{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:25Z","timestamp":1786649665632,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hemoglobinopathies are a common cause of anemia in the northwestern part of India. Although heterozygosity for hemoglobin (Hb) D-Punjab is common, a compound heterozygous state for Hb D-Punjab and beta (\u03b2)-thalassemia is quite rare. Here, we report two family studies in which children inherited defective genes from carrier parents and manifested clinically significant compound heterozygous (Hb D\/\u03b2-thalassemia) and homozygous (\u03b2-thalassemia major) states. This study underscores the growing need to enhance awareness regarding the largely unchanged prevalence of clinically significant hemoglobinopathies. It further highlights the importance of a comprehensive diagnostic approach, including molecular analysis for the identification of rare variants, and emphasizes the significance of premarital and population-based screening.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_432_25","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:36Z","timestamp":1777374276000},"page":"329-331","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Co-inheritance of hemoglobin D-Punjab and beta thalassemia: Familial case study highlighting the clinical relevance and the need for premarital screening"],"prefix":"10.4103","volume":"69","author":[{"given":"Tejasvi","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Purohit","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyaram","family":"Didel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolat S.","family":"Shekhawat","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"R1-20260707","first-page":"704","article-title":"Inherited haemoglobin disorders: an increasing global health problem","volume":"79","author":"Weatherall","year":"2001","journal-title":"Bull World Health Organ"},{"key":"R2-20260707","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1073\/pnas.37.12.775","article-title":"A third hemoglobin associated with hereditary hemolytic anemia","volume":"37","author":"Itano","year":"1951","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R3-20260707","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1590\/S1516-31802012000400008","article-title":"Molecular characterization of haemoglobin D-Punjab traits and clinical-hematological profile of the patients","volume":"130","author":"Pandey","year":"2012","journal-title":"Sao Paulo Med J"},{"key":"R4-20260707","first-page":"507","article-title":"Variants of hemoglobin D Punjab-a retrospective study","volume":"4","author":"Patel","year":"2019","journal-title":"Saudi J Pathol Microbiol"},{"key":"R5-20260707","doi-asserted-by":"crossref","first-page":"90","DOI":"10.24018\/ejmed.2021.3.1.681","article-title":"Hemoglobin D-Punjab homozygotes and double heterozygotes in premarital screening: Case presentations and minireview","volume":"3","author":"Denic","year":"2021","journal-title":"EJMED"},{"key":"R6-20260707","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/0377-4929.59185","article-title":"Detection of Hb variants and hemoglobinopathies in Indian population using HPLC: Report of 2600 cases","volume":"53","author":"Sachdev","year":"2010","journal-title":"Indian J Pathol Microbiol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_432_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:56:40Z","timestamp":1786647400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_432_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_432_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-05-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}