{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:28:18Z","timestamp":1787772498397,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Hobnail variant of papillary thyroid carcinoma (HV-PTC) is an unusual entity recently included in WHO classification of endocrine tumors (2017) and proposed as an aggressive variant of PTC. Compared to patients of classical counterparts, HV-PTC frequently has extrathyroidal extension, exhibits nodal or distant metastasis, and responds poorly to radioiodine treatment, leading to increased mortality. We hereby describe the cytohistological and immunohistochemical features of a metastatic HV-PTC in 55-year-old male, previously diagnosed as poorly differentiated papillary thyroid carcinoma in thyroidectomy specimen. Five years after total thyroidectomy with radical neck dissection the patient presented with gross pleural effusion showing multiple lung parenchymal and pleural based lesions with complete collapse of lung on computed tomography scan. The conventional cytology of pleural fluid showed dyscohesive cells arranged in micropapillary form gave the suggestion of metastatic papillary carcinoma. But the cell block preparation highlighted &gt;30% hobnail cells arranged in micropapillary pattern showing increased atypical mitosis and occasional pseudoinclusions. Supplemented with immunohistochemistry (CK19, TTF-1, and p53), final diagnosis HV-PTC was made.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_381_20","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:11:46Z","timestamp":1717042306000},"page":"358-361","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Metastatic hobnail variant of papillary thyroid carcinoma"],"prefix":"10.4103","volume":"64","author":[{"given":"Debahuti","family":"Mohapatra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Agrawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-24-20240829","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/PAP.0000000000000184","article-title":"Aggressive variants of papillary thyroid carcinoma: Hobnail, tall cell, columnar, and solid","volume":"25","author":"Nath","year":"2018","journal-title":"Adv Anat Pathol"},{"key":"R3-24-20240829","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.humpath.2012.06.003","article-title":"Papillary thyroid carcinoma with hobnail features: Histopathologic criteria to predict aggressive behavior","volume":"44","author":"Asioli","year":"2013","journal-title":"Hum Pathol"},{"key":"R4-24-20240829","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/PAS.0b013e3181c46677","article-title":"Papillary thyroid carcinoma with prominent hobnail features: A new aggressive variant of moderately differentiated papillary carcinoma. A clinicopathologic, immunohistochemical, and molecular study of eight cases","volume":"34","author":"Asioli","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"R5-24-20240829","first-page":"7988","article-title":"Cytologic, clinicopathologic, and molecular features of papillary thyroid carcinoma with prominent hobnail features: 10 case reports and systematic literature review","volume":"8","author":"Lee","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"R6-24-20240829","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1089\/thy.2013.0573","article-title":"Hobnail variant of papillary thyroid carcinoma: An institutional case series and molecular profile","volume":"24","author":"Lubitz","year":"2014","journal-title":"Thyroid"},{"key":"R7-24-20240829","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12022-017-9502-7","article-title":"Hobnail variant of papillary thyroid carcinoma: A literature review","volume":"28","author":"Ambrosi","year":"2017","journal-title":"Endocr Pathol"},{"key":"R8-24-20240829","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/cyt.12076","article-title":"Diffuse sclerosing variant of papillary thyroid carcinoma: A study of fine needle aspiration cytology in 20 patients","volume":"25","author":"Takagi","year":"2014","journal-title":"Cytopathology"},{"key":"R9-24-20240829","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/dc.23723","article-title":"Hobnail variant of papillary thyroid carcinoma: A case with an unusual presentation","volume":"45","author":"Lilo","year":"2017","journal-title":"Diagn Cytopathol"},{"key":"R10-24-20240829","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/PAS.0000000000000793","article-title":"Hobnail Variant of Papillary Thyroid Carcinoma: Clinicopathologic and molecular evidence of progression to undifferentiated carcinoma in 2 cases","volume":"41","author":"Cameselle-Teijeiro","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"R11-24-20240829","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/ERC-16-0546","article-title":"Somatic mutation profiling of hobnail variant of papillary thyroid carcinoma","volume":"24","author":"Morandi","year":"2017","journal-title":"Endocr Relat Cancer"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_381_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:49:50Z","timestamp":1787770190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_381_20"}},"subtitle":["A diagnostic challenge in cell block preparation"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_381_20","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}