{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:17:42Z","timestamp":1790619462204,"version":"4.1.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    NUT carcinoma is a rare, aggressive, undifferentiated carcinoma characterized by\n                    <jats:italic toggle=\"yes\">NUTM1<\/jats:italic>\n                    gene rearrangement. It was formerly termed NUT midline carcinoma due to its propensity to occur in midline anatomical structures. While initially believed to affect children and young adults predominantly, subsequent research has revealed its capacity to affect individuals of any age, without gender predilection. NUT carcinoma has been included in the 2015 WHO classification of thoracic tumors. NUT carcinoma can be difficult to distinguish from poorly differentiated tumors, often requiring immunohistochemistry (IHC) or molecular studies for diagnosis. The diagnostic immunohistochemical staining for NUT carcinoma is the NUT antibody. NUT carcinoma is usually positive for p63 IHC. Rare instances of p63-negative NUT carcinoma have been documented, particularly in the thoracic region. Here, we present a unique case of p63-negative thoracic NUT carcinoma, emphasizing the potential diagnostic pitfall.\n                  <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_493_24","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T05:00:14Z","timestamp":1749445214000},"page":"865-867","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["p63-negative thoracic NUT carcinoma - A potential diagnostic pitfall"],"prefix":"10.4103","volume":"68","author":[{"given":"K R","family":"Anila","sequence":"first","affiliation":[{"name":"Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Kaviya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Priyakumari","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Jayasree","sequence":"additional","affiliation":[{"name":"Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"R1-20251208","doi-asserted-by":"crossref","first-page":"914031","DOI":"10.3389\/fonc.2022.914031","article-title":"NUT Carcinoma-An underdiagnosed malignancy","volume":"12","author":"Lauer","year":"2022","journal-title":"Front Oncol"},{"key":"R2-20251208","doi-asserted-by":"crossref","first-page":"pkz094","DOI":"10.1093\/jncics\/pkz094","article-title":"An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: Analysis of 124 patients","volume":"4","author":"Chau","year":"2019","journal-title":"JNCI Cancer Spectr"},{"key":"R3-20251208","doi-asserted-by":"crossref","first-page":"860830","DOI":"10.3389\/fonc.2022.860830","article-title":"NUT carcinoma: Clinicopathologic features, molecular genetics and epigenetics","volume":"12","author":"Moreno","year":"2022","journal-title":"Front Oncol"},{"key":"R4-20251208","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/pin.12727","article-title":"NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment","volume":"68","author":"French","year":"2018","journal-title":"Pathol Int"},{"key":"R5-20251208","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13000-020-01053-4","article-title":"P63-negative pulmonary NUT carcinoma arising in the elderly: A case report","volume":"15","author":"Numakura","year":"2020","journal-title":"Diagn Pathol"},{"key":"R6-20251208","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.21037\/tcr-20-1884","article-title":"Advances in the pathogenesis and treatment of nut carcinoma: A narrative review","volume":"9","author":"Wang","year":"2020","journal-title":"Transl Cancer Res"},{"key":"R7-20251208","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/08880018.2017.1363839","article-title":"Pediatric NUT-midline carcinoma: Therapeutic success employing a sarcoma based multimodal approach","volume":"34","author":"Storck","year":"2017","journal-title":"Pediatr Hematol Oncol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_493_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:27Z","timestamp":1787837067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_493_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_493_24","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"2024-06-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}