{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:30:36Z","timestamp":1787841036775,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:<\/jats:title>\n The objective is to explore clinicopathological characteristics, diagnosis, differential diagnoses, treatment, and prognoses of placental chorioangioma (PCA).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n The pathological data of 30 cases of PCA were collected; the color Doppler ultrasound, Down\u2019s screening, fetal survival, and pathological characteristics were observed; and the literature was reviewed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Of the 30 patients, the ages ranged from 20 to 38 years, with an average of 29.6 years. Pregnancy comorbidity occurred in 14 patients; intrauterine fetal death occurred in 4; the gross appearance of the tumor: a reddish-brown nodule, slightly round, 0.5\u20138 cm in diameter, can be seen on the cut surface of the placenta Pregnancy comorbidity occurred in 14 patients and intrauterine fetal death in 4. On sectioning the placenta, tumors grossly appeared as reddish-brown nodules, slightly round and ranging in diameter from 0.5 to 8 cm. Microscopically, the tumor has small, densely packed capillaries with fibrous connective tissue in the stroma. There were 10 cases with high risk of Down\u2019s syndrome screening, and the immunophenotype CD34 (+) and Ki-67 proliferation index were less than 10%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n PCA is rare and may be misdiagnosed as malignant tumor, which may be related to pregnancy comorbidity and high risk of Down\u2019s screening, so improving the understanding of PCA can provide the basis for clinical diagnosis and intervention. PCA is a rare tumor which may be misdiagnosed as a malignancy. It may be related to pregnancy comorbidity and high risk of Down\u2019s screening. Improving the understanding of PCA could provide the basis for clinical diagnosis and intervention.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_266_23","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T10:16:51Z","timestamp":1712053011000},"page":"770-774","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological characteristics of placental chorioangioma: A clinicopathological study of 30 cases"],"prefix":"10.4103","volume":"67","author":[{"given":"Yuanyin","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pathology, Mindong Hospital Affiliated to Fujian Medical University, F\u00faan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mindong Hospital Affiliated to Fujian Medical University, F\u00faan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mindong Hospital Affiliated to Fujian Medical University, F\u00faan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maohua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mindong Hospital Affiliated to Fujian Medical University, F\u00faan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"R1-20241206","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2147\/IJWH.S72178","article-title":"Placental tumor (chorioangioma) as a cause of polyhydramnios:A case report","volume":"6","author":"Abdalla","year":"2014","journal-title":"Int J Womens Health"},{"key":"R2-20241206","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejogrb.2015.12.009","article-title":"Clinical analysis of 26 patients with histologically proven placental chorioangiomas","volume":"199","author":"Wu","year":"2016","journal-title":"Eur J Obstet Gyn Reprod Biol"},{"key":"R3-20241206","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1515\/jpm-2013-0170","article-title":"Placental chorioangioma:Literature review","volume":"42","author":"Fan","year":"2014","journal-title":"J Perinat Med"},{"key":"R4-20241206","first-page":"913878","article-title":"Chorioangioma of placenta:A rare placental cause for adverse fetal outcome","volume":"2012","author":"Kodandapani","year":"2012","journal-title":"Case Rep Obstet Gynecol"},{"key":"R5-20241206","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/hupa.2000.9036","article-title":"Villous capillary lesions of the placenta:Distinctions between chorangioma, chorangiomatosis, and chorangiosis","volume":"31","author":"Ogino","year":"2000","journal-title":"Hum Pathol"},{"key":"R6-20241206","first-page":"71","article-title":"Chorangiosis. An important placental sign of neonatal morbidity and mortality","volume":"108","author":"Altshuler","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"R7-20241206","first-page":"926743","article-title":"Prenatal diagnosis and fetomaternal outcomes of two cases with placental chorioangioma","volume":"2013","author":"Artunc","year":"2013","journal-title":"Case Rep Obstet Gynecol"},{"key":"R8-20241206","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/jcu.22101","article-title":"Natural history and pregnancy outcome in patients with placental chorioangioma","volume":"42","author":"Liu","year":"2014","journal-title":"J Clin Ultrasound"},{"key":"R9-20241206","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1148\/rg.274065207","article-title":"Best cases from the AFIP:Placental chorioangioma","volume":"27","author":"Kirkpatrick","year":"2007","journal-title":"Radiographics"},{"key":"R10-20241206","first-page":"113","article-title":"Placental chorioangioma as the cause of non-immunologic hydrops fetalis;a case report","volume":"21","author":"Duro","year":"2011","journal-title":"Iran J Pediatr"},{"key":"R11-20241206","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.placenta.2010.11.001","article-title":"Three-dimensional ultrasound evaluation of the placenta","volume":"32","author":"Hata","year":"2011","journal-title":"Placenta"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_266_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:39:57Z","timestamp":1787837997000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_266_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_266_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"assertion":[{"value":"2023-04-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}