617F-positive clones in 23 patients with both aberrations reveal biologic and clinical importance","volume":"176","author":"Martin-Cabrera","year":"2017","journal-title":"Br J Haematol"},{"key":"R3-20251031","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s12308-021-00458-4","article-title":"Sequential development of JAK2V617F and BCR-ABL1:A ``double-hit''myeloproliferative neoplasm with morphologic transition","volume":"14","author":"Zhao","year":"2021","journal-title":"J Hematopathol"},{"key":"R4-20251031","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1182\/blood-2011-07-365007","article-title":"Concomitant occurrence of BCR-ABL and JAK2V617F mutation","volume":"118","author":"Pieri","year":"2011","journal-title":"Blood"},{"key":"R5-20251031","doi-asserted-by":"crossref","first-page":"1329298","DOI":"10.3389\/fonc.2023.1329298","article-title":"Co-occurrence of JAK2-V617 F mutation and BCR::ABL1 translocation in chronic myeloproliferative neoplasms:A potentially confounding genetic combination","volume":"13","author":"Zanelli","year":"2024","journal-title":"Front Oncol"},{"key":"R6-20251031","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12288-017-0781-4","article-title":"BCR-ABL and JAK2V617F Mutation co-existence, rare or just unexplored","volume":"33","author":"Darling","year":"2017","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R7-20251031","doi-asserted-by":"crossref","first-page":"23","DOI":"10.14740\/jh591","article-title":"Emergence of BCR-ABL1 chronic myeloid leukemia in a JAK2-V617F polycythemia vera","volume":"9","author":"Lorenzo","year":"2020","journal-title":"J Hematol"},{"key":"R8-20251031","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1080\/16078454.2022.2108902","article-title":"JAK2 V617f in chronic myeloid leukemia:Driving force or passive bystander?","volume":"27","author":"Tarantini","year":"2022","journal-title":"Hematology"},{"key":"R9-20251031","first-page":"4610","volume":"138","author":"Ali","year":"2021","journal-title":"Concomitant JAK2 and BCR-ABL1 in patients with chronic myeloid leukemia clinical impact and response to therapy:A systematic review Blood"},{"key":"R10-20251031","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5045\/br.2019.54.1.77","article-title":"Coexistence of BCR\/ABL1-positive chronic myeloid leukemia and JAK2 V617F-mutated myelofibrosis successfully treated with dasatinib and ruxolitinib","volume":"54","author":"Yi","year":"2019","journal-title":"Blood Res"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_240_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:49Z","timestamp":1787067529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_240_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_240_24","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]},"assertion":[{"value":"2024-03-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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