{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:27:20Z","timestamp":1787761640704,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>IgA anti-tissue transglutaminase-2 antibody (anti-TG2Ab) deposits in intestinal and extraintestinal organs have been used to link the respective pathological changes in these organs with celiac disease (CeD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To know if parts of intestine other than the duodenum, such as esophagus, stomach, and colon, have any pathology related to potential CeD or have mucosal IgA anti-TG2 Ab deposits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>A prospective case\u2013control study conducted from April 2018 to December 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Nine patients with potential CeD and 27 age- and gender-matched patients with irritable bowel syndrome were recruited as cases and controls, respectively. Mucosal biopsies were collected from esophagus, stomach, duodenum, and rectosigmoid regions, histological changes were evaluated, and IgA anti-TG2 Ab deposits were analyzed in these regions by two-color immunohistochemical staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistics:<\/jats:title>\n                    <jats:p>Data were analyzed using statistical software Stata 14.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No distinct difference in mucosal lymphocytosis were identified between biopsies of patients with potential CeD and controls at the following sites: esophagus (11.1% vs 0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.079), stomach (14.3% vs 7.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.590), and rectum (20% vs 0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.067). Co-localized IgA anti-TG2Ab deposits were observed more in potential CeD than in controls at esophagus 22.2% (2\/9) vs 0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012; stomach 66.7% (6\/9) vs 11.5% (3\/26),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001; and duodenum 66.7% (6\/9) vs 0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 but not at rectum 0% (0\/4) vs 0% (0\/25).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although histological changes are not distinct, a subset of subjects with potential CeD has pan-intestinal involvement other than in the duodenum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_354_22","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T01:16:19Z","timestamp":1675127779000},"page":"24-30","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Gastrointestinal tract involvement in patients with potential celiac disease beyond the small intestine"],"prefix":"10.4103","volume":"66","author":[{"given":"Ashish","family":"Chauhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasenjit","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahender Singh","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimlee","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Banyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajiha","family":"Mehtab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Makharia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240829","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: Systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R2-6-20240829","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41575-021-00552-z","article-title":"The global burden of coeliac disease: Opportunities and challenges","volume":"19","author":"Makharia","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"R3-6-20240829","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cgh.2015.10.024","article-title":"Features and progression of potential celiac disease in adults","volume":"14","author":"Volta","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R4-6-20240829","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ajg.2014.77","article-title":"Potential celiac children: 9-Year follow-up on a gluten-containing diet","volume":"109","author":"Auricchio","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"R5-6-20240829","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1053\/j.gastro.2019.04.004","article-title":"Progression of celiac disease in children with antibodies against tissue transglutaminase and normal duodenal architecture","volume":"157","author":"Auricchio","year":"2019","journal-title":"Gastroenterology"},{"key":"R6-6-20240829","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cgh.2010.09.006","article-title":"Natural history of potential celiac disease in children","volume":"9","author":"Tosco","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R7-6-20240829","doi-asserted-by":"crossref","first-page":"e21281","DOI":"10.1371\/journal.pone.0021281","article-title":"Potential celiac patients: A model of celiac disease pathogenesis","volume":"6","author":"Sperandeo","year":"2011","journal-title":"PloS One"},{"key":"R8-6-20240829","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(98)05342-2","article-title":"Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia","volume":"352","author":"Hadjivassiliou","year":"1998","journal-title":"Lancet"},{"key":"R9-6-20240829","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s12664-019-01006-w","article-title":"The spectrum of clinical and subclinical endocrinopathies in treatment-na\u00efve patients with celiac disease","volume":"38","author":"Gupta","year":"2019","journal-title":"Indian J Gastroenterol"},{"key":"R10-6-20240829","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1365-4632.2007.03214.x","article-title":"Clinical, pathologic, and immunopathologic features of dermatitis herpetiformis: Review of the Mayo Clinic experience","volume":"46","author":"Alonso-Llamazares","year":"2007","journal-title":"Int J Dermatol"},{"key":"R12-6-20240829","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease","volume":"54","author":"Husby","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R13-6-20240829","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1155\/2001\/367832","article-title":"The updated Sydney system: Classification and grading of gastritis as the basis of diagnosis and treatment","volume":"15","author":"Stolte","year":"2001","journal-title":"Can J Gastroenterol"},{"key":"R14-6-20240829","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.humpath.2004.12.008","article-title":"Staging and grading of chronic gastritis","volume":"36","author":"Rugge","year":"2005","journal-title":"Hum Pathol"},{"key":"R15-6-20240829","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.crohns.2013.06.001","article-title":"European consensus on the histopathology of inflammatory bowel disease","volume":"7","author":"Magro","year":"2013","journal-title":"J Crohns Colitis"},{"key":"R16-6-20240829","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.humpath.2009.07.016","article-title":"Development of consensus guidelines for the histologic recognition of microscopic esophagitis in patients with gastroesophageal reflux disease: The Esohisto project","volume":"41","author":"Fiocca","year":"2010","journal-title":"Hum Pathol"},{"key":"R17-6-20240829","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","article-title":"The histopathology of coeliac disease: Time for a standardized report scheme for pathologists","volume":"11","author":"Oberhuber","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R18-6-20240829","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/2050640616689525","article-title":"Guidelines on eosinophilic esophagitis: Evidence-based statements and recommendations for diagnosis and management in children and adults","volume":"5","author":"Lucendo","year":"2017","journal-title":"United Eur Gastroenterol J"},{"key":"R19-6-20240829","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ajg.2013.71","article-title":"American College of Gastroenterology. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE)","volume":"108","author":"Dellon","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"R20-6-20240829","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12664-017-0789-6","article-title":"Prevalence of eosinophilic esophagitis in patients with gastroesophageal reflux symptoms: A cross-sectional study from a tertiary care hospital in North India","volume":"36","author":"Baruah","year":"2017","journal-title":"Indian J Gastroenterol"},{"key":"R21-6-20240829","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1309\/7LABLGY08UEM3H26","article-title":"Lymphocytic esophagitis: A histologic subset of chronic esophagitis","volume":"125","author":"Rubio","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"R22-6-20240829","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1046\/j.1365-2036.2002.01301.x","article-title":"Gastric mucosal atrophy: Interobserver consistency using new criteria for classification and grading: Classification of gastric mucosal atrophy","volume":"16","author":"Rugge","year":"2002","journal-title":"Aliment PharmacolTher"},{"key":"R23-6-20240829","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1053\/j.gastro.2011.02.003","article-title":"Microscopic colitis","volume":"140","author":"Pardi","year":"2011","journal-title":"Gastroenterology"},{"key":"R24-6-20240829","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/gut.43.5.629","article-title":"Lymphocytic colitis: Clinical presentation and long term course","volume":"43","author":"Mullhaupt","year":"1998","journal-title":"Gut"},{"key":"R25-6-20240829","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fmed.2017.00261","article-title":"Eosinophilic gastrointestinal disorders pathology","volume":"4","author":"Collins","year":"2018","journal-title":"Front Med"},{"key":"R27-6-20240829","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/jclinpath-2020-206735","article-title":"Liver involvement in patients with coeliac disease: Proof of causality using IgA\/anti-TG2 colocalisation techniques","volume":"74","author":"Dutta","year":"2021","journal-title":"J Clin Pathol"},{"key":"R28-6-20240829","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3109\/00365521.2013.777470","article-title":"Prevalence and natural history of potential celiac disease in adult patients","volume":"48","author":"Biagi","year":"2013","journal-title":"Scand J Gastroenterol"},{"key":"R29-6-20240829","first-page":"9","article-title":"Beyond the intestinal celiac mucosa: Diagnostic role of Anti-TG2 deposits, a systematic review","volume":"1","author":"Gatti","year":"2014","journal-title":"Front Med (Laussane"},{"key":"R30-6-20240829","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/MPG.0b013e3181677067","article-title":"Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy","volume":"47","author":"Tosco","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R31-6-20240829","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1309\/D3PCF6D6YYMQRX9A","article-title":"Lymphocytic esophagitisa chronic or recurring pattern of esophagitis resembling allergic contact dermatitis","volume":"130","author":"Purdy","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"R32-6-20240829","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/apt.16621","article-title":"Lymphocytic gastritis and its relationships with other gastrointestinal disorders","volume":"54","author":"Genta","year":"2021","journal-title":"Aliment PharmacolTher"},{"key":"R33-6-20240829","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/0046-8177(90)90144-T","article-title":"Colonic lymphocytosis in patients with celiac sprue","volume":"21","author":"Wolber","year":"1990","journal-title":"Hum Pathol"},{"key":"R34-6-20240829","doi-asserted-by":"crossref","first-page":"110\u20131","DOI":"10.1016\/S0016-5085(21)01011-8","article-title":"537 endoscopy and systematic biopsy of patients with chronic gastrointestinal symptoms leads to high discovery rate of patients who meet histologic criteria for eosinophilic gastritis and\/or eosinophilic duodenitis","volume":"160","author":"Talley","year":"2021","journal-title":"Gastroenterology"},{"key":"R35-6-20240829","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH665>3.0.CO;2-O","article-title":"Double immunofluorescence labelling of routinely processed paraffin sections","volume":"191","author":"Mason","year":"2000","journal-title":"J Pathol"},{"key":"R36-6-20240829","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1354\/vp.42-4-405","article-title":"Technical aspects of immunohistochemistry","volume":"42","author":"Ramos-Vara","year":"2005","journal-title":"Vet Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_354_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:02:24Z","timestamp":1787760144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_354_22"}},"subtitle":["An early proof with IgA anti-tissue transglutaminase-2 antibody deposits"],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_354_22","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}