{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:24:44Z","timestamp":1787757884363,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Renal tumors constitute approximately 3% of all malignancies in adults. They form a heterogenous group with variable morphological, immunohistochemical, and molecular features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The objective of this study was to analyze the spectrum of adult renal tumors at a tertiary care center and study the demographic and histomorphological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In this study, 55\/87 nephrectomy specimens resected for adult renal tumors during a 1-year period were analyzed retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were 4 benign (7.2%) and 51 (92.7%) malignant tumors. There was a male preponderance with a male: female ratio of 3.42:1. The tumors were seen to occur equally in both kidneys. The most common tumor was clear cell renal cell carcinoma (RCC), the conventional type accounting for 65.5% of our study group. There were one each of multilocular cystic renal neoplasm of low malignant potential, papillary RCC, chromophobe RCC, Mit family RCC, oncocytoma and angiomyolipoma and two clear cell papillary RCC during this 1-year period. Uncommon tumors included neuroendocrine carcinoma (1), epithelioid angiomyolipoma (1), mixed epithelial stromal tumor (1), Ewings sarcoma (2), and glomangioma (1). Five cases of urothelial carcinoma of renal pelvis\/ureter also were present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This article gives an overview of the spectrum of adult renal tumors at a tertiary care center with an in-depth literature review providing recent advances in each category of tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_53_21","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T06:15:36Z","timestamp":1654150536000},"page":"307-313","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Histopathological spectrum of adult renal tumours"],"prefix":"10.4103","volume":"66","author":[{"given":"Varghese S.","family":"Sheenu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu S.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadevan","family":"Pushpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel M.","family":"Ami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Rashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew L.","family":"Iona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Elizabeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20240829","first-page":"e1013","article-title":"Incidence, mortality and risk factors of kidney cancer in the world","volume":"5","author":"Mahdavifar","year":"2018","journal-title":"World Cancer Res J"},{"key":"R4-13-20240829","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/cancers12010085","article-title":"Molecular genetics of renal cell tumours: A Practical diagnostic approach","volume":"12","author":"Alaghehbandan","year":"2019","journal-title":"Cancers (Basel"},{"key":"R5-13-20240829","first-page":"2","article-title":"Extensively cystic renal neoplasms: Cystc nephroma, Cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma and cystic hamartoma of renal pelvis","volume":"15","author":"Eble","year":"1998","journal-title":"Semin Diagn Pathol"},{"key":"R6-13-20240829","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02890129","article-title":"Human chromophobe cell renal carcinoma","volume":"48","author":"Thoenes","year":"1985","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"R7-13-20240829","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/his.13735","article-title":"Grading of renal cell carcinoma","volume":"74","author":"Delahunt","year":"2019","journal-title":"Histopathlogy"},{"key":"R8-13-20240829","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00428-018-2389-y","article-title":"Cytogenetic and immunohistochemical study of 42 pigmented microcystic chromophobe renal cell carcinoma","volume":"473","author":"Guti\u00e9rrez","year":"2018","journal-title":"Virchows Arch"},{"key":"R9-13-20240829","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00428-016-2022-x","article-title":"Morphological, immunohistochemical, and chromosomal analysis of multicystic chromophobe renal cell carcinoma, an architecturally unusual challenging variant","volume":"469","author":"Foix","year":"2016","journal-title":"Virchows Arch"},{"key":"R10-13-20240829","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.anndiagpath.2015.05.001","article-title":"Chromophobe renal cell carcinoma with neuroendocrine and neuroendocrine-like features. Morphologic, immunohistochemical, ultrastructural, and array comparative genomic hybridization analysis of 18 cases and review of the literature","volume":"19","author":"Peckova","year":"2015","journal-title":"Ann Diagn Pathol"},{"key":"R11-13-20240829","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s42047-019-0035-x","article-title":"Emerging entities of renal cell neoplasia","volume":"2","author":"Delahunt","year":"2019","journal-title":"Surg Exp Pathol"},{"key":"R12-13-20240829","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1755-8794-3-59","article-title":"Birt-Hogg-Dub\u00e9 renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression","volume":"3","author":"Klomp","year":"2010","journal-title":"BMC Med Genomics"},{"key":"R13-13-20240829","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/his.13865","article-title":"Low-grade oncocytic tumour of kidney (CD117-negative, cytokeratin 7-positive): A distinct entity?","volume":"75","author":"Trpkov","year":"2019","journal-title":"Histopathology"},{"key":"R14-13-20240829","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2478\/raon-2013-0077","article-title":"Xp 11.2 translocation renal carcinoma in young adults; recently classified distinct subtype","volume":"48","author":"Kmetec","year":"2014","journal-title":"Radiol Oncol"},{"key":"R15-13-20240829","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/PAS.0b013e31824dd972","article-title":"TFE3 rearrangements in adult renal cell carcinoma: Clinical and pathologic features with outcome in a large series of consecutively treated patients","volume":"36","author":"Sukov","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"R16-13-20240829","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/modpathol.2013.208","article-title":"Clinical heterogeneity of Xp11 translocation renal cell carcinoma: Impact of fusion subtype, age, and stage","volume":"27","author":"Ellis","year":"2014","journal-title":"Mod Pathol"},{"key":"R17-13-20240829","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/cancers9090111","article-title":"Translocation renal cell carcinoma: An update on clinicopathological and molecular features","volume":"9","author":"Inamura","year":"2017","journal-title":"Cancers (Basel"},{"key":"R18-13-20240829","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s00595-003-2644-x","article-title":"Carcinoid tumor of the kidney presenting as a large abdominal mass: Report of a case","volume":"34","author":"Kawajiri","year":"2004","journal-title":"Surg Today"},{"key":"R19-13-20240829","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4103\/0970-1591.52905","article-title":"Renal neuroendocrine tumors","volume":"25","author":"Lane","year":"2009","journal-title":"Indian J Urol"},{"key":"R20-13-20240829","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1464-410X.2007.07116.x","article-title":"Renal neuroendocrine tumours: A clinicopathological study","volume":"100","author":"Lane","year":"2007","journal-title":"BJU Int"},{"key":"R21-13-20240829","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.critrevonc.2013.02.003","article-title":"Primary renal carcinoid: Treatment and prognosis","volume":"87","author":"Korkmaz","year":"2013","journal-title":"Crit Rev Oncol Hematol"},{"key":"R22-13-20240829","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00261-014-0129-6","article-title":"Prevalence of sporadic renal angiomyolipoma: A retrospective analysis of 61,389 in- and out-patients","volume":"39","author":"Fittschen","year":"2014","journal-title":"Abdom Imaging"},{"key":"R23-13-20240829","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.juro.2015.07.126","article-title":"Update on the diagnosis and management of renal angiomyolipoma","volume":"195","author":"Flum","year":"2017","journal-title":"J Urol"},{"key":"R24-13-20240829","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.juro.2008.05.041","article-title":"Clinical correlates of renal angiomyolipoma subtypes in 209 patients: Classic, fat poor, tuberous sclerosis associated and epithelioid","volume":"180","author":"Lane","year":"2008","journal-title":"J Urol"},{"key":"R25-13-20240829","first-page":"607","article-title":"Renal angiomyolipoma with lymph node involvement: A case report and literature review","volume":"26","author":"Lin","year":"2003","journal-title":"Chang Gung Med J"},{"key":"R26-13-20240829","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.radcr.2020.01.005","article-title":"A large bi-lobed classic renal angiomyolipoma with vena caval extension","volume":"15","author":"Abou Heidar","year":"2020","journal-title":"Radiol Case Rep"},{"key":"R27-13-20240829","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1097\/PAS.0b013e3181f17ac0","article-title":"A distinctive subset of PEComas harbors TFE3 gene fusions","volume":"34","author":"Argani","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"R28-13-20240829","first-page":"31","article-title":"Malignant mixed epithelial and stromal tumour of the kidney: A case report and a literature review","volume":"25","author":"Bakavi\u010dius","year":"2018","journal-title":"Acta Med Litu"},{"key":"R29-13-20240829","first-page":"7423642","article-title":"Glomangioma of the kidney: A rare case of glomus tumor and review of the literature","volume":"2017","author":"Almaghrabi","year":"2017","journal-title":"Case Rep Pathol"},{"key":"R30-13-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000478-200101000-00001","article-title":"Atypical and malignant glomus tumors: Analysis of 52 cases, with a proposal for the reclassification of glomus tumors","volume":"25","author":"Folpe","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"R31-13-20240829","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/IJPM.IJPM_699_18","article-title":"Primary Ewing sarcoma of the kidney in an adult and a child: Solving a diagnostic challenge","volume":"63","author":"Das","year":"2020","journal-title":"Indian J Pathol Microbiol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_53_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:57:23Z","timestamp":1787756243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_53_21"}},"subtitle":["A single center experience and review of literature"],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_53_21","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]}}}