{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:30:02Z","timestamp":1789057802642,"version":"build-2803163510"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The prolongation in APTT reflects various disorders affecting the blood coagulation system. Automated coagulation analyzers such as ACL TOP, help in evaluating the clotting cascade by displaying clot reaction curves or waveforms. The fibrin formation curve forms S-shaped curve showing the changes in the absorbance on X-axis and time in seconds on Y-axis. The clotting data is processed to obtain derivatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This observational study analyzed 80 samples including 20 samples from normal healthy individuals as control. The parameters studied were time (secs), height (mAbs), and width (secs) of first derivative (FD), fibrin clot time at \u00bd height, height (mAbs), and width (secs) of both first and second peaks of second derivative (SD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result and Discussion:<\/jats:title>\n                    <jats:p>Hemophilia (n = 13) that consisted of factor VIII deficiency (n = 11) and factor IX deficiency (n = 2) showed biphasic patterns in both first DC and second DC. Cases with thrombosis (n = 8) showed marked elevation in first DC. Various other disorders (n = 39) that consisted of mainly hepatic dysfunction (n = 24) showed prolongation in fibrin formation, first DC, and second DC peak time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The atypical derivative curve analysis helps in determining the interferences in clotting cascade. It gives significant information and provides direction for further testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_257_24","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T09:25:40Z","timestamp":1725269140000},"page":"137-140","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Clot waveform analysis of prolonged activated partial thromboplastin time in various disorders"],"prefix":"10.4103","volume":"68","author":[{"given":"Apeksha","family":"Kadu","sequence":"first","affiliation":[{"name":"Department of Pathology, B. J. Medical College, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pathology, B. J. Medical College, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansa","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Pathology, B. J. Medical College, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"R1-20250411","doi-asserted-by":"crossref","first-page":"1076029620978810","DOI":"10.1177\/1076029620978810","article-title":"The first-derivative curve of the coagulation waveform reveals the cause of aPTT prolongation","volume":"26","author":"Shimomura","year":"2020","journal-title":"Clin Appl Thromb Hemost"},{"key":"R2-20250411","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1751-553X.2010.01248.x","article-title":"A study of atypical APTT derivative curves on the ACL TOP coagulation analyser","volume":"33","author":"Solano","year":"2010","journal-title":"Int J Lab Hematol"},{"key":"R3-20250411","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/MBC.0000000000000728","article-title":"Activated partial thromboplastin time derivative curves","volume":"29","author":"Esmedere","year":"2018","journal-title":"Blood Coagul Amp Fibrinolysis"},{"key":"R4-20250411","doi-asserted-by":"crossref","first-page":"1076029620912027","DOI":"10.1177\/1076029620912027","article-title":"Update on the clot waveform analysis","volume":"26","author":"Wada","year":"2020","journal-title":"Clin Appl Thromb Hemost"},{"key":"R5-20250411","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/MBC.0000000000000436","article-title":"Usefulness of the second-derivative curve of activated partial thromboplastin time on the ACL-TOP coagulation analyzer for detecting factor deficiencies","volume":"27","author":"Tokunaga","year":"2016","journal-title":"Blood Coagul Amp Fibrinolysis"},{"key":"R6-20250411","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/medicina59061169","article-title":"Isolated prolongation of activated partial thromboplastin time:Not just bleeding risk!","volume":"59","author":"Santoro","year":"2023","journal-title":"Medicina"},{"key":"R7-20250411","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12959-019-0201-0","article-title":"Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk","volume":"17","author":"Suzuki","year":"2019","journal-title":"Thromb J"},{"key":"R8-20250411","doi-asserted-by":"crossref","first-page":"14186","DOI":"10.1038\/s41598-020-71063-1","article-title":"Assessment of aPTT-based clot waveform analysis for the detection of haemostatic changes in different types of infections","volume":"10","author":"Tan","year":"2020","journal-title":"Sci Rep"},{"key":"R9-20250411","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/1076029617724230","article-title":"An evaluation of the activated partial thromboplastin time waveform","volume":"24","author":"Matsumoto","year":"2017","journal-title":"Clin Appl Thromb Hemost"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_257_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:52:02Z","timestamp":1786647122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_257_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_257_24","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"2024-04-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}