{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:31:24Z","timestamp":1787772684683,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Epstein-Barr virus (EBV) is a lymphotropic virus that causes diseases ranging from a flu-like illness called infectious mononucleosis to nasopharyngeal carcinoma, Burkitt\u2019s lymphoma, and central nervous system (CNS) infection. Detection of EBV DNA is usually done using whole blood samples taken from the patients. We undertook the detection of EBV in blood, cerebrospinal fluid (CSF), and saliva by real-time quantitative PCR in two patients, one with a history of nasopharyngeal carcinoma, and the other having a case of viral encephalitis. EBV was detected only in saliva, whole blood in both patients, and CSF in the second case tested negative. This case series illustrates the importance of testing for EBV DNAemia in saliva by real-time polymerase chain reaction (PCR) to rule in a diagnosis of EBV.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_356_23","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T13:31:54Z","timestamp":1724938314000},"page":"208-211","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients"],"prefix":"10.4103","volume":"68","author":[{"given":"Nanditha","family":"Srinivasan","sequence":"first","affiliation":[{"name":"Undergraduate MBBS Student, Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Barani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Manickavasagan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma","family":"Srikanth","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"R1-20250411","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/0255-0857.81777","article-title":"Comparison of a conventional polymerase chain reaction with real-time polymerase chain reaction for the detection of neurotropic viruses in cerebrospinal fluid samples","volume":"29","author":"Ramamurthy","year":"2011","journal-title":"Indian J Med Microbiol"},{"key":"R2-20250411","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.oraloncology.2011.06.507","article-title":"Salivary Epstein-Barr virus DNA level in patients with nasopharyngeal carcinoma following radiotherapy","volume":"47","author":"Pow","year":"2011","journal-title":"Oral Oncol"},{"key":"R3-20250411","doi-asserted-by":"crossref","first-page":"757644","DOI":"10.3389\/fmolb.2021.757644","article-title":"Prognostic value of oral Epstein-Barr virus DNA load in locoregionally advanced nasopharyngeal carcinoma","volume":"8","author":"He","year":"2021","journal-title":"Front Mol Biosci"},{"key":"R4-20250411","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/viro.1999.9619","article-title":"Detection of Epstein-Barr virus (EBV) in hepatocellular carcinoma tissue:A novel EBV latency characterized by the absence of EBV-encoded small RNA expression","volume":"256","author":"Sugawara","year":"1999","journal-title":"Virology"},{"key":"R5-20250411","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1590\/0074-0276140049","article-title":"Assessment of immunological changes in Epstein-Barr virus co-infection in Egyptian chronic HCV patients","volume":"109","author":"Shoman","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"R6-20250411","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1084\/jem.20071030","article-title":"Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain","volume":"204","author":"Serafini","year":"2007","journal-title":"J Exp Med"},{"key":"R7-20250411","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1038\/cti.2014.25","article-title":"Epstein-Barr virus and multiple sclerosis:Potential opportunities for immunotherapy","volume":"3","author":"Pender","year":"2014","journal-title":"Clin Transl Immunology"},{"key":"R8-20250411","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.3390\/jcm10214995","article-title":"Epstein-Barr virus in salivary samples from systemic lupus erythematosus patients with oral lesions","volume":"10","author":"Buonavoglia","year":"2021","journal-title":"J Clin Med"},{"key":"R9-20250411","first-page":"95","article-title":"Epstein\u2013Barr virus DNAemia and co-occurrence with cytomegalovirus DNAemia in postrenal transplant recipients from a tertiary care center. Indian J","volume":"12","author":"Barani","year":"2018","journal-title":"Transplant"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_356_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:08:51Z","timestamp":1787771331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_356_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_356_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"2023-05-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}