{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:55Z","timestamp":1787840335492,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>\n                      Primary central nervous system lymphomas (PCNSLs) are extranodal non-Hodgkin lymphomas confined to the brain, leptomeninges, eyes, or spinal cord without systemic involvement. The main goal of this study is to examine the incorporation of PCNSLs in three distinct \u201cblue books\u201d (WHO Classification of CNS Tumors [WHO-CNS5], WHO Classification of Hematopoietic and Lymphoid Tissues, Revised 4\n                      <jats:sup>th<\/jats:sup>\n                      edition [WHO-HAEM4R], WHO Classification of Hematolymphoid Tumors, 5\n                      <jats:sup>th<\/jats:sup>\n                      edition [beta version] [WHO-HAEM5-Beta]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Fifteen immunocompetent patients diagnosed with PCNSL between 2016 and 2023 were included in this study. WHO-CNS5 and WHO-HAEM4R diagnoses were revised according to the WHO-HAEM5-Beta classification. Fluorescence\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      hybridization (FISH) examination was used to investigate MYC, BCL6, and BCL2 rearrangement in large B-cell lymphomas of immune privileged sites (IP-LBCL) of patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 15 patients diagnosed with PCNSL, 10 (66.6%) had IP-LBCL. The patients had a mean age of 59.43 years, and 9 (60%) were female. The cerebral hemisphere was the most frequent tumor site. No rearrangements were detected in seven cases of IP-LBCL by FISH analysis. No significant correlations were found between the percentage increase in BCL2, BCL6, C-MYC, or MUM-1 expression and overall survival. However, as the percentage of BCL2 expression increased, there was a significant increase in BCL6 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PCNSL is an extranodal non-Hodgkin lymphoma that typically affects older individuals and has a poor prognosis and challenging treatment. In this study, we re-evaluated our cases diagnosed with PCNSL using the three \u201cblue books\u201d and revised the diagnoses according to WHO HAEM5-Beta. The absence of MYC and BCL2 rearrangements supports the diagnosis of IP-LBCL, as determined by FISH analysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_401_24","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T17:00:08Z","timestamp":1755536408000},"page":"730-735","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Primary central nervous system lymphomas in three \u201cblue books\u201d and correlation of recently defined primary large B-cell lymphoma of immune-privileged sites: Single-center experience"],"prefix":"10.4103","volume":"68","author":[{"given":"Onur","family":"Sahin","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irem Guvendir","family":"Bakkaloglu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kartal Dr. L\u00fctfi K\u0131rdar City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Hakan","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Hematology, Biruni University Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Health Sciences, Sultan 2. Abdulhamid Khan Educational and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabire Asl\u0131","family":"Altunbas","sequence":"additional","affiliation":[{"name":"Medical Faculty Student, Faculty of Medicine, Bahcesehir University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"It\u0131r Ebru","family":"Zemheri","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"R4-20251208","doi-asserted-by":"crossref","first-page":"172","DOI":"10.25259\/SNI_307_2023","article-title":"Double-hit and double-expressor primary central nervous system lymphoma:Experience from North India of an infrequent but aggressive variant","volume":"14","author":"Parkhi","year":"2023","journal-title":"Surg Neurol Int"},{"key":"R5-20251208","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1182\/blood.2020008377","article-title":"Primary central nervous system lymphoma","volume":"140","author":"Schaff","year":"2022","journal-title":"Blood"},{"key":"R6-20251208","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.critrevonc.2017.03.019","article-title":"Primary central nervous system lymphoma","volume":"113","author":"Citterio","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"key":"R7-20251208","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours:Lymphoid Neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"R8-20251208","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12288-022-01557-7","article-title":"Demographics, pattern of care and outcomes of primary CNS lymphoma- experience from a Tertiary Care Cancer Center in India","volume":"39","author":"Das","year":"2023","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R9-20251208","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/0028-3886.152658","article-title":"Clinicopathological correlates of primary central nervous system lymphoma:experience from a tertiary care center in South India","volume":"63","author":"Patel","year":"2015","journal-title":"Neurol India"},{"key":"R10-20251208","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/0019-509X.82890","article-title":"Primary central nervous system lymphoma:a study of clinicopathological features and trend in western India","volume":"48","author":"Pasricha","year":"2011","journal-title":"Indian J Cancer"},{"key":"R11-20251208","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1182\/blood.V96.10.3569","article-title":"Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites","volume":"96","author":"Riemersma","year":"2000","journal-title":"Blood"},{"key":"R12-20251208","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00428-019-02698-3","article-title":"Lymphomas arising in immune-privileged sites:\u0130nsights into biology, diagnosis, and pathogenesis","volume":"476","author":"King","year":"2020","journal-title":"Virchows Arch"},{"key":"R13-20251208","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.7150\/thno.54343","article-title":"The immune contexture of primary central nervous system diffuse large B cell lymphoma associates with patient survival and specific cell signaling","volume":"11","author":"Alame","year":"2021","journal-title":"Theranostics"},{"key":"R14-20251208","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/bjh.19238","article-title":"Primary central nervous system marginal zone lymphoma","volume":"204","author":"Flospergher","year":"2024","journal-title":"Br J Haematol"},{"key":"R15-20251208","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3892\/ol.2023.13994","article-title":"Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone Bcell lymphoma:A case report","volume":"26","author":"Fiorentino","year":"2023","journal-title":"Oncol Lett"},{"key":"R16-20251208","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11060-004-3390-7","article-title":"Primary central nervous system lymphomas (PCNSL):MRI features at presentation in 100 patients","volume":"72","author":"K\u00fcker","year":"2005","journal-title":"J Neurooncol"},{"key":"R17-20251208","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/bjh.14073","article-title":"Trends in primary central nervous system lymphoma incidence and survival in the U. 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