{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:29:59Z","timestamp":1787070599392,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"\n \n \n Pediatric melanomas are uncommon and sometimes arise in the background of giant congenital melanocytic nevus (GCMN). A 1-year-old girl was born with GCMN affecting her left half of the face and smaller nodules affecting trunk, hands, and feet. She developed an ulcerated lesion on the left temporoparietal scalp. The lesion showed features of GCMN along with large nests of a tumor composed of round cells with a vesicular nucleus, prominent nucleolus, plentiful mitoses, and areas of necrosis. Immunostaining for desmin, LCA, CD 20, CD 34, CD 99, BCL-2, and FLI1 was negative. Tumor cells showed immunopositivity for S-100 and HMB-45 confirming the diagnosis of melanoma. Immunostaining for\n BRAF V600E<\/jats:italic>\n was negative; however,\n NRAS<\/jats:italic>\n mutation was detected on next-generation sequencing. Unlike adult melanomas\n BRAF<\/jats:italic>\n mutations are rare but\n NRAS<\/jats:italic>\n mutations have been reported in pediatric melanomas. Adjunctive molecular testing will be important to understand the genetic basis of this disease and future targeted therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_38_20","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:11:46Z","timestamp":1717042306000},"page":"402-405","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["NRAS mutant melanoma arising in a giant congenital melanocytic nevus in an infant"],"prefix":"10.4103","volume":"64","author":[{"given":"Neha","family":"Bansal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mou","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttara","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamata Guha","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak K.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-35-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2133.2006.07218.x","article-title":"Melanoma risk in congenital melanocytic naevi: A systematic review","volume":"155","author":"Krengel","year":"2006","journal-title":"Br J Dermatol"},{"key":"R2-35-20240829","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/sj.jid.5700725","article-title":"Chromosomal translocations as a mechanism of BRAF activation in two cases of large congenital melanocytic nevi","volume":"127","author":"Dessars","year":"2007","journal-title":"J Invest Dermatol"},{"key":"R3-35-20240829","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/jid.2014.425","article-title":"The genomic landscape of childhood and adolescent melanoma","volume":"135","author":"Lu","year":"2015","journal-title":"J Invest Dermatol"},{"key":"R4-35-20240829","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0190-9622(79)70009-0","article-title":"Congenital nevocytic nevi and malignant melanomas","volume":"1","author":"Kopf","year":"1979","journal-title":"J Am Acad Dermatol"},{"key":"R5-35-20240829","first-page":"495","article-title":"Congenital melanocytic nevi: Where are we now? 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