{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:21:31Z","timestamp":1788391291016,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lymphoma of the prostate is rare whether it is primary extranodal lymphoma or secondary involvement of the prostate by primary lymphoma elsewhere. Of all the lymphomas of the prostate, primary lymphomas of the prostrate are very rare. Although less frequent, it should be a differential diagnosis when evaluating prostate tumors. Here, we report a case of a 61-year-old man who presented with hematuria with clot retention. A cystoscopy with clot removal and transurethral resection of the prostate (TURP) was performed. This biopsy was sent for histopathological examination at an external center, where a diagnosis of benign prostatic hyperplasia was given. Fifteen days later, the patient presented with hematuria again. On examination, clots were present in the bladder. There was significant prostatomegaly. A re-resection of the prostate was performed and sent for another review to us. The biopsy was reported as high-grade round cell neoplasm, most likely lymphoma. Immunohistochemistry (IHC) was recommended for confirmation. Tumor cells showed immunoreactivity for CD20, B-cell Lymphoma (BCL)-2, BCL-6, Myelocytomatosis (c-Myc), and multiple myeloma 1 (MUM1). Cluster Differentiation (CD)10 was negative. Kiel-67 was high. A final diagnosis of double-expressor diffuse large B-cell lymphoma (DLBCL) of non-germinal center type was made. We share this case to emphasize the fact that primary lymphoma of the prostate is primarily a histopathological diagnosis as the clinical presentation is not unique. Owing to its rarity, the clinical and histopathological suspicion is low. Hence, keeping the differential in mind while evaluating prostate biopsy is beneficial in a timely diagnosis of the entity as the management of prostatic carcinoma and lymphoma is different.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_325_23","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T13:34:47Z","timestamp":1724938487000},"page":"939-943","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate"],"prefix":"10.4103","volume":"67","author":[{"given":"Richa","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pathology, Haroti Diagnostic Centre, Kota, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Urology, Kota Heart Institute and Superspeciality Hospital, Kota, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Gangoli","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Cytelabs, Cytecare Cancer Hospitals, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"R1-20241206","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<732::AID-CNCR15>3.0.CO;2-T","article-title":"Malignant lymphoma involving the prostate. Report of 62 cases","volume":"83","author":"Bostwick","year":"1998","journal-title":"Cancer"},{"key":"R2-20241206","article-title":"A case report of primary prostate intravascular large B cell lymphoma presenting as prostatic hyperplasia","volume":"98","author":"Zhu","year":"2019","journal-title":"Medicine (United States)"},{"key":"R3-20241206","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ajur.2019.11.002","article-title":"Primary lymphomas of the genitourinary tract:A population-based study","volume":"7","author":"Palumbo","year":"2020","journal-title":"Asian J Urol"},{"key":"R4-20241206","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/01.pas.0000153122.65138.b1","article-title":"Incidental and concurrent malignant lymphomas discovered at the time of prostatectomy and prostate biopsy:A study of 29 cases","volume":"29","author":"Chu","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"R6-20241206","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000225262","article-title":"An autopsy study of the metastatic patterns of human leukemias","volume":"35","author":"Viadana","year":"1978","journal-title":"Oncology"},{"key":"R7-20241206","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1590\/S1677-55382004000500011","article-title":"Primary lymphoma of the prostate:A rare cause of urinary obstruction","volume":"30","author":"Antunes","year":"2004","journal-title":"Int Braz J Urol"},{"key":"R8-20241206","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1002\/1097-0142(19851215)56:12<2932::AID-CNCR2820561234>3.0.CO;2-H","article-title":"Malignant lymphomas involving the prostate. A study of 13 cases","volume":"56","author":"Bostwick","year":"1985","journal-title":"Cancer"},{"key":"R9-20241206","doi-asserted-by":"crossref","first-page":"132","DOI":"10.14740\/wjon1055w","article-title":"Prostatic lymphoma masquerading as urinary retention and hematuria with review of literature","volume":"8","author":"Tamang","year":"2017","journal-title":"World J Oncol"},{"key":"R10-20241206","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3892\/ol.2014.2829","article-title":"Primary non-Hodgkin's lymphoma of the prostate with intractable hematuria:A case report and review of the literature","volume":"9","author":"Hu","year":"2015","journal-title":"Oncol Lett"},{"key":"R11-20241206","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/his.14045","article-title":"Exclusive B-cell phenotype of primary prostatic lymphomas:A potential role of chronic prostatitis","volume":"76","author":"P\u00e9ricart","year":"2020","journal-title":"Histopathology"},{"key":"R12-20241206","doi-asserted-by":"crossref","first-page":"102195","DOI":"10.1016\/j.eucr.2022.102195","article-title":"Primary follicular lymphoma of the prostate presenting with elevated PSA and a PI-RADS 3 lesion on MRI:A case report","volume":"45","author":"Jia","year":"2022","journal-title":"Urol Case Rep"},{"key":"R13-20241206","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0090-4295(88)90241-5","article-title":"Primary non-Hodgkin lymphoma of prostate","volume":"32","author":"Kerbl","year":"1988","journal-title":"Urology"},{"key":"R14-20241206","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/0377-4929.59238","article-title":"Primary diffuse large B-cell lymphoma of the prostate presenting as urinary retention","volume":"53","author":"Kini","year":"2010","journal-title":"Indian J Pathol Microbiol"},{"key":"R15-20241206","first-page":"456","article-title":"Primary lymphomas of the prostate:Two case reports and a review of the literature","volume":"16","author":"Wang","year":"2012","journal-title":"Contemp Oncol"},{"key":"R16-20241206","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s002770050216","article-title":"Chronic lymphocytic leukemia presenting as acute urinary retention due to leukemic infiltration of the prostate","volume":"73","author":"Benekli","year":"1996","journal-title":"Ann Hematol"},{"key":"R17-20241206","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1471-2407-4-95","article-title":"An unusual pathological finding of chronic lymphocitic leukemia and adenocarcinoma of the prostate after transurethral resection for complete urinary retention:Case report","volume":"4","author":"Ballario","year":"2004","journal-title":"BMC Cancer"},{"key":"R18-20241206","doi-asserted-by":"crossref","first-page":"2058738419863217","DOI":"10.1177\/2058738419863217","article-title":"Primary prostate lymphoma:A case report and literature review","volume":"33","author":"Wang","year":"2019","journal-title":"Int J Immunopathol Pharmacol"},{"key":"R19-20241206","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1590\/S1677-55382006000100010","article-title":"Primary diffuse large B-cell lymphoma of the prostate in a young patient","volume":"32","author":"Alvarez","year":"2006","journal-title":"Int Braz J Urol"},{"key":"R20-20241206","first-page":"86","article-title":"Primary prostatic lymphoma with components of both diffuse large B-cell lymphoma (DLBCL) and MALT lymphoma","volume":"16","author":"Petrakis","year":"2012","journal-title":"Hippokratia"},{"key":"R22-20241206","doi-asserted-by":"crossref","first-page":"5494","DOI":"10.1158\/1078-0432.CCR-09-0113","article-title":"A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy","volume":"15","author":"Choi","year":"2009","journal-title":"Clin Cancer Res"},{"key":"R23-20241206","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1002\/cncr.31646","article-title":"Double hit and double expressors in lymphoma:Definition and treatment","volume":"124","author":"Riedell","year":"2018","journal-title":"Cancer"},{"key":"R24-20241206","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000457117","article-title":"Primary extranodal difuse large B-cell lymphoma of the prostate:A case report","volume":"10","author":"Ezekwudo","year":"2017","journal-title":"Case Rep Oncol"},{"key":"R25-20241206","first-page":"412","article-title":"Primary prostate lymphoma managed with combined modality treatment:A case report","volume":"16","author":"Jafari","year":"2019","journal-title":"Urol 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