{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:54:20Z","timestamp":1787828060557,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Psoriasis is a chronic inflammatory disease affecting the skin and multiple organ systems, and is associated with significant comorbidities such as cardiovascular disease, metabolic syndrome, and depression with no known cure. Angiogenesis is thought to play a key role in its pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      To demonstrate the expression of vascular endothelial growth factor (\n                      <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                      ) and\n                      <jats:italic toggle=\"yes\">CD31<\/jats:italic>\n                      in psoriasis compared to psoriasiform lesions, and to evaluate the role of angiogenesis in psoriasis. Materials and Methods: A total of 52 skin biopsies (39 psoriasis and 13 psoriasiform lesions) were analysed using Hematoxylin and Eosin (H and E) staining and immunohistochemistry for\n                      <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">CD31<\/jats:italic>\n                      expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Strong\n                      <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                      expression (&gt;50%) was observed in 43.6% of psoriasis cases, whereas 61.5% of psoriasiform lesions showed weak expression (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.018). The mean microvessel density (\n                      <jats:italic toggle=\"yes\">CD31<\/jats:italic>\n                      expression) was significantly higher in psoriasis (10.08 \u00b1 4.47) compared to psoriasiform lesions (7.87 \u00b1 2.29;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.026). A positive correlation was found between\n                      <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                      expression and\n                      <jats:italic toggle=\"yes\">CD31<\/jats:italic>\n                      (Pearson\u2019s\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.295).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      These findings highlights the role of angiogenesis in psoriasis, marked by the increased expression of\n                      <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                      in suprabasal keratinocytes and\n                      <jats:italic toggle=\"yes\">CD31<\/jats:italic>\n                      in superficial dermal vessels, thus underpinning the use of anti-angiogenic therapy for disease management in psoriasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_566_25","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:25Z","timestamp":1777374445000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The role of angiogenesis in psoriasis: An analysis of vascular endothelial growth factor (VEGF) and CD31 expression"],"prefix":"10.4103","volume":"69","author":[{"given":"Fathima","family":"Shabnam","sequence":"first","affiliation":[{"name":"Department of Pathology, MS Ramaiah Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangala","family":"Gowri","sequence":"additional","affiliation":[{"name":"Department of Pathology, MS Ramaiah Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda 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