{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:25:58Z","timestamp":1783416358829,"version":"3.54.6"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid neoplasm that poses diagnostic difficulty on preoperative fine-needle aspiration (FNA) cytology. In this retrospective study, eight cases diagnosed as NIFTP on histopathology between January 2019 and January 2022 were retrieved from the pathology department, and their corresponding FNA cytology smears were reviewed to assess cytomorphological features. The most frequent cytological findings observed in the current study were architectural abnormalities, predominantly crowded cell clusters with a microfollicular pattern. Nuclear features included nuclear overlapping and enlargement, eccentric nucleoli, irregular nuclear membranes, pale chromatin, nuclear grooves, and elongated nuclear contours. Intra-nuclear cytoplasmic inclusions were not identified in any of the cases. On cytological categorization, most cases were reported as suspicious for follicular neoplasm. These findings indicate that while certain architectural and nuclear features are consistently observed in NIFTP on cytology, they are not specific enough to allow a definitive preoperative diagnosis. Identification of NIFTP on FNA cytology therefore remains challenging, emphasizing the need for cautious interpretation and histopathological correlation.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_303_22","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:24:56Z","timestamp":1782858296000},"page":"361-365","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Non-invasive follicular thyroid neoplasm with papillary like nuclear feature (NIFTP) a case series on cytomorphological analysis"],"prefix":"10.4103","volume":"69","author":[{"given":"R","family":"Rejla","sequence":"first","affiliation":[{"name":"Bhaarath Medical College and Hospital [Bharath Institute of Higher Education and Research (BIHER)], Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sheeja","sequence":"additional","affiliation":[{"name":"Department of Pathology, Government Medical College, Kottayam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Thambi","sequence":"additional","affiliation":[{"name":"Epsom and St Helier\u2019s NHS Trust, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sankar","sequence":"additional","affiliation":[{"name":"DDRC Agilus Diagnostics, Ernakulam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"R1-20260707","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/cncy.21910","article-title":"Identification of distinct cytomorphologic features in the diagnosis of NIFTP at the time of preoperative FNA: Implications for patient management","volume":"125","author":"Chandler","year":"2017","journal-title":"Cancer Cytopathol"},{"key":"R2-20260707","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/cncy.21907","article-title":"Amodified reporting approach for thyroid FNA in the NIFTP era: A 1-year institutional experience","volume":"125","author":"Mito","year":"2017","journal-title":"Cancer Cytopathol"},{"key":"R3-20260707","first-page":"137","article-title":"WHO Classification of Tumors of Endocrine Organs. 5th ed","author":"Lloyd","year":"2022","journal-title":"International Agency for Research on Cancer, Lyon, France"},{"key":"R4-20260707","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/j.pathol.2018.12.199","article-title":"Histo-cyto correlation of NIFTP\u2014A local experience","volume":"51","author":"Fernando","year":"2019","journal-title":"Pathology"},{"key":"R5-20260707","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/dc.24309","article-title":"Cytologic and clinical features of NIFTP: Can we diagnose based on preoperative fine-needle aspiration","volume":"47","author":"Yan","year":"2019","journal-title":"Diagn Cytopathol"},{"key":"R6-20260707","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/cncy.21777","article-title":"Young investigator challenge: The morphologic analysis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on liquid-based cytology: Some insights into their identification","volume":"124","author":"Bizzarro","year":"2016","journal-title":"Cancer Cytopathol"},{"key":"R7-20260707","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.humpath.2016.03.014","article-title":"Cytological features of \u201cnoninvasive follicular thyroid neoplasm with papillary-like nuclear features\u201dand their correlation with tumor histology","volume":"54","author":"Maletta","year":"2016","journal-title":"Hum Pathol"},{"key":"R8-20260707","first-page":"1039","article-title":"The 2023 bethesda system for reporting thyroid cytopathology","volume":"33","author":"Ali","year":"2023","journal-title":"Thyroid"},{"key":"R9-20260707","first-page":"479","article-title":"Non-invasive follicular thyroid neoplasm with papillary-like nuclear features is not a cytological diagnosis, but it influences cytological diagnosis outcomes: A systematic review and meta-analysis","volume":"65","author":"Haaga","year":"2021","journal-title":"Acta Cytol"},{"key":"R10-20260707","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4103\/joc.joc_192_21","article-title":"Cytological features of non-invasive follicular thyroid tumor with papillary-like nuclear features and correlation with histopathology","volume":"40","author":"Amita","year":"2023","journal-title":"J Cytol"},{"key":"R11-20260707","first-page":"152345","article-title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: Prevalence, cytology-histopathology correlation, and molecular and ultrasonographic profile","volume":"68","author":"Xu","year":"2024","journal-title":"Ann Diagn Pathol"},{"key":"R12-20260707","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1089\/thy.2023.0035","article-title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: Implications for risk of malignancy and cytology","volume":"33","author":"Alzumaili","year":"2023","journal-title":"Thyroid"}],"container-title":["Indian Journal of Pathology and 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