{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:34:11Z","timestamp":1787841251755,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Cervical cancer is the fourth most common cancer in females in the world, mainly caused by persistent human papilloma virus (HPV) infection. Early diagnosis is important to reduce mortality. This study aims to observe the expression of p16, epidermal growth factor receptor (\n EGFR<\/jats:italic>\n ), cluster differentiation 44 (\n CD44<\/jats:italic>\n ), compare with histological grade, and clinical stage in squamous cell carcinoma (SCC) cervix. Sixty-two cases of untreated SCC cervix were included and immunohistochemistry for\n p16, EGFR<\/jats:italic>\n , and\n CD44<\/jats:italic>\n was performed.\n CD44<\/jats:italic>\n expression increased with increasing clinical stage (\n P<\/jats:italic>\n = 0.007). A positive correlation between\n EGFR<\/jats:italic>\n and\n CD44<\/jats:italic>\n expression (\n P<\/jats:italic>\n = 0.001); and\n p16<\/jats:italic>\n and\n EGFR<\/jats:italic>\n expression (\n P<\/jats:italic>\n = 0.015) was observed. No significant association of\n p16<\/jats:italic>\n and\n EGFR<\/jats:italic>\n with clinical stage and of\n p16, EGFR<\/jats:italic>\n , and\n CD44<\/jats:italic>\n with histological types was observed.\n CD44<\/jats:italic>\n expression can aid in staging carcinoma. These results add to growing literature suggesting that HPV interaction changes biology of\n EGFR<\/jats:italic>\n by preventing degradation.\n <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_455_22","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T13:00:11Z","timestamp":1771592411000},"page":"48-53","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The expression of p16, epidermal growth factor receptor and CD44 in squamous cell carcinoma uterine cervix"],"prefix":"10.4103","volume":"69","author":[{"given":"Kanika","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pathology and Obstetrics and Gynaecology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shramana","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Pathology and Obstetrics and Gynaecology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meeta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Obstetrics and Gynaecology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. M.","family":"Mala","sequence":"additional","affiliation":[{"name":"Department of Pathology and Obstetrics and Gynaecology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"R1-20260403","first-page":"394","article-title":"Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"R2-20260403","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/v10120729","article-title":"Cervical cancer screening programs in Europe:The transition towards HPV vaccination and population-based HPV 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