{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:56:52Z","timestamp":1791997012117,"version":"4.4.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Gall bladder carcinoma is endemic in North India along the Ganges belt. Most of the cases usually present in late stage when prognosis is poor. That mandates a necessity for proper screening in these areas for gall bladder lesions. Tumor markers CA 19-9 and CA 125 have been studied in various GI cancers and may also help in the screening, diagnosis and evaluation of gall bladder carcinoma. Aims: To assess serum CA19-9 and serum CA125 in patients with gall bladder lesions and find out a cut off value for diagnosis of carcinoma gallbladder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Material:<\/jats:title>\n                    <jats:p>Study included 118 cases, with female: male ratio of 4:1. Out of it, 91 (77 %) cases were benign and 27 (23 %) were malignant. Patients' sera was collected and analyzed for CA19-9 and CA 125 by CMIA method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The Mean (SD) value of CA19-9 for benign and malignant cases was found to be 12.86 (17.54) and 625.35(186.52) U\/ml. For CA 125 it was found to be 17.98(13.69) and 239.63(73.72) U\/ml respectively. The difference was statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). When Mean - 2SD value of malignant lesions were taken as cut off a value of CA 19-9 and CA 125 were found be 252.31 U\/ml &amp; 92.19U\/ml respectively, found to be significant to suggest \/diagnose a case of carcinoma gall bladder along with clinicoradiological findings. Taking these value as cut off Sensitivity &amp; Specificity for CA 19-9 and CA 125 in detecting malignant cases were found to be 100% &amp; 98.90% and 100% &amp; 94.50% respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>It is concluded that both serum CA 19-9 and serum CA 125 may act as a good adjunct for diagnosis of cases of carcinoma gallbladder along with imaging studies. However, changes in CA19-9 are more significant than CA 125.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_494_19","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:04:25Z","timestamp":1717041865000},"page":"65-68","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Serum CA 19-9 and CA 125 as a diagnostic marker in carcinoma of gallbladder"],"prefix":"10.4103","volume":"64","author":[{"given":"Manoj K.","family":"Bind","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi R.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatsala","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premala A.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240829","first-page":"2229","article-title":"Histological study of human gallbladder","volume":"4","author":"Chauhan","year":"2013","journal-title":"Int J Biomed Adv Res"},{"key":"R2-12-20240829","first-page":"631","article-title":"Unsuspected gallbladder cancer. A clinical retrospective study","volume":"16","author":"Hu","year":"2013","journal-title":"Arch Iran Med"},{"key":"R3-12-20240829","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.3748\/wjg.v20.i14.4085","article-title":"Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer","volume":"20","author":"Wang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"R4-12-20240829","first-page":"744","article-title":"Elevated serum level of carbohydrate antigen 19-9 in benign biliary stricture diseases can reduce its value as a tumor marker","volume":"7","author":"Lin","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"R5-12-20240829","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4236\/oji.2013.31005","article-title":"Significance of tumour markers in cancer of gall bladder","volume":"3","author":"Kankonkar","year":"2013","journal-title":"Open J Immunol"},{"key":"R6-12-20240829","first-page":"160","article-title":"Diagnostic value of serum CA242, CA 19-9, CA 15-3 and CA 125 in patients with carcinoma of the gallbladder","volume":"27","author":"Shukla","year":"2006","journal-title":"Trop Gastroenterol"},{"key":"R7-12-20240829","first-page":"667","article-title":"The clinical significance of elevated levels of serum CA 19-9","volume":"58","author":"Pavai","year":"2003","journal-title":"Med J Malaysia"},{"key":"R8-12-20240829","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/BF02946481","article-title":"Are elevated levels of the tumour marker CA19-9 of any clinical significance?--an evaluation","volume":"168","author":"McLaughlin","year":"1999","journal-title":"Ir J Med Sci"},{"key":"R9-12-20240829","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/BF01536670","article-title":"Elevated serum levels of tumor marker CA19-9 in acute cholangitis","volume":"33","author":"Albert","year":"1988","journal-title":"Dig Dis Sci"},{"key":"R10-12-20240829","first-page":"288","article-title":"Serum CA 19-9 levels in patients with hepatocellular carcinoma or cirrhosis","volume":"17","author":"Craxi","year":"1985","journal-title":"Ital J Gastroenterol"},{"key":"R11-12-20240829","first-page":"665","article-title":"CA 125 A potential tumor marker for gallbladder cancer","volume":"93","author":"Chaube","year":"2006","journal-title":"J SurgOncol"},{"key":"R12-12-20240829","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1093\/clinchem\/37.11.1968","article-title":"CA-125 concentrations in malignant and nonmalignant disease","volume":"37","author":"Daoud","year":"1991","journal-title":"Clin Chem"},{"key":"R13-12-20240829","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1128\/jcm.25.4.600-604.1987","article-title":"Detection of antibody to murine cytomegalovirus by enzyme-linked immunosorbent and indirect immunofluorescence assays","volume":"25","author":"Classen","year":"1987","journal-title":"J Clin Microbiol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_494_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:32:43Z","timestamp":1787067163000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_494_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_494_19","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}