{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:47:35Z","timestamp":1787071655191,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Littoral cell angioma (LCA) is a rare primary vascular neoplasm of the spleen that originates from the endothelial littoral cell lining of the red pulp sinuses. LCA has mostly benign behavior with a few reported cases of malignancy. LCA is strongly associated with diverse immunologic and neoplastic disorders. We report a case of LCA with synchronous renal cell carcinoma, adrenal cortical adenoma and JAK2 EXON 14 mutation positive Polycythemia vera. Histologically, entire spleen showed a neoplasm with anastomosing vascular channels lined by plump round cells. Diagnosis was confirmed by the endothelial\/histiocytic phenotype of tumor. To the best of our knowledge, this case is the first description of LCA associated with renal cell carcinoma, adrenal cortical adenoma and MPN.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_603_24","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T05:00:10Z","timestamp":1749445210000},"page":"858-861","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous occurrence of littoral cell angioma and multiple primary malignancies \u2013 A rare case report"],"prefix":"10.4103","volume":"68","author":[{"given":"Jaseela","family":"Teeka","sequence":"first","affiliation":[{"name":"Department of Pathology, Aster MIMS, Calicut, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Pathology, Aster MIMS, Calicut, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Kuruvilla","sequence":"additional","affiliation":[{"name":"Department of Pathology, Aster MIMS, Calicut, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthika Kundil","family":"Veetil","sequence":"additional","affiliation":[{"name":"Department of Pathology, Aster MIMS, Calicut, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"R1-20251208","doi-asserted-by":"crossref","first-page":"194","DOI":"10.20892\/j.issn.2095-3941.2016.0094","article-title":"Littoral-cell angioma of the spleen: A case report","volume":"14","author":"Liu","year":"2017","journal-title":"Cancer Biol Med J"},{"key":"R2-20251208","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00292-010-1281-6","article-title":"Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma","volume":"31","author":"Hansen","year":"2010","journal-title":"Pathologe J"},{"key":"R4-20251208","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/00000478-199111000-00001","article-title":"Littoral cell angioma: A novel splenic vascular lesion demonstrating histiocytic differentiation","volume":"15","author":"Falk","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"R5-20251208","doi-asserted-by":"crossref","first-page":"e37550","DOI":"10.1097\/MD.0000000000037550","article-title":"Littoral cell angioma of the spleen: A study of 10 cases case series and literature review","volume":"103","author":"Shen","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"R6-20251208","first-page":"239","article-title":"Littoral cell angioma of spleen: A clinicopathologic study of 17 cases","volume":"36","author":"Bi","year":"2007","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"R7-20251208","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/030089169808400516","article-title":"Littoral cell angioma of the spleen: An additional report of four cases with emphasis on the association with visceral organ cancers","volume":"84","author":"Bisceglia","year":"1998","journal-title":"Tumori"},{"key":"R8-20251208","doi-asserted-by":"crossref","first-page":"790332","DOI":"10.3389\/fonc.2022.790332","article-title":"Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis","volume":"12","author":"Wang","year":"2022","journal-title":"Front Oncol"},{"key":"R9-20251208","first-page":"6610","article-title":"Case Report Littoral cell angioma associated with extramedullary hematopoiesis and renal cell carcinoma: Case report and review","volume":"9","author":"Moore","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"key":"R10-20251208","doi-asserted-by":"crossref","first-page":"986","DOI":"10.29271\/jcpsp.2021.08.986","article-title":"Littoral cell angioma of the spleen presenting with thrombocytosis and splenic infarct","volume":"31","author":"Ozer","year":"2021","journal-title":"J Coll Physicians Surg Pak"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_603_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:50:28Z","timestamp":1787068228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_603_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_603_24","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"2024-07-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}