{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:31:15Z","timestamp":1787841075390,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Liposarcoma is one of the most common soft-tissue sarcomas that originates from adipose tissue. Primary uterine liposarcoma is extremely rare. With the MDM2, negative is even rarer. We report a 37-year-old woman presented with lower abdominal discomfort and increase in vaginal secretions for more than 2 months. The ultrasonography revealed a hypoechoic mass sized 81 \u00d7 73 \u00d7 67 mm in the right adnexal area. Histopathologically, the neoplasm was mainly composed of mature adipose tissue, a small number of scattered lipoblasts, and the spindle cell which with mild atypia. Immunohistochemistry showed that the tumor cells were positive for CDK4 but negative for MDM2, and FISH analysis showed no MDM2 amplification. The patient only underwent tumor excision and is currently doing well.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_263_23","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T11:00:38Z","timestamp":1733482838000},"page":"907-910","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Primary liposarcoma of the uterus with MDM2 negative"],"prefix":"10.4103","volume":"67","author":[{"given":"Shufei","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Pathology, Jiujiang University Affiliated Hospital, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lushun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jiujiang University Affiliated Hospital, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jiujiang No. 1 Hospital, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jiujiang University Affiliated Hospital, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"R1-20241206","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4329\/wjr.v4.i2.58","article-title":"Diagnostic challenge of lipomatous uterine tumors in three patients","volume":"4","author":"Chu","year":"2012","journal-title":"World J Radiol"},{"key":"R2-20241206","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000272630","article-title":"Liposarcoma of the uterus","volume":"36","author":"Schneebauer","year":"1996","journal-title":"Gynakol Geburtshilfliche Rundsch"},{"key":"R3-20241206","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1055\/s-2007-1022273","article-title":"Liposarcoma of the uterus--A case report","volume":"56","author":"Schmidt","year":"1996","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"R4-20241206","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/01.pgp.0000092156.33490.89","article-title":"Pleomorphic liposarcoma of the uterus:Case report and literature review","volume":"22","author":"Levine","year":"2003","journal-title":"Int J Gynecol Pathol"},{"key":"R5-20241206","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1136\/ijgc-00009577-200511000-00047","article-title":"Uterine liposarcoma in a young woman:A case report","volume":"15","author":"Karateke","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"R6-20241206","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00404-007-0486-2","article-title":"A myxoid liposarcoma arising in a leiomyoma of the uterus:A case report","volume":"277","author":"Hong","year":"2008","journal-title":"Arch Gynecol Obstet"},{"key":"R7-20241206","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/PGP.0b013e31820086a4","article-title":"Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation","volume":"30","author":"Fadare","year":"2011","journal-title":"Int J Gynecol Pathol"},{"key":"R8-20241206","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/PAS.0b013e31820414f7","article-title":"Liposarcoma arising in uterine lipoleiomyoma:A report of 3 cases and review of the literature","volume":"35","author":"McDonald","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"R9-20241206","first-page":"171","article-title":"Liposarcoma of the uterine corpus coexisting with preinvasive cervical cancer--A case report","volume":"57","author":"Sosnik","year":"2006","journal-title":"Pol J Pathol"},{"key":"R10-20241206","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/PGP.0b013e31823f841f","article-title":"Uterine lipoleiomyosarcoma:Report of 2 cases and review of the literature","volume":"31","author":"Lee","year":"2012","journal-title":"Int J Gynecol Pathol"},{"key":"R11-20241206","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/PGP.0000000000000241","article-title":"Pleomorphic liposarcoma arising in a lipoleiomyosarcoma of the uterus:Report of a case with genetic profiling by a next generation sequencing panel","volume":"35","author":"Schoolmeester","year":"2016","journal-title":"Int J Gynecol Pathol"},{"key":"R12-20241206","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.gore.2018.10.008","article-title":"Liposarcoma of the uterine corpus:A case report and literature review","volume":"26","author":"Kiuchi","year":"2018","journal-title":"Gynecol Oncol Rep"},{"key":"R13-20241206","doi-asserted-by":"crossref","first-page":"7474191","DOI":"10.1177\/17588359221081073","article-title":"Overview of systemic therapy options in liposarcoma, with a focus on the activity of selinexor, a selective inhibitor of nuclear export in dedifferentiated liposarcoma","volume":"14","author":"Thirasastr","year":"2022","journal-title":"Ther Adv Med Oncol"},{"key":"R14-20241206","doi-asserted-by":"crossref","first-page":"70","DOI":"10.32074\/1591-951X-213","article-title":"The 2020 WHO classification of soft tissue tumours:News and perspectives","volume":"113","author":"Sbaraglia","year":"2021","journal-title":"Pathologica"},{"key":"R15-20241206","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/nar\/gkaa1273","article-title":"The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma","volume":"49","author":"Lago","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"R16-20241206","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/path.5749","article-title":"The molecular landscape of well differentiated retroperitoneal liposarcoma","volume":"255","author":"Tyler","year":"2021","journal-title":"J Pathol"},{"key":"R17-20241206","doi-asserted-by":"crossref","first-page":"812089","DOI":"10.1155\/2015\/812089","article-title":"Fluorescence in situ hybridization for MDM2 amplification as a routine ancillary diagnostic tool for suspected well-differentiated and dedifferentiated liposarcomas:Experience at a tertiary center","volume":"2015","author":"Thway","year":"2015","journal-title":"Sarcoma"},{"key":"R18-20241206","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/cancers14061362","article-title":"Targetable pathways in the treatment of retroperitoneal liposarcoma","volume":"14","author":"Casadei","year":"2022","journal-title":"Cancers (Basel)"},{"key":"R19-20241206","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/SLA.0000000000003453","article-title":"Histologic subtype defines the risk and kinetics of recurrence and death for primary extremity\/truncal liposarcoma","volume":"273","author":"Bartlett","year":"2021","journal-title":"Ann Surg"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_263_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:39:55Z","timestamp":1787837995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_263_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_263_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]},"assertion":[{"value":"2023-04-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}