{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:12Z","timestamp":1787070912773,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A diagnosis of synchronous tumors is always questionable when they show similar histology. We present a case of synchronous tumors, i.e. melanoma (MM) arising from the scalp and angiosarcoma (AS) from the cheek in a patient of Xeroderma pigmentosum (XP). The presence of melanin in AS of the cheek led to a differential diagnosis and a possibility of transdifferentiation of malignant melanoma in the first instance. Immunohistochemistry (IHC) was negative for melanoma markers (Melan A, SOX-10 &amp; S 100) and positive for vascular markers (ERG, CD31 &amp; CD34) ruling out transdifferentiation and concluding the cheek swelling as angiosarcoma. The presence of non-cutaneous malignancies is rare in XP and the presence of MM in a nearby site and the melanin pigment in the cutaneous malignancy mislead the diagnosis. The morphology of the tumor was the key which led to the further workup of the case.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_324_24","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T09:24:13Z","timestamp":1725269053000},"page":"616-619","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous multiple primary malignancies or transdifferentiation?\u2014A diagnostic challenge in a case of Xeroderma pigmentosum"],"prefix":"10.4103","volume":"68","author":[{"given":"Sandhyarani M.","family":"Kanna","sequence":"first","affiliation":[{"name":"Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Dayananda Sagar University, Ramanagara, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Sandeepa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Dayananda Sagar University, Ramanagara, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. N.","family":"Mukund","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Dayananda Sagar University, Ramanagara, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nirupama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Dayananda Sagar University, Ramanagara, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. N.","family":"Bhargavi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Dayananda Sagar University, Ramanagara, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Minal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Dayananda Sagar University, Ramanagara, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"R1-20251031","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.3390\/diagnostics12081940","article-title":"Synchronous\/metachronous multiple primary malignancies:Review of associated risk factors","volume":"12","author":"Pan","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"R2-20251031","first-page":"52","article-title":"Cancer stem cells and tumor transdifferentiation:Implications for novel therapeutic strategies","volume":"2","author":"Shekhani","year":"2013","journal-title":"Am J Stem Cells"},{"key":"R3-20251031","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1365-2559.2000.00894.x","article-title":"Morphological and immunophenotypic variations in malignant melanoma","volume":"36","author":"Banerjee","year":"2000","journal-title":"Histopathology"},{"key":"R4-20251031","first-page":"90","article-title":"Two unusual tumours in a patient of xeroderma pigmentosum:Angiosarcoma and basosquamous carcinoma","volume":"2","author":"Shams","year":"2013","journal-title":"J Islamabad Med Dent Coll"},{"key":"R5-20251031","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2559.1992.tb00370.x","article-title":"Angiosarcoma complicating xeroderma pigmentosum","volume":"21","author":"Leake","year":"1992","journal-title":"Histopathology"},{"key":"R6-20251031","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1365-2133.1999.02947.x","article-title":"Angiosarcoma of head and neck associated with xeroderma pigmentosum variant","volume":"141","author":"De Silva","year":"1999","journal-title":"Br J Dermatol"},{"key":"R7-20251031","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1067\/mjd.2000.101883","article-title":"Mast cells in an angiosarcoma complicating xeroderma pigmentosum in a 13 year old girl","volume":"43","author":"Ludolph-Hauser","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"R8-20251031","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/pho.21.1.23.26","article-title":"Cutaneous angiosarcoma in a patient with xeroderma pigmentosum","volume":"21","author":"Marcon","year":"2004","journal-title":"Pediatr Hematol Oncol"},{"key":"R9-20251031","doi-asserted-by":"crossref","first-page":"504","DOI":"10.4103\/0377-4929.43741","article-title":"Cutaneous angiosarcoma in a patient with xeroderma pigmentosum","volume":"51","author":"Arora","year":"2008","journal-title":"Indian J Pathol Microbiol"},{"key":"R10-20251031","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/dermatopathology8030040","article-title":"Aberrant expression of immunohistochemical markers in malignant melanoma:A review","volume":"8","author":"Saliba","year":"2021","journal-title":"Dermatopathology (Basel)"},{"key":"R11-20251031","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/cup.13857","article-title":"Angiosarcomatous transdifferentiation of metastatic melanoma","volume":"47","author":"Kilsdonk","year":"2020","journal-title":"J Cutan Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_324_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:48Z","timestamp":1787067528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_324_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_324_24","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"2024-04-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}