{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:30:36Z","timestamp":1787070636306,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background:<\/jats:title>\n Non-thrombotic pulmonary embolism, an uncommon entity, is defined as the embolization of tissues, microorganisms, air, or foreign material. One subset in this non-thrombotic category is septic pulmonary embolism (SPE) that refers to embolism of microorganisms with or without a thrombotic mantle into the pulmonary vasculature. This condition is often recognized on the basis of imaging with a clinical correlation. Unfortunately, data regarding the pathological features are meager. This has prompted to review such cases at autopsy.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n To study the pathological features of SPE at autopsy.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Ten-year (2012 to 2021) autopsy records of the hospital were retrospectively reviewed. The diagnosis was based on the identification of acute necrotizing pulmonary arteritis with peri-bronchoarterial consolidation. These cases were analyzed with reference to the demographics, clinical characteristics, and pulmonary\/extrapulmonary findings at autopsy.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n Nil.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n According to the inclusion criterion, 19 cases demonstrated the presence of SPE. There were 11 men and 8 women with a mean age of 32.1 years. The major source of infection included infection arising from skin and musculo-skeletal system (11 patients, 59.7%). The common clinical presentation included fever, dyspnea, chest pain, hemoptysis, and altered sensorium. The cause of death was mainly due to septicemia and\/or confluent lung consolidations. A large number of bacterial colonies were seen in all;\n Candida<\/jats:italic>\n species were also identified in two cases. Other lung findings included diffuse alveolar damage, fresh arterial thrombosis, infarction, arterial pseudo-aneurysms, abscess formation, and pyogenic pleuritis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Presence of an extrapulmonary infection with persistent fever, bacteremia, and pulmonary complaints should raise suspicion for this entity, particularly in resource-poor settings, to prevent grave pulmonary complications.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_528_22","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T02:40:09Z","timestamp":1717036809000},"page":"740-743","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Septic pulmonary embolism: Is it an underestimated diagnosis?"],"prefix":"10.4103","volume":"66","author":[{"given":"Swati","family":"Kolhe","sequence":"first","affiliation":[{"name":"Department of Pathology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Vaideeswar","sequence":"additional","affiliation":[{"name":"Department of Pathology (Cardiovascular and Thoracic Division), Seth GS Medical College Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1183\/09031936.00141708","article-title":"Non-thrombotic pulmonary embolism","volume":"34","author":"Jorens","year":"2009","journal-title":"Eur Respir J"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rmed.2013.10.012","article-title":"Clinical characteristics of septic pulmonary embolism in adults: A systematic review","volume":"108","author":"Ye","year":"2014","journal-title":"Respir Med"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"e3846","DOI":"10.1097\/MD.0000000000003846","article-title":"Cardiac septic pulmonary embolism: A retrospective analysis of 20 cases in a Chinese population","volume":"95","author":"Song","year":"2016","journal-title":"Medicine"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1378\/chest.128.1.162","article-title":"Septic pulmonary embolism: Presenting features and clinical course of 14 patients","volume":"128","author":"Cook","year":"2005","journal-title":"Chest"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00428-015-1833-5","article-title":"The medical autopsy as quality assurance tool in clinical medicine: Dreams and realities","volume":"468","author":"van den Tweel","year":"2016","journal-title":"Virchows Arch"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0022-5223(19)41311-1","article-title":"Clinical spectrum of septic pulmonary embolism and infarction","volume":"75","author":"MacMillan","year":"1978","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/1874306401408010028","article-title":"Associations and outcomes of septic pulmonary embolism","volume":"8","author":"Goswami","year":"2014","journal-title":"Open Respir Med J"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"562","DOI":"10.6061\/clinics\/2016(10)02","article-title":"Septic pulmonary embolism requiring critical care: Clinicoradiological spectrum, causative pathogens and outcomes","volume":"71","author":"Chou","year":"2016","journal-title":"Clinics"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1186\/s12879-019-4672-1","article-title":"Septic pulmonary embolism in China: Clinical features and analysis of prognostic factors for mortality in 98 cases","volume":"19","author":"Jiang","year":"2019","journal-title":"BMC Infect Dis"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2214\/AJR.05.0681","article-title":"High-resolution MDCT of pulmonary septic embolism: Evaluation of the feeding vessel sign","volume":"187","author":"Dodd","year":"2006","journal-title":"Am J Roentgenol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_528_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:33:42Z","timestamp":1787067222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_528_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_528_22","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]},"assertion":[{"value":"2022-06-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}