{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:30:39Z","timestamp":1787841039357,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Skin appendage tumors (SATs) are benign and malignant neoplasms. Although there are many studies on their clinical features and epidemiology in the literature, most of these studies have a small number of patients and are not classified according to the WHO 2018 classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to reveal the clinical and histopathological features of the SATs and compare the pre-diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Cases diagnosed with SATs in the last 7 years in the Pathology Department were re-evaluated according to the WHO 2018 classification. Patients\u2019 ages and genders, as well as the location and pre-diagnosis of the lesion, were all recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 437 patients, 198 (45.3%) male and 239 (54.7%) female, were included in the study. Of 437 patients, 399 (91.3%) were diagnosed with benign SATs and 38 (8.7%) were diagnosed with malignant SATs. Most of the cases were benign tumors with follicular differentiation. Malignant SATs were seen in patients significantly older than benign ones. The majority of SATs were in head and neck localization. Mammary Paget\u2019s disease was the most common malignant SAT (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 14, 36.8% of patients diagnosed with malignant SATs). It was noted that clinicians were less likely to consider a specific diagnosis of SAT before excision.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SAT, a diagnosis that can be seen at any age and is difficult to predict clinically, may be malignant, especially in elderly patients. Histopathology is the gold standard in diagnosing SATs, and immunohistochemical staining may be useful in diagnosing tumors with uncertain histopathological features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_300_23","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:00:38Z","timestamp":1715335238000},"page":"807-813","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological analysis of skin adnexal tumors: An experience at a tertiary center"],"prefix":"10.4103","volume":"67","author":[{"given":"Gokhan","family":"Sahin","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ondokuz Mayis University, Medicine Faculty, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Koc Sahin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Samsun Education and Research Hospital, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"R2-20241206","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/jcp.2006.040337","article-title":"Skin adnexal neoplasms--part 1:An approach to tumours of the pilosebaceous unit","volume":"60","author":"Alsaad","year":"2007","journal-title":"J Clin Pathol"},{"key":"R4-20241206","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.humpath.2015.12.015","article-title":"Porocarcinomas harbor recurrent HRAS-activating mutations and tumor suppressor inactivating mutations","volume":"51","author":"Harms","year":"2016","journal-title":"Hum Pathol"},{"key":"R6-20241206","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1136\/jmg.2004.025577","article-title":"Genetics of skin appendage neoplasms and related syndromes","volume":"42","author":"Lee","year":"2005","journal-title":"J Med Genet"},{"key":"R7-20241206","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cdip.2007.05.012","article-title":"The use of immunohistochemistry in the differential diagnosis of common epithelial tumours of the skin","volume":"13","author":"Sanders","year":"2007","journal-title":"Curr Diagn Pathol"},{"key":"R10-20241206","first-page":"879","article-title":"Clinicopathological study of 1016 consecutive adnexal skin tumors","volume":"51","author":"Kamyab-Hesari","year":"2013","journal-title":"Acta Med Iran"},{"key":"R11-20241206","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4103\/0378-6323.44339","article-title":"A clinicopathologic study of skin appendageal tumors","volume":"74","author":"Nair","year":"2008","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R12-20241206","first-page":"2173427","article-title":"Histomorphological and immunohistochemical reappraisal of cutaneous adnexal tumours:A hospital based study","author":"Shukla","year":"2016","journal-title":"Scientifica (Cairo)"},{"key":"R13-20241206","first-page":"FC07","article-title":"Case series of skin adnexal tumours","volume":"8","author":"Rajalakshmi","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"R14-20241206","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3906\/sag-2002-126","article-title":"Are clinicians successful in diagnosing cutaneous adnexal tumors?A retrospective, clinicopathological study","volume":"50","author":"Aslan Kayiran","year":"2020","journal-title":"Turk J Med Sci"},{"key":"R15-20241206","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/1596-3519.55691","article-title":"Adnexal skin tumors in Zaria, Nigeria","volume":"7","author":"Samaila","year":"2008","journal-title":"Ann Afr Med"},{"key":"R16-20241206","doi-asserted-by":"crossref","first-page":"543756","DOI":"10.1155\/2014\/543756","article-title":"Histopathological study of skin adnexal tumours-institutional study in South India","volume":"2014","author":"Sharma","year":"2014","journal-title":"J Skin Cancer"},{"key":"R17-20241206","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4103\/amhsr.amhsr_339_14","article-title":"Adnexal tumors of skin:An experience at a tertiary care center at Delhi","volume":"6","author":"Pujani","year":"2016","journal-title":"Ann Med Health Sci Res"},{"key":"R18-20241206","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4103\/ijd.IJD_380_16","article-title":"Histopathological analysis of skin adnexal tumors:A three year study of 110 cases at a tertiary care center","volume":"62","author":"Kaur","year":"2017","journal-title":"Indian J Dermatol"},{"key":"R19-20241206","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1001\/archdermatol.2011.229","article-title":"Rare tumors through the looking glass:An examination of malignant cutaneous adnexal tumors","volume":"147","author":"Martinez","year":"2011","journal-title":"Arch Dermatol"},{"key":"R22-20241206","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-0028-1109145","article-title":"Pilomatrixom der okul\u00e4ren Adnexe:Klinische und histologische Aufarbeitung von 13 F\u00e4llen [Pilomatrixoma of the ocular adnexae:Clinical and histologic analysis (13 cases)","volume":"226","author":"Herwig","year":"2009","journal-title":"Klin Monbl Augenheilkd"},{"key":"R23-20241206","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaad.2009.04.058","article-title":"Sebaceous lesions and their associated syndromes:Part I","volume":"61","author":"Eisen","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"R24-20241206","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/2000656X.2016.1147741","article-title":"Malignant melanoma arising in sebaceous naevus (of Jadassohn):A case report","volume":"50","author":"Robinson","year":"2016","journal-title":"J Plast Surg Hand Surg"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_300_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:39:56Z","timestamp":1787837996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_300_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_300_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,10]]},"assertion":[{"value":"2023-04-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}